Changes in neuronal transmission in the rat hippocampus during behavior

Buzsáki, G; Grastyán, E; Czopf, J; Kellényi, L; Prohaska, O.

doi:10.1016/0006-8993(81)90833-7

Cited by 126 publications

(38 citation statements)

References 39 publications

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“…Micromachined silicon-based electrodes can eliminate or reduce some of the technical limitations inherent in multiple wire electrodes (Buzsáki et al 1981;Drake et al 1988;Kuperstein and Eichenbaum 1985;Petsche et al 1984). In silicon devices, the thin-film recording sites are defined lithographically.…”

Section: Introductionmentioning

confidence: 99%

Massively Parallel Recording of Unit and Local Field Potentials With Silicon-Based Electrodes

Csicsvari

Henze

Jamieson

et al. 2003

Journal of Neurophysiology

368

288

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Parallel recording of neuronal activity in the behaving animal is a prerequisite for our understanding of neuronal representation and storage of information. Here we describe the development of micro-machined silicon microelectrode arrays for unit and local field recordings. The two-dimensional probes with 96 or 64 recording sites provided high-density recording of unit and field activity with minimal tissue displacement or damage. The on-chip active circuit eliminated movement and other artifacts and greatly reduced the weight of the headgear. The precise geometry of the recording tips allowed for the estimation of the spatial location of the recorded neurons and for high-resolution estimation of extracellular current source density. Action potentials could be simultaneously recorded from the soma and dendrites of the same neurons. Silicon technology is a promising approach for high-density, high-resolution sampling of neuronal activity in both basic research and prosthetic devices.

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Section: Introductionmentioning

confidence: 99%

Massively Parallel Recording of Unit and Local Field Potentials With Silicon-Based Electrodes

Csicsvari

Henze

Jamieson

et al. 2003

Journal of Neurophysiology

368

288

View full text Add to dashboard Cite

show abstract

“…Information flow through the "trisynaptic circuit" of the hippocampal formation is dynamic and can vary depending on the animal's behavioral state (Winson and Abzug, 1978a,b;Buzsaki et al, 1981). Similarly, studies of the effect of distinct behavioral states on the induction of long-term potentiation (LTP), a phenomenon thought to reflect a cellular mechanism involved in learning (Bliss and Gardner-Medwin, 1973;Bliss and Lomo, 1973;Bliss and Collingridge, 1993), suggest that behavioral states such as alert waking states and rapid eye movement sleep are more conducive to the induction of LTP than other states (JonesLeonard et al, 1987;Bramham and Srebro, 1989).…”

Section: Introductionmentioning

confidence: 99%

Novel Environments Enhance the Induction and Maintenance of Long-Term Potentiation in the Dentate Gyrus

Davis¹,

Jones²,

Derrick³

2004

J. Neurosci.

108

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The induction of long-term potentiation (LTP) in the hippocampal formation can be modulated by different behavioral states. However, few studies have addressed modulation of LTP during behavioral states in which the animal is likely acquiring new information. Here, we demonstrate that both the induction and the longevity of LTP in the dentate gyrus are enhanced when LTP is induced during the initial exploration of a novel environment. These effects are independent from locomotor activity, changes in brain temperature, and theta rhythm. Previous exposure to the novel environment attenuated this enhancement, suggesting that the effects of novelty habituate with familiarity. LTP longevity also was enhanced when induced in familiar environments containing novel objects. Together, these data indicate that both LTP induction and maintenance are enhanced when LTP is induced while rats investigate novel stimuli. We suggest that novelty initiates a transition of the hippocampal formation to a mode that is particularly conducive to synaptic plasticity, a process that could allow for new learning while preserving the stability of previously stored information. In addition, LTP induced in novel environments elicited a sustained late LTP. This suggests that a single synaptic population can display distinct profiles of LTP maintenance and that this depends on the animal's behavioral state during its induction. Furthermore, the duration of LTP enhanced by novelty parallels the time period during which the hippocampal formation is thought necessary for memory, consistent with the view that dentate LTP is of a duration sufficient to sustain memory in the hippocampal formation.

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“…Buzsaki et al (13) showed that the effectiveness of input to the hippocampus is modulated by the concurrent theta activity controlled from the medial septum, which is itself affected by the ongoing behaviour of the rat. It was shown by Kitchigina et al (14) that when a rat encounters a novel object in the holeboard test, the noradrenergic input modulates the evoked activity of dentate granule cells.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Tetanus Toxin‐Induced Limbic Epilepsy on the Exploratory Response to Novelty in the Rat

et al. 1999

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Summary: Purpose: To investigate the exploratory response to novelty in rats that have recovered from experimental limbic epilepsy.Methods: Epilepsy was induced in 12 male rats by injecting a minute amount of tetanus toxin into the ventral hippocampus (and buffer vehicle was injected into 12 controls). Eight weeks after the injection, when the animals appeared behaviourally normal (and previous work would indicate that their electroencephalograms also would have returned to normal), they were tested on the playground maze. In this, their exploratory response to a novel object introduced in the context of seven familiar objects is measured. Simultaneously, their locomotion and investigation of familiar objects is measured.Results: Whereas the control animals showed a significant response to the novel object on both test days, in the toxininjected rats the novelty response was not present. There was no difference between the groups on the locomotion measure, hut the toxin rats explored the familiar as well as the novel objects less.Conclusions: The exploratory response to a novel object was abolished in the previously epileptic rats.

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Changes in neuronal transmission in the rat hippocampus during behavior

Cited by 126 publications

References 39 publications

Massively Parallel Recording of Unit and Local Field Potentials With Silicon-Based Electrodes

Massively Parallel Recording of Unit and Local Field Potentials With Silicon-Based Electrodes

Novel Environments Enhance the Induction and Maintenance of Long-Term Potentiation in the Dentate Gyrus

The Effect of Tetanus Toxin‐Induced Limbic Epilepsy on the Exploratory Response to Novelty in the Rat

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