Changes in Nutrition Impact Symptoms, Nutritional and Functional Status during Head and Neck Cancer Treatment

Neoh, May Kay; Zaid, Zalina Abu; Daud, Zulfitri Azuan Mat; Yusop, Nor Baizura Md; Ibrahim, Zuriati; Rahman, Zuwariah Abdul; Jamhuri, Norshariza

doi:10.3390/nu12051225

Cited by 41 publications

(52 citation statements)

References 30 publications

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“…The early stage of malnutrition, cancer cachexia, and sarcopenia are well-established risk factors for a scope of chemotherapy-induced toxicities, including individual symptoms such as fatigue, dysgeusia, mucositis, nausea/vomiting, hematologic toxicity, pain or composite clusters of these symptoms [ 33 ]. Patients with different cancers may be similarly affected, as indicate studies that included subjects with upper and lower gastrointestinal malignancies [ 23 , 34 ], breast cancers [ 35 ], lung tumors [ 36 ], or head and neck neoplasms [ 37 , 38 ]. Moreover, cancer malnutrition may be a significant risk factor for treatment-induced toxicities in more frail population, such as older patients, regardless their type of disease [ 39 ].…”

Section: Nutritional Care During Active Chemotherapy: Any New Tricks For This Old Issue?mentioning

confidence: 99%

The Clinical Value of Nutritional Care before and during Active Cancer Treatment

Aprile¹,

Basile²,

Giaretta³

et al. 2021

Nutrients

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Malnutrition and muscle wasting are frequently reported in cancer patients, either linked to the tumor itself or caused by oncologic therapies. Understanding the value of nutritional care during cancer treatment remains crucial. In fact, cancer-associated sarcopenia plays a key role in determining higher rates of morbidity, mortality, treatment-induced toxicities, prolonged hospitalizations and reduced adherence to anticancer treatment, worsening quality of life and survival. Planning baseline screening to intercept nutritional troubles earlier, organizing timely reassessments, and providing adequate counselling and dietary support, healthcare professional may positively interfere with this process and improve patients’ overall outcomes during the whole disease course. Several screening tools have been proposed for this purpose. Nutritional Risk Screening (NRS), Mini Nutritional Assessment (MNA), Patient Generated Subjective Global Assessment (PG-SGA) are the most common studied. Interestingly, second-level tools including skeletal muscle index (SMI) and bioelectric impedance analysis (BIA) provide a more precise assessment of body composition, even if they are more complex. However, nutritional assessment is not currently used in clinical practice and procedures must be standardized in order to improve the efficacy of standard chemotherapy, targeted agents or even checkpoint inhibitors that is potentially linked with the patients’ nutritional status. In the present review, we will discuss about malnutrition and the importance of an early nutritional assessment during chemotherapy and treatment with novel checkpoint inhibitors, in order to prevent treatment-induced toxicities and to improve survival outcomes.

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Section: Nutritional Care During Active Chemotherapy: Any New Tricks For This Old Issue?mentioning

confidence: 99%

The Clinical Value of Nutritional Care before and during Active Cancer Treatment

Aprile¹,

Basile²,

Giaretta³

et al. 2021

Nutrients

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“…The impact on patients’ dentition not only affects patients aesthetically but also the main function of chewing. The inability to chew properly could lead patients to suffer malnutrition and having to be selective of their food choices [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Can post-treatment oral cancer patients’ concerns reflect their cancer characteristics, HRQoL, psychological distress level and satisfaction with consultation?

Aminnudin¹,

Doss²,

Ismail³

et al. 2020

ecancer

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Background: Oral cancer and its treatment impact patients' post-treatment outcomes, challenging clinicians to manage them optimally. Addressing patients' concerns is central to holistic patient-centred care. Objectives: This study aimed to determine post-treatment oral cancer patients' concerns and its relationship with patients' clinical characteristics, health-related quality of life (HRQoL), psychological distress and patient satisfaction with the follow-up consultation. Methods: A total of 85 oral cancer patients were recruited from a three-armed pragmatic RCT study on the patient concerns inventory for head and neck cancer (PCI-H&N), which was conducted at six hospital-based oral maxillofacial specialist clinics throughout Malaysia. Malaysians aged 18 years and above and on follow-ups from 1 month to 5 years or more were eligible. Patients completed the PCI-H&N, functional assessment of cancer therapy-H&N v4.0 and Distress Thermometer at pre-consultation and satisfaction questionnaire at post-consultation. The data were analysed descriptively; multiple linear regression and multivariate logistic regression analyses were used to determine possible predictors of patients' HRQoL and psychological distress. Results: 'Recurrence or fear of cancer coming back' (31.8%) was most frequently selected. 43.5% of patients selected >4 concerns. A significantly high number of concerns were associated with patients of '1-month to 1-year post-treatment' (n = 84%; p = 0.001). A significant association existed between 'time after treatment completed' and patients' concerns of 'chewing/eating', 'mouth opening', 'swelling', 'weight', 'ability to perform', 'cancer treatment' and 'supplement/diet-related'. 'Chewing/eating' was predicted for low Research

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“…The effect of radiotherapy on nutrition may depend on the location of the tumor, the type of radiation used, the size of the exposure eld, the patient's status, and the duration of the dose. Radiotherapy of the head and neck can cause in ammation, reduced salivary secretion, dental caries, stomatitis, and di culty swallowing [25,26].…”

Section: Discussionmentioning

confidence: 99%

Validation of the Efficacy of the NUTRISCORE for Nutritional Screening of Cancer Patients in China

Kang

Shi

et al. 2021

Preprint

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Background: Malnutrition is common in cancer patients. The NUTRISCORE was a newly developed cancer-specific nutritional screening tool and validated by reference to the Patient-Generated Subjective Global Assessment (PG-SGA) and Malnutrition Screening Tool (MST) in Spain. We aimed to evaluate the performance of NUTRISCORE, MST, and PG-SGA in estimating the risk of malnutrition in Chinese cancer patients.Methods: Data from an open parallel and multicenter cross-section study in 29 clinical teaching hospitals in 14 Chinese cities were used. Cancer patients were assessed for malnutrition using PG-SGA, NUTRISCORE, and MST. The sensitivity, specificity, and areas under the receiver operating characteristic curve were estimated for NUTRISCORE and MST using PG-SGA as a reference.Results: A total of 1000 cancer patients were included. The mean age was 55.9 (19 to 92 years), and 47.5% were male. 450 patients (45.0%) had PG-SGA B and C, 29 patients (2.9%) had a NUTRISCORE ≥ 5, and 367 patients (36.7%) had MST ≥ 2. With PG-SGA as a reference method, the sensitivity, specificity, and area under the curve values of the NUTRISCORE was 6.2 %, 99.8%, and 0.53, respectively. The sensitivity, specificity, and area under the curve values of the MST were 50.9%, 74.9%, and 0.63, respectively. The kappa index between NUTRISCORE and the PG-SGA were 0.066 and 0.262 between MST and the PG-SGA (P < 0.05).Conclusions: NUTRISCORE was found a higher specificity and lower sensitivity compared with MST using PG-SGA as a reference method in cancer patients in China. Further studies are needed.

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Changes in Nutrition Impact Symptoms, Nutritional and Functional Status during Head and Neck Cancer Treatment

Cited by 41 publications

References 30 publications

The Clinical Value of Nutritional Care before and during Active Cancer Treatment

The Clinical Value of Nutritional Care before and during Active Cancer Treatment

Can post-treatment oral cancer patients’ concerns reflect their cancer characteristics, HRQoL, psychological distress level and satisfaction with consultation?

Validation of the Efficacy of the NUTRISCORE for Nutritional Screening of Cancer Patients in China

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