Changes in ocular surface status after phacoemulsification in patients with senile cataract

Kohli, Piyush; Arya, Shalini S.; Raj, Amit; Handa, Uma

doi:10.1007/s10792-018-0953-8

Cited by 46 publications

(75 citation statements)

References 35 publications

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“…Similar results were obtained in study by Kasetsuwan N et al 3 The study conducted by Kohli P et al also showed an increase in values postoperatively, similar to our study. 8 When compared to the previous studies in the literature, patients falling under dry eye criteria postoperatively were less in our study. This could be because of the difference in the size and site of incision.…”

Section: Discussioncontrasting

confidence: 54%

“…The phototoxic effect of the light of operating microscope causes production of reactive oxygen species, leading to devitalization of conjunctival cells and decrease in conjunctival goblet cell density. 8 Conventional topical therapy following cataract surgery includes topical corticosteroids (to manage inflammation) and antibiotics. 2 Topical corticosteroids commonly used postoperatively are dexamethasone and betamethasone in the form of drops and bed time ointment.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the Role of 1% Carboxymethylcellulose After Phacoemulsification Among North Indian Population : A Prospective, Randomized, Placebo Controlled Study

Sharma

et al. 2019

IJMBS

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Patients undergoing phacoemulsification with intraocular lens implantation present with dry eye symptoms postoperatively. The present study was done to evaluate the role of carboxymethylcellulose 1% added to conventional therapy to treat ocular discomfort and tear film instability in patients after cataract surgery. METHODS: A prospective, placebo controlled study of 150 patients with age-related cataract after undergoing phacoemulsification with intraocular lens implantation were postoperatively randomized to treatment with conventional therapy plus CMC 1% (study group, n = 75) or to conventional therapy plus 0.9% NaCl (control group, n = 75). Tear film breakup time (TBUT), schirmer test without anesthesia, lissamine green staining and ocular surface disease index (OSDI) scoring were done preoperatively (baseline) and postoperatively at 7 and 30 days. Results A significant increase in TBUT in the study group as compared to the control group on both day 7 and day 30 was seen (p<0.0001). The OSDI score on day 30 decreased in study group but increased in control group. Schirmer test showed an increase in both the groups on day 7. Day 30 recorded a significant increase in the study group and a decrease in the control group (p<0.0001). Conclusion The present study thus concludes that dry eye can develop immediately after phacoemulsification with a peak on day 7. However, use of 1% carboxymethylcellulose stabilizes the tear film and thus prevents development of dry eye.

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Section: Discussioncontrasting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Evaluation of the Role of 1% Carboxymethylcellulose After Phacoemulsification Among North Indian Population : A Prospective, Randomized, Placebo Controlled Study

Sharma

et al. 2019

IJMBS

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“…A recent report by DEWS recommends non-invasive diagnostic tests [19]. Nevertheless, TBUT, together with the OSDI scores and Schirmer I test, is still the most commonly used parameter to ascertain the presence of DED and monitor its changes over time [20,21]. Our study population undergoing cataract surgery had similar features to that of previous studies [20,21].…”

Section: Discussionmentioning

confidence: 60%

“…Nevertheless, TBUT, together with the OSDI scores and Schirmer I test, is still the most commonly used parameter to ascertain the presence of DED and monitor its changes over time [20,21]. Our study population undergoing cataract surgery had similar features to that of previous studies [20,21]. Of the whole study population, individuals with normal ocular surfaces (TBUT [ 7 s) and no relevant DED symptoms (OSDI B 12) were just 38% at baseline.…”

Section: Discussionmentioning

confidence: 85%

New Therapeutic Strategy and Innovative Lubricating Ophthalmic Solution in Minimizing Dry Eye Disease Associated with Cataract Surgery: A Randomized, Prospective Study

et al. 2020

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Introduction: To evaluate the effects of a new lubricating, antioxidant solution (VisuEvo Ò) on dry eye disease (DED) in patients undergoing cataract surgery. Methods: Patients requiring cataract surgery with either healthy ocular surface or mild DED (tear break-up time, TBUT [ 7, Schirmer I test [ 15 mm/5 min) were enrolled in this multicenter, open-label, randomized, prospective study. Scheduled visits were 2 weeks before surgery (screening), day of surgery (V0), week 1 (V1), and 2 (V2) after surgery. VisuEvo Ò was selfadministered three times daily for the whole study duration (group A); the control group (group B) had no tear substitute administration. The primary endpoint was the change in TBUT over time; the secondary endpoints were changes in Ocular Surface Disease Index (OSDI), ocular surface staining, the Schirmer I test, and osmometry. Results: A total of 45 patients were included (group A, 23; group B, 22; age 74 ± 8 years). At the screening, TBUT was similar between the groups (group A, 8.5 ± 1.8 s; group B, 7.8 ± 0.7, p = 0.11). At the scheduled visits, TBUT increase vs screening visit was significantly higher in group A: ?1.2 s at V0, ?1.4 s at V1, and ?1.9 s at V2 (p \ 0.01). Also, OSDI was significantly lower in group A at V0, V1, and V2 (p \ 0.027). After surgery, corneal staining was absent in 65-78% of group A compared with 54-59% in group B. The two groups did not show any significant differences of osmometry and the Schirmer I test. Conclusions: The ocular surface was more protected and quickly restored from surgery when VisuEvo Ò was used from 2 weeks preoperatively to 2 weeks postoperatively. Trial registration: ClinicalTrials.gov identifier, NCT03833908

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“…However, in a prospective study of 50 patients by Kohli et al. 15 and a retrospective study of 96 patients by Cetinkaya et al., 16 the signs and symptoms of DED appeared to return to pre-operative levels at 3 months.…”

Section: Prevalence Of Cataract Surgery Associated Dedmentioning

confidence: 92%

Cataract surgery and dry eye disease: A review

Naderi

Gormley

O’Brart

2020

European Journal of Ophthalmology

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Aim To review published literature concerning cataract surgery and dry eye disease (DED). Methods A search was undertaken using the following: PubMed (all years), Web of Science (all years), Ovid MEDLINE(R) (1946 to 12 December 2019), Ovid MEDLINE(R) Daily Update 10 December 2019, MEDLINE and MEDLINE non-indexed items, Embase (1974–2019, week 49), Ovid MEDLINE (R) and Epub Ahead of Print, In-Process and Other Non-Indexed Citations and Daily (1946 to 12 December 2019), CENTRAL (including Cochrane Eyes and Vision Trials Register; Cochrane Library: Issue 12 of 12 December 2019), metaRegister of Controlled Trials (mRCT) ( www.controlled-trials.com ), ClinicalTrials.gov ( www.clinicaltrial.gov ) and WHO International Clinical Trials Registry Platform ( www.who.int/ictrp/search/en ). Search terms included ‘cataract surgery’, ‘phacoemulsification’ and ‘cataract extraction’, combined with ‘dry eyes’ and ‘ocular surface’. Relevant in-article references not returned in our searches were also considered. Results Publications identified included systematic reviews, meta-analysis, randomized controlled trials, cohort studies, case series and laboratory-based studies. Published data highlighting the burden of DED both prior and following cataract surgery were reviewed as well as studies highlighting the effects of cataract surgery on the ocular surface, intra-operative measures to reduce deleterious effects on the ocular surface and current evidence on the management options of post-operative DED. Conclusions DED is common and can be exacerbated by cataract surgery. Ophthalmologists need to assess for pre-existing DED and instigate treatment before surgery; be aware of reduced accuracy of measurements for surgical planning in the presence of DED; limit intra-operative surgical factors damaging to the ocular surface; and consider management to reduce DED post-operatively.

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Changes in ocular surface status after phacoemulsification in patients with senile cataract

Cited by 46 publications

References 35 publications

Evaluation of the Role of 1% Carboxymethylcellulose After Phacoemulsification Among North Indian Population : A Prospective, Randomized, Placebo Controlled Study

Evaluation of the Role of 1% Carboxymethylcellulose After Phacoemulsification Among North Indian Population : A Prospective, Randomized, Placebo Controlled Study

New Therapeutic Strategy and Innovative Lubricating Ophthalmic Solution in Minimizing Dry Eye Disease Associated with Cataract Surgery: A Randomized, Prospective Study

Cataract surgery and dry eye disease: A review

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