Changes in Open Field Behavior, Spatial Memory, and Hippocampal Parvalbumin Immunoreactivity Following Enrichment in Rats Exposed to Neonatal Anoxia

Iuvone, Laura; Geloso, Maria Concetta; Dell'Anna, Elisabetta

doi:10.1006/exnr.1996.0077

Cited by 90 publications

(61 citation statements)

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“…Later on, Rosenzweig and colleagues (Rosenzweig, 1966) described EE as a combination of complex inanimate and social stimulation. Since then, many studies in laboratory settings have confirmed and extended the notion that rodents reared in EE show improved learning and memory performance (Iuvone et al, 1996;Young et al, 1999). In addition, exposure to an EE has been shown to induce biochemical and structural changes in several brain regions in particular in the cortex and the hippocampus (Diamond et al, 1976;Kempermann et al, 1997;Nithianantharajah and Hannan, 2006;van Praag et al, 2000).…”

Section: Introductionmentioning

confidence: 91%

Environmental enrichment during adolescence regulates gene expression in the striatum of mice

et al. 2008

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We have previously shown that environmental enrichment decreases the activating and rewarding effects of the psych psychostimulant cocaine and increases resistance to the neurotoxic effect of the Parkinson-inducing drug MPTP. These effects were accompanied by an increase in the striatal expression of the neurotrophin BDNF, an increase in the striatal levels of delta-Fos B and by a decrease in striatal levels of the dopamine transporter, the main molecular target for cocaine and MPTP. Here, we used cDNA arrays to investigate the effects of rearing mice in enriched environments from weaning to adulthood on the profile of expression of genes in the striatum focusing on genes involved in intracellular signalling and functioning. We found that mice reared in an enriched environment show several alterations in the levels of mRNA coding for proteins involved in cell proliferation, cell differentiation, signal transduction, transcription and translation, cell structure and meta metabolism. Several of these findings were further confirmed by real-time quantitative PCR and, in the case of protein kinase C lambda, also by western blot. These findings are the first description of alterations in striatal gene expression by an enriched environment. The striatal gene expression regulation by environment that we report here may play a role in the resistance to the effects of drugs of abuse and dopaminergic neurotoxins previously reported.

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Section: Introductionmentioning

confidence: 91%

Environmental enrichment during adolescence regulates gene expression in the striatum of mice

et al. 2008

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“…Since then, a number of studies have reported that rodents reared in enriched environments show improved performance in various spatial maze and avoidance tasks (2)(3)(4). Consistent with these behavioral tests, exposure to an enriched environment has been shown to induce biochemical and structural changes in the cortex and other brain regions, including the hippocampal dentate gyrus and CA1 region (5).…”

mentioning

confidence: 87%

Effects of environmental enrichment on gene expression in the brain

Rampon

Jiang

Dong

et al. 2000

Proc. Natl. Acad. Sci. U.S.A.

557

359

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“…Alterações nessa região decorrentes de estímulos anóxicos podem resultar em déficits motores, cognitivos e distúrbios neuro-comportamentais, com prejuízo na aprendizagem e memória espacial (DELL'ANNA et al, 1997;IUVONE et al, 1996), que persistem por toda a vida. (CAPUTA et al, 2005;BUWALDA et al, 1995).…”

Section: Formação Hipocampalunclassified

“…condições anóxicas é descrito como igual a 12,5% (TAKADA et al, 2011;IUVONE et al, 1996;DELL'ANNA et al, 1995;1991).…”

Section: Condições Experimentaisunclassified

“…O modelo experimental escolhido para provocar anóxia em neonatos, foi adaptado da literatura (ROGALSKA et al, 2006;TANG e NAKAZAWA, 2005;CAPUTA et al, 2005;LAVIOLA et al, 2004;DELL'ANNA et al, 1997;IUVONE et al, 1996;BUWALDA et al, 1995), e validado por nosso grupo de pesquisa (TAKADA et al, 2011). Entretanto, dentro de um mesmo grupo experimental a espessura foi constante.…”

Section: Condições Experimentaisunclassified

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Estudo da imunorreatividade da proteína S100b no Hipocampo e Núcleo do Trato Solitário de ratos neonatos submetido à anóxia.

Allemandi¹

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Changes in Open Field Behavior, Spatial Memory, and Hippocampal Parvalbumin Immunoreactivity Following Enrichment in Rats Exposed to Neonatal Anoxia

Cited by 90 publications

References 0 publications

Environmental enrichment during adolescence regulates gene expression in the striatum of mice

Environmental enrichment during adolescence regulates gene expression in the striatum of mice

Effects of environmental enrichment on gene expression in the brain

Estudo da imunorreatividade da proteína S100b no Hipocampo e Núcleo do Trato Solitário de ratos neonatos submetido à anóxia.

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