Changes in patterns of antibiotic use in Chinese public hospitals (2005–2012) and a benchmark comparison with Sweden in 2012

Sun, Jing; Shen, Xiao; Li, Meng; He, Lingjuan; Guo, Shuyan; Skoog, Gunilla; Grape, Malin; Cars, Otto; Dong, Shaoming

doi:10.1016/j.jgar.2015.03.001

Cited by 26 publications

(27 citation statements)

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“…As Xiao et al explain, implementation of these policies have included extensive use of targets, production of guidelines and formulary restrictions, improved education, and liability assignment to institutions and even individuals [15]. There have been clear successes in reducing inappropriate antibiotic use in the past few years, but as these policies have largely been focussed on hospital care in urban areas, it is less clear how much of an effect they have had on the situation in rural populations [17], [18]. These policies are linked to and embedded within China's huge and complex set of on-going healthcare reforms.…”

Section: The Context For a One Health Research Project In Chinamentioning

confidence: 99%

“…The Swedish Government and its agencies have made substantial funding available for research projects and other initiatives that address various aspects of antibiotic resistance. This funding has frequently aimed to stimulate and support international collaborations, recognising that antibiotic resistance is a global concern, and one that cannot be managed within a single country [10], [18], [22], [23], [24].…”

Section: Collaborations Between China and Swedenmentioning

confidence: 99%

“…Projects investigating antibiotic use and resistance in China were launched and reported, identifying high levels of ESBL bacteria in rural settings, gaps in knowledge about antibiotics in rural caregivers and rural doctors, and describing recent trends in antibiotic usage across several provinces [10], [18], [27]. The political support extended to the National Natural Science Foundation of China (NSFC) and the Swedish Research Council (SRC), who co-hosted a workshop on antibiotic resistance in Beijing in May 2013, and formed a joint funding call for research collaborations between the two countries [28].…”

Section: Collaborations Between China and Swedenmentioning

confidence: 99%

“…The governmental authorities on both sides participate as scientific partners. Some of the partners have previously collaborated on smaller-scale research projects [10], [18], [27].…”

Section: Impact – Purpose and Scopementioning

confidence: 99%

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Building bridges to operationalise one health – A Sino-Swedish collaboration to tackle antibiotic resistance

et al. 2016

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Antibiotic resistance is a complex global health challenge. The recent Global Action Plan on antimicrobial resistance highlights the importance of adopting One Health approaches that can cross traditional disciplinary boundaries. We report on the early experiences of a multisectoral Sino-Swedish research project that aims to address gaps in our current knowledge and seeks to improve the situation through system-wide interventions. Our research project is investigating antibiotic use and resistance in a rural area of China through a combination of epidemiological, health systems and laboratory investigations. We reflect here on the challenges inherent in conducting long distance cross-disciplinary collaborations, having now completed data and sample collection for a baseline situation analysis. In particular, we recognise the importance of investing in aspects such as effective communication, shared conceptual frameworks and leadership. We suggest that our experiences will be instructive to others planning to develop similar international One Health collaborations.

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Section: The Context For a One Health Research Project In Chinamentioning

confidence: 99%

Section: Collaborations Between China and Swedenmentioning

confidence: 99%

Section: Collaborations Between China and Swedenmentioning

confidence: 99%

“…The governmental authorities on both sides participate as scientific partners. Some of the partners have previously collaborated on smaller-scale research projects [10], [18], [27].…”

Section: Impact – Purpose and Scopementioning

confidence: 99%

See 2 more Smart Citations

Building bridges to operationalise one health – A Sino-Swedish collaboration to tackle antibiotic resistance

et al. 2016

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“…The Chinese Ministry of Health also launched the national antibiotic stewardship program, People's Republic of China antimicrobial resistance surveillance system, and other policies to control antibiotic resistance. 5,9,10 Based on this background, the First Affiliated Hospital of Zhejiang University (FAHZU), ranking one of the first-class hospitals in People's Republic of China, has implemented multifaceted interventions, including pharmacist-led antibiotic stewardship, surveillance and regular proclamation of antibiotic resistance data, financial penalties, and so on. Although the antibiotic consumption and resistance in People's Republic of China were characterized in previous studies, 4,[11][12][13][14][15][16] few studies focused on the correlation between these two elements during a relatively long period.…”

Section: Introductionmentioning

confidence: 99%

<p>Trends and correlation of antibiotic susceptibility and antibiotic consumption at a large teaching hospital in China (2007–2016): a surveillance study</p>

Wang

Yang

Zhang

et al. 2019

TCRM

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To evaluate the trends and correlation between the antibiotic consumption and susceptibility of eight most frequent isolates in the First Affiliated Hospital of Zhejiang University (2007-2016). Method: This study was based on the yearly surveillance data in a 2500-bed capacity tertiary-care teaching hospital. Trends and correlation were, respectively, analyzed by linear regression and Pearson's correlation coefficient. Results: The consumption of all antibiotics decreased by 10.8% over time, especially firstgeneration cephalosporins (p=0.001), fourth-generation cephalosporins (p=0.01), aminoglycosides (p<0.001), and fluoroquinolones (p<0.001), but increased remarkably in linezolid, carbapenems, glycopeptides, and third-generationcephalosporins (3GCs). 72.7% of trend analyses indicated increased susceptibility to antibiotics with remarkably decreased consumption. In particular, susceptibility to aminoglycosides and fluoroquinolones remarkably increased in seven of eight pathogens and negatively correlated with the corresponding antibiotic consumption (p<0.05). Isolation density significantly declined in methicillin-resistant Staphylococcus aureus (54.9-41.3%, p=0.009) and in extended-spectrum β-lactamase producing Klebsiella pneumoniae (42.4-15.6%, p=0.007), which positively correlated with the consumption of fluoroquinolones. The susceptibility to antibiotics with increased consumption was almost stable. Decreased trends were only found in K. pneumoniae to imipenem (81-71.3%, p=0.046) and cefoperazone/sulbactam (70.8-61.0%, p=0.014) and in Acinetobacter baumannii to cefoperazone/sulbactam (59-28%, p=0.007), which negatively correlated with the consumption of carbapenems (r=−0.649, p=0.042) and 3GCs/β-lactamase inhibitors (p<0.05), respectively. The consumption of glycopeptides even positively correlated with the growing susceptibility to vancomycin in Enterococcus faecium (r=0.633, p=0.049) and Enterococcus faecalis (r=0.752, p=0.012). Conclusion: The susceptibility to antibiotics with decreased consumption increased remarkably, but maintained stable to those with growing consumption. The stricter management of carbapenems and 3GCs is necessary.

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Ozonation efficiency in removing organic micro pollutants from wastewater with respect to hydraulic loading rates and different wastewaters

El-taliawy

Ekblad

Nilsson³

et al. 2017

Chemical Engineering Journal

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Changes in patterns of antibiotic use in Chinese public hospitals (2005–2012) and a benchmark comparison with Sweden in 2012

Cited by 26 publications

References 9 publications

Building bridges to operationalise one health – A Sino-Swedish collaboration to tackle antibiotic resistance

Building bridges to operationalise one health – A Sino-Swedish collaboration to tackle antibiotic resistance

<p>Trends and correlation of antibiotic susceptibility and antibiotic consumption at a large teaching hospital in China (2007–2016): a surveillance study</p>

Ozonation efficiency in removing organic micro pollutants from wastewater with respect to hydraulic loading rates and different wastewaters

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