Changes in peripheral lymphocyte subsets in patients after partial microwave ablation of the spleen for secondary splenomegaly and hypersplenism: A preliminary study

Duan, Yaqi; Gao, Yongyan; Ni, Xin; Wang, Y; Feng, Long; Liang, Ping

doi:10.1080/02656730701474533

Cited by 18 publications

(10 citation statements)

References 33 publications

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“…The most common anatomic sites for microwave ablation worldwide are the liver, lung, kidney, prostate and bone 85. Other areas of interest include the breast, thyroid, brain and spleen 86–89…”

Section: Applicationsmentioning

confidence: 99%

Microwave Tissue Ablation: Biophysics, Technology, and Applications

Brace

2010

Crit Rev Biomed Eng

278

214

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Microwave ablation is an emerging treatment option for many cancers, cardiac arrhythmias and other medical conditions. During treatment, microwaves are applied directly to tissues to produce rapid temperature elevations sufficient to produce immediate coagulative necrosis. The engineering design criteria for each application differ, with individual consideration for factors such as desired ablation zone size, treatment duration, and procedural invasiveness. Recent technological developments in applicator cooling, power control and system optimization for specific applications promise to increase the utilization of microwave ablation in the future. This article will review the basic biophysics of microwave tissue heating, provide an overview of the design and operation of current equipment, and outline areas for future research for microwave ablation.

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Section: Applicationsmentioning

confidence: 99%

Microwave Tissue Ablation: Biophysics, Technology, and Applications

Brace

2010

Crit Rev Biomed Eng

278

214

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“…One month after MWA, 10 patients with hypersplenism that had developed as a result of portal hypertension exhibited a transient peripheral increase of T helper cells (CD3 + CD4 + ) and B cells, but not of cytotoxic (CD3 + CD8 + ) T cells [22]. In a larger cohort of patients suffering from HCC, immune cell infiltration was studied by immunohistochemistry analyses of biopsy tumor samples taken either before or at different timepoints (3–30 days) after MWA application.…”

Section: Microwave Ablationmentioning

confidence: 99%

“…This method could therefore be effectively applied in tissues with higher impedance like lung and bone [12]. In humans, MWA is currently mainly applied for the treatment of HCC [21, 22]. …”

Section: Introductionmentioning

confidence: 99%

More Than Just Tumor Destruction: Immunomodulation by Thermal Ablation of Cancer

Haen

Pereira

Salih

et al. 2011

Clinical and Developmental Immunology

203

148

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Over the past decades, thermoablative techniques for the therapy of localized tumors have gained importance in the treatment of patients not eligible for surgical resection. Anecdotal reports have described spontaneous distant tumor regression after thermal ablation, indicating a possible involvement of the immune system, hence an induction of antitumor immunity after thermoinduced therapy. In recent years, a growing body of evidence for modulation of both adaptive and innate immunity, as well as for the induction of danger signals through thermoablation, has emerged. Induced immune responses, however, are mostly weak and not sufficient for the complete eradication of established tumors or durable prevention of disease progression, and combination therapies with immunomodulating drugs are being evaluated with promising results. This article aims to summarize published findings on immune modulation through radiofrequency ablation, cryoablation, microwave ablation therapy, high-intensity focused ultrasound, and laser-induced thermotherapy.

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“…US-guided tissue thermal ablation with microwave is an effective therapeutic technique which has been successfully adopted as a treatment modality of primary and metastatic tumours of the liver and kidney with acceptable low complication rates [11,16]. A clinical study has shown the feasibility and safety of MW ablation in the management of hypersplenism without sacrificing efficacy [17]. Theoretically, MW ablation for splenic tumours has some potential benefit compared to other ablation methods including RF ablation and cryoablation: (1) MW has a larger ablation zone of active heating and its transmission in tissue is not limited by desiccation and charring.…”

Section: Discussionmentioning

confidence: 99%

Ultrasound-guided percutaneous microwave ablation of splenic metastasis: Report of four cases and literature review

Yu¹,

Liang²,

Yu³

et al. 2011

International Journal of Hyperthermia

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Changes in peripheral lymphocyte subsets in patients after partial microwave ablation of the spleen for secondary splenomegaly and hypersplenism: A preliminary study

Abstract: Microwave ablation therapy for splenomegaly and hypersplenism appears to have a favourable effect on peripheral lymphocyte subsets. A relationship may exist between the ablation volume and the level of peripheral lymphocyte subsets.

Cited by 18 publications

References 33 publications

Microwave Tissue Ablation: Biophysics, Technology, and Applications

Microwave Tissue Ablation: Biophysics, Technology, and Applications

More Than Just Tumor Destruction: Immunomodulation by Thermal Ablation of Cancer

Ultrasound-guided percutaneous microwave ablation of splenic metastasis: Report of four cases and literature review

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