Changes in plasma concentrations of insulin-like peptide 3 and testosterone from birth to pubertal age in beef bulls

Kawate, Noritoshi; Ohnari, Aki; Pathirana, Indunil; Sakase, Mitsuhiro; Büllesbach, Erika E.; Takahashi, Masahiro; Inaba, Toshio; Tamada, Hiromichi

doi:10.1016/j.theriogenology.2011.07.011

Cited by 36 publications

(37 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We suggest that testosterone-enhanced growth in bulls vs. steer cohorts is not realized until bulls reach ages beyond the typical weaning age (d 214 in the current study). This hypothesis is supported by previous research (Kawate et al, 2011) evaluating plasma testosterone concentration in bulls of different pubertal phases in which prepubertal bulls (3 to 6 mo of age) had significantly less plasma testosterone compared to early-(6 to 12 mo of age), late-(12 to 18 mo of age), or post-(18 to 22 mo of age) pubertal bull cohorts. Further research is needed to elucidate whether BW differences exist for bull vs. steer cohorts at various ages.…”

Section: Preweaning Periodsupporting

confidence: 76%

Effect of castration timing and oral meloxicam administration on growth performance, inflammation, behavior, and carcass quality of beef calves12

Brown

Powell

Kegley

et al. 2015

Journal of Animal Science

View full text Add to dashboard Cite

Beef bull calves (n = 62) were assigned randomly, within sire breed, to 1 of 4 treatments at birth. Treatments were 1) surgical castration near birth, 2) surgical castration near birth with oral administration of meloxicam (1 mg/kg BW), 3) surgical castration at weaning (WNG), or 4) surgical castration at weaning with oral administration of meloxicam (1 mg/kg BW; WMX). A subset of calves (n = 7/treatment group) were selected randomly near birth for blood collection, behavioral analyses, and rectal temperature (RT) records for a 7-d postcastration period on d 0 (birth), 1, 3, and 7, and on d 214 (weaning), 214 + 6 h, 215, 217, 221, and 228. Calf standing and lying activity were monitored from the same subsets by recording x- and y-axis positions of an accelerometer attached to the right metatarsus for 7 d postcastration. Calf BW was recorded throughout the entire production cycle, and carcass data were collected at slaughter. For statistical analyses, bulls left intact at birth were considered a positive control (BUL) for observations that occurred before their treatment application at weaning; likewise, bulls castrated at birth were considered a negative control (STR) during postweaning observations. No difference (P > 0.88) occurred in ADG between treatments throughout the preweaning period (d 0 to 214); however, 56-d postweaning ADG was greatest ( P= 0.02) in STR, intermediate in WMX, and least in WNG. At weaning, haptoglobin (Hp) was greater (P ≤ 0.005) for WNG and WMX compared to STR on d 214+6 h, 215, and 217, and Hp was greater (P = 0.05) in WNG compared to WMX on d 217. Neutrophils increased (P < 0.001) and red blood cells decreased (P ≤ 0.03) for WNG and WMX on d 214+6 h and 217, respectively. Postweaning behavior observations indicated that STR calves spent the least proportion of time standing (P = 0.002) when compared to WNG and WMX. Furthermore, WMX calves exhibited a greater proportion of time spent standing (P = 0.03) compared to WNG. Grazing and finishing phase ADG and carcass measurements did not differ (P ≥ 0.24) across treatments. In this study, surgical castration at weaning, but not near birth, altered the acute phase response, behavior, and growth performance. Oral meloxicam reduced serum Hp and improved ADG briefly when administered to calves castrated at weaning. Oral administration of meloxicam may be efficacious for mitigating some of the stress and inflammation associated with castration of weaning-age bull calves.

show abstract

Section: Preweaning Periodsupporting

confidence: 76%

Effect of castration timing and oral meloxicam administration on growth performance, inflammation, behavior, and carcass quality of beef calves12

Brown

Powell

Kegley

et al. 2015

Journal of Animal Science

View full text Add to dashboard Cite

show abstract

“…A linear relation in plasma testosterone with age was observed among the animals aged between 192 and 708 days. Similar changes in plasma testosterone were also noticed in investigations conducted on Egyptian buffalo bulls (Hemeida et al, 1985), Angus bull calves (Moura et al, 2001), Angus and Angus × Charolais bull calves (Brito et al, 2007), and Japanese Black bull calves (Kawate et al, 2011).…”

Section: Resultssupporting

confidence: 82%

Age-related changes in testicular parameters and their relationship to thyroid hormones and testosterone in male Murrah buffaloes

2018

View full text Add to dashboard Cite

Abstract. The present study aims to investigate the age-related changes in testicular parameters and their association with plasma triiodothyronine (T 3 ), thyroxine (T 4 ), and testosterone in male Murrah buffaloes. Testicular measurements and single blood samples were collected from male Murrah buffaloes (n = 103) aged between 6 months and 8 years. The correlation coefficients of average testicular length (ATL), paired testis width (PTW), and scrotal circumference (SC) in relation to age were 0.88, 0.91, and 0.90, respectively. The regression equation between testicular weight (TW) and age was Y = 1.48 × x 0.005 (r = 0.90; R 2 = 0.79). Plasma T 4 and testosterone increased significantly (p < 0.001) with age and their levels ranged between 12.9 and 41.8 and 0.05 and 1.48 ng mL −1 , respectively. With respect to associations between testicular parameters and plasma hormone levels, we observed significant (p < 0.01) correlations between ATL, PTW, SC, TW, and plasma T 4 . A significant correlation (r = 0.31; p < 0.01) between plasma T 4 and testosterone levels was also observed. However, the correlations between plasma T 3 and testicular parameters and plasma T 3 and testosterone were non-significant. From the present study, we conclude that plasma T 4 is positively correlated with testicular parameters and plasma testosterone, indicating its role in testis development and steroidogenesis.

show abstract

“…Pulsatile GNRH leads to increased secretion of pulsatile LH from the anterior pituitary, specifically stimulating Leydig cells to differentiate from resident testicular stem cells and produce androgens as well as the peptide hormone INSL3. This is well documented for INSL3 at RNA and/or secreted peptide levels in rodents (Balvers et al 1998, Sadeghian et al 2005, ruminants (Kawate et al 2011), and humans , Wikströ m et al 2006, Johansen et al 2013. Because of their relatively more homogeneous genetic nature, rodents exhibit a consistent age-dependent increase in circulating INSL3 up to a maximum at the time of first appearance of sperm in the epididymis (ca.…”

Section: Insl3 In the Adult Malementioning

confidence: 85%

Insulin-like factor 3 as a monitor of endocrine disruption

Anand‐Ivell

Ivell

2014

Reproduction

View full text Add to dashboard Cite

Insulin-like factor 3 (INSL3) is generated and secreted by differentiated interstitial Leydig cells of the testes in both fetal and adult males of all mammalian species so far analyzed. All evidence to date suggests that it is produced constitutively, independently of acute regulation by the hypothalamo-pituitary-gonadal (HPG) axis, in amounts which reflect the numbers and differentiation status of the Leydig cells. This Leydig cell functional capacity is otherwise monitored only by androgen output, which, however, is massively confounded by acute regulation from the HPG axis and other factors leading to substantial and irregular short-term variation. Leydig cells are a primary target of endocrine-disrupting agents in the context of the testicular dysgenesis syndrome in the fetal male, as well as in the adult. In the male fetus, INSL3 is responsible for the first phase of testicular descent, and hence is directly linked to the etiology of cryptorchidism. In this study, by measuring INSL3 production, for example, during fetal life via amniotic fluid, or as secretions from fetal testis explants, or in adult peripheral blood, we and others have shown that INSL3 represents a useful quantitative and sensitive endpoint for assessing the impact of endocrine-disrupting agents and their mechanisms of action.Reproduction (2014) 147 R87-R95

show abstract

Changes in plasma concentrations of insulin-like peptide 3 and testosterone from birth to pubertal age in beef bulls

Cited by 36 publications

References 24 publications

Effect of castration timing and oral meloxicam administration on growth performance, inflammation, behavior, and carcass quality of beef calves12

Effect of castration timing and oral meloxicam administration on growth performance, inflammation, behavior, and carcass quality of beef calves12

Age-related changes in testicular parameters and their relationship to thyroid hormones and testosterone in male Murrah buffaloes

Insulin-like factor 3 as a monitor of endocrine disruption

Contact Info

Product

Resources

About