Changes in plasma ghrelin levels, gastric ghrelin production, and body weight after Helicobacter pylori cure

Osawa, Hiroyuki; Kita, Hiroto; Ohnishi, Hirohide; Nakazato, Masamitsu; Date, Yukari; Bowlus, Christopher L.; Ishino, Yumiko; Watanabe, Eiko; Shiiya, Tomomi; Ueno, Hiroaki; Hoshino, Hiroko; Satoh, Kiichi; Sugano, Kentaro

doi:10.1007/s00535-006-1880-4

Cited by 47 publications

(50 citation statements)

References 38 publications

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“…Together, these observations suggest that ghrelin levels respond in a compensatory fashion to bidirectional alterations in body weight, consistent with the hypothesis that ghrelin contributes to the known adaptive metabolic responses to such alterations (51). Yet, in agreement with our data, Osawa et al recently showed that mean plasma ghrelin concentrations significantly decreased after successful H. pylori treatment, though with wide variation (48). In that report, changes in plasma ghrelin concentrations before and 12 weeks after H. pylori cure were inversely correlated with body weight change but not with gastric ghrelin production.…”

Section: Discussionsupporting

confidence: 93%

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Long-term effects of Helicobacter pylori eradication on circulating ghrelin and leptin concentrations and body composition in prepubertal children

Pacifico¹,

Anania²,

Osborn³

et al. 2008

European Journal of Endocrinology

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Background: Helicobacter pylori, and the chronic gastric inflammation that it causes, may compromise the function and survival of ghrelin-producing cells, resulting in a decrease of circulating ghrelin levels. This finding raises the possibility that the infection might affect growth in children by reducing the ghrelin production. Aims: To determine baseline circulating levels of ghrelin and leptin in prepubertal children with and without H. pylori infection and to evaluate the long-term effects of H. pylori eradication on circulating levels of ghrelin and leptin as well as on body composition. Patients: Thirty children with H. pylori-associated gastritis, 35 children with H. pylori-negative gastric mucosa, and 20 healthy controls were studied. Results: At baseline, while leptin levels were significantly lower in H. pylori-positive patients, ghrelin concentrations did not differ among the three study groups. However, a significant inverse correlation between ghrelin concentrations and histological severity of gastritis was found. Eradication of the organism was associated with a progressive decrease in ghrelin concentrations over baseline at both 6-and 12-month follow-ups. SDS-body mass index (BMI), lean and fat mass, as well as leptin concentrations, significantly increased over baseline at both follow-ups. Conclusions: In prepubertal children, serum ghrelin concentrations are inversely related to the severity of H. pylori-associated gastritis. In these youngsters, long-term eradication of H. pylori infection is associated with a significant increase in BMI, lean and fat mass along with a significant decrease in circulating ghrelin levels and an increase in leptin levels.

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Section: Discussionsupporting

confidence: 93%

“…There are contradictory reports on the influence of H. pylori eradication on ghrelin concentrations (25,26,29,48,49). In most studies, the follow-up was too short to see any change in BMI.…”

Section: Discussionmentioning

confidence: 99%

Long-term effects of Helicobacter pylori eradication on circulating ghrelin and leptin concentrations and body composition in prepubertal children

Pacifico¹,

Anania²,

Osborn³

et al. 2008

European Journal of Endocrinology

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“…25,27 Recently, H. pylori eradication increased weight and decreased plasma ghrelin levels (but increased gastric levels) in men participating in a Japanese gastric cancer surveillance programme. 29 Large studies are now required to clarify the role of these peptides to mediate the influence of H. pylori eradication on BMI.…”

Section: Discussionmentioning

confidence: 99%

“…Participants who tested positive for H. pylori with the UBT (using a standard test meal of citric acid and orange juice with a cutoff of Cd 13 3.5 per cm 3 ) 13 were randomised either to H. pylori eradication therapy (ranitidine bismuth citrate 400 mg and clarithromycin 500 mg twice daily for 2 weeks) or to placebo. Randomisation was stratified by gender and age (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)30-39, 40-49 and 50-59 years). Staff independent of the study prepared the randomisation sequence, which was generated by computer with a block size of 10.…”

Section: Methodsmentioning

confidence: 99%

Randomised clinical trial: Helicobacter pylori eradication is associated with a significantly increased body mass index in a placebo-controlled study

Lane

Murray

Harvey

et al. 2011

Alimentary Pharmacology &Amp; Therapeutics

100

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“…Ghrelin levels increased, however, 12 weeks after successful H. pylori eradication (36)(37)(38). The density of ghrelinimmunoreactive cells was lower in the oxyntic mucosa of patients infected with H. pylori.…”

Section: Inflammatory and Infectious Gastrointestinal Diseasesmentioning

confidence: 99%

Ghrelin in gastrointestinal diseases and disorders: A possible role in the pathophysiology and clinical implications (Review)

El‐Salhy

2009

Int J Mol Med

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Abstract. Ghrelin is a peptide hormone, which has been isolated from the stomach. It is localized mostly in endocrine cells in the oxyntic mucosa of the stomach. Ghrelin receptors are expressed equally in all parts of the gastrointestinal tract, with a similar level of expression in the mucosal and muscle layers. This peptide hormone has several functions, the most widely known is its growth hormone (GH)-releasing effect. Ghrelin plays an important role in regulating appetite, feeding and energy metabolism. It also plays a role in mediating immune response and inflammatory processes. Ghrelin stimulates gastric motility and emptying as well as motility in the small and large intestine. Ghrelin has been reported to be affected in several gastrointestinal diseases/disorders such as inflammatory bowel disease, coeliac disease, infectious diseases, functional disorders and diabetes gastroenteropathy. This indicates that ghrelin is involved in the pathophysiology of gastrointestinal diseases/disorders. Several studies have shown that ghrelin and its antagonist are a promising tool for treatment of several gastrointestinal diseases/disorders.

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Changes in plasma ghrelin levels, gastric ghrelin production, and body weight after Helicobacter pylori cure

Abstract: Changes in plasma ghrelin concentrations before and after H. pylori cure were inversely correlated with body weight change and initial plasma ghrelin levels but not with gastric ghrelin production in Japanese patients.

Cited by 47 publications

References 38 publications

Long-term effects of Helicobacter pylori eradication on circulating ghrelin and leptin concentrations and body composition in prepubertal children

Long-term effects of Helicobacter pylori eradication on circulating ghrelin and leptin concentrations and body composition in prepubertal children

Randomised clinical trial: Helicobacter pylori eradication is associated with a significantly increased body mass index in a placebo-controlled study

Ghrelin in gastrointestinal diseases and disorders: A possible role in the pathophysiology and clinical implications (Review)

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