Changes in Plasma Lipids and Lipoproteins After a Modified Fat Diet

Ernst, Nancy D.; Bowen, Phyllis E.; Fisher, Marian R.; Schaefer, E J; Levy, R I

doi:10.1016/s0140-6736(80)90003-3

Cited by 75 publications

(15 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Discussionmentioning

confidence: 99%

“…Diet plays an important role in controlling blood lipids. The effect of dietary fat on blood lipids has been studied [1][2][3], but the effects on lipid-metabolizing enzymes have not been studied as such, despite the fact that these enzymes are responsible for changes in plasma lipids.Lecithin cholesterol acyl transferase (LCAT, EC 2.3.1.43) catalyzes the transfer of fatty acids from the C-2 position of lecithin to cholesterol [4]. In humans, almost all plasma cholesteryl ester is formed by the activity of this enzyme [5,6].…”

mentioning

confidence: 99%

See 1 more Smart Citation

Changes in Plasma Lecithin: Cholesterol Acyl Transferase Activity in Rats Fed a Cholesterol Diet.

Onyeneke

Alumanah

Ononogbu

1991

J. Clin. Biochem. Nutr.

View full text Add to dashboard Cite

SummaryThe effect of feeding of cholesterol equivalent to 7.692 and 10.026 mg/kg/day on plasma lecithin: cholesterol aryl transferase activity in rats was examined. The enzyme activity was increased significantly in the cholesterol-fed rats (p <0.01) when compared with the level in the control animals fed a normal diet and was found to be dose (amount of cholesterol incorporated) dependent. The former group also showed relative significant increases in the plasma levels of cholesteryl ester and lysolecithin (p<0.05) and decreased levels of lecithin (p<0.01). Changes in free cholesterol levels were, however, not statistically significant (p>0.05) in the cholesterol-fed rats. The implications of these findings are discussed with respect to atherogenesis.Although the rate of mortality has been reduced, cardiovascular disease still remains one of the leading causes of death in developed countries. Studies in this area are mostly preventive and have focused on ways of reducing plasma cholesterol by nutritional means. Diet plays an important role in controlling blood lipids. The effect of dietary fat on blood lipids has been studied [1][2][3], but the effects on lipid-metabolizing enzymes have not been studied as such, despite the fact that these enzymes are responsible for changes in plasma lipids.Lecithin cholesterol acyl transferase (LCAT, EC 2.3.1.43) catalyzes the transfer of fatty acids from the C-2 position of lecithin to cholesterol [4]. In humans, almost all plasma cholesteryl ester is formed by the activity of this enzyme [5,6]. The enzyme has been implicated in the transport of cholesterol from peripheral tissues to the liver [6,7], and individuals devoid of this enzyme [8] show abnormal plasma lipoproteins [9]. In the absence of LCAT activity, both

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Changes in Plasma Lecithin: Cholesterol Acyl Transferase Activity in Rats Fed a Cholesterol Diet.

Onyeneke

Alumanah

Ononogbu

1991

J. Clin. Biochem. Nutr.

View full text Add to dashboard Cite

show abstract

“…TG levels in these subjects ranked in the high normal range, whereas HDLC levels ranked in the lowest quintile.7 Postdiet HDLC/TC was 0. 13 and Sfi levels. Again, patient characteristics were not related to these changes.…”

Section: Resultsmentioning

confidence: 94%

The influence of changes in lipid values induced by cholestyramine and diet on progression of coronary artery disease: results of NHLBI Type II Coronary Intervention Study.

Levy¹,

Brensike²,

Epstein³

et al. 1984

Circulation

363

View full text Add to dashboard Cite

The National Heart, Lung and Blood Institute Type II Coronary Intervention Study, a double-blind, placebo-controlled trial, evaluated the efficacy of reduction in cholesterol levels induced by cholestyramine on progression of coronary artery disease (CAD). The rate of CAD progression in patients treated with cholestyramine plus diet was compared with that of patients treated with placebo plus diet. CAD progression was defined angiographically. Significant decrease in total cholesterol (TC) and low-density lipoprotein cholesterol (LDLC) and increases in high-density lipoprotein cholesterol (HDLL). as well as in HDLC/TC and HDLC/LDLC ratios, were observed with cholestyramine. HDLC change was due to increase in HDL2A and HDL2B. When the relationship between CAD progression and lipid changes was examined independent of specific treatment group, a significant inverse relationship was found between progression at 5 years and the combination of an increase in HDLC and a decrease in LDL,; changes in HDLC/TC and HDLC/LDLc were the best predictors of CAD change. While the testing of these relationships independent of treatment group was not part of the initial study design, the trends were observed in both the placebo-treated and cholestyramine-treated groups. Moreover, with multivariate analysis, the effect of cholestyramine treatment on CAD progression was eliminated by adding changes in HDLC/TC to the regression model. These findings support the hypothesis that increases in HDLC and decreases in TC (or LDLC) can prevent or delay CAD progression. Circulation 69, No. 2, 325-337, 1984 medication was prescribed, and patients were followed at monthly clinical visits over a period of 5 years. In previous articles the design and baseline findings,' the method of assessing angiographic progression of disease, and the primary end point results were reported.2 The major purpose of this report is to describe both the lipid response to treatment and the relationship between this lipid response and CAD progression. The relationship between baseline lipid levels and other characteristics, as well as the lipid response to treatment, is also explored. MethodsThe specific criteria for this study stipulated that only those subjects with elevated levels of LDLC were eligible. Serial sampling before and after a low-cholesterol, low-fat diet effectively screened out those subjects with LDLC elevations secondary to diet.' Criteria for lipid screening used in the trial are presented in table 1. Compliance to taking medication was estimated at

show abstract

“…Decreased physical activity and increased consumption of calories and saturated fat result in abdominal obesity, insulin resistance and atherogenic dyslipidaemia. (24,25) These acquired metabolic abnormalities appear to have a synergistic effect on development of CAD in genetically predisposed individuals. In western countries, through health education efforts and behaviour modification, it has been able to bring down the serum cholesterol levels and to reduce the incidence of CAD, while our population appears to be replacing the traditional vegetarian and fish-based diet with more processed foods and meat-based diet, which maybe one of the reasons for high serum lipids and thereby high risk of CAD.…”

Section: Discussionmentioning

confidence: 99%

Coronary Artery Disease Risk Factors in Women- A Study on Serum Lipids and Lipoproteins

Nair¹,

Janardhanan²,

Pillai³

2017

jemds

View full text Add to dashboard Cite

BACKGROUND Cardiovascular diseases are now the most common cause of death worldwide. Most of the risk factors for coronary artery disease were similar for both men and women, but some are unique to women. The present study was carried out to identify the presence of risk factors of CAD in a group of working women. MATERIALS AND METHODSA descriptive study was carried out in which distribution of serum lipids and other risk factors of CAD in 200 females of different age groups ranging from 20 to 60 years were assessed. The statistical analysis was performed using one-way ANOVA test and correlation study. RESULTSThe mean values for lipids are total cholesterol -184.88 ± 30.8, triglycerides -100.57 ± 38.42, LDL cholesterol -114.79 ± 32.64, HDL cholesterol -49.95 ± 10.5 and total cholesterol/HDL ratio -3.88. Comparison of the parameters in different age group shows the risk category is more in group 4, which include women in age group 46-60 yrs. CONCLUSIONThe analysis reveals that the level of total cholesterol, LDL cholesterol and triglycerides are higher in older age groups while HDL cholesterol levels are decreasing as age advances and that the women in postmenopausal age group has a more atherogenic lipid profile than premenopausal women. Those with other risk factors such as hypertension, diabetes mellitus and obesity have more atherogenic lipid profile. KEYWORDS BACKGROUNDCardiovascular disease is a major health problem in many countries. It is the leading cause of mortality in developed countries. Mortality from Coronary Artery Disease (CAD) begins later in women than in men occurring more often in postmenopausal women predominantly in their sixties and older. (1) Studies have shown a high prevalence of CAD in both urban and rural population of India. This increase in CAD rates is primarily due to the change in lifestyle, mostly the dietary changes.

show abstract

Changes in Plasma Lipids and Lipoproteins After a Modified Fat Diet

Cited by 75 publications

References 15 publications

Changes in Plasma Lecithin: Cholesterol Acyl Transferase Activity in Rats Fed a Cholesterol Diet.

Changes in Plasma Lecithin: Cholesterol Acyl Transferase Activity in Rats Fed a Cholesterol Diet.

The influence of changes in lipid values induced by cholestyramine and diet on progression of coronary artery disease: results of NHLBI Type II Coronary Intervention Study.

Coronary Artery Disease Risk Factors in Women- A Study on Serum Lipids and Lipoproteins

Contact Info

Product

Resources

About