Changes in plasma lipoproteins and liver lipids in neonatal rats

García-Molina, Virginia Aparicio; Aguilera, J.A.; Gil, Ángel; Sánchez–Pozo, Antonio

doi:10.1016/0305-0491(95)02115-9

Cited by 7 publications

(3 citation statements)

References 29 publications

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“…All lipids of VLDL increased with age in control and obese rats with marked changes during the first month of life. Consistent with previous reports in humans and in animals (33,34), these lipoprotein changes were due to increased lipid synthesis after birth. Indeed, a significant age effect in the fatty acid composition was seen in all groups.…”

Section: Discussionsupporting

confidence: 92%

Age‐Related Changes in Fatty Acids in Obese Offspring of Streptozotocin‐Induced Diabetic Rats

et al. 2002

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MERZOUK, HAFIDA, SIHEM MADANI, AZIZ HICHAMI, JOSIANE PROST, JACQUES BELLEVILLE, AND NAIM A. KHAN. Age-related changes in fatty acids in obese offspring of streptozotocin-induced diabetic rats. Obes Res. 2002;10:703-714. Objective: The long-term effects of fetal hyperinsulinemia, time course of changes in liver and very-low-density lipoprotein (VLDL) lipid levels and fatty acid compositions were investigated in obese offspring of streptozotocin-induced mildly diabetic rats. Research Methods and Procedures: Mild hyperglycemia in pregnant rats was induced by intraperitoneal injection of streptozotocin on day 5 of gestation. Control pregnant rats were injected with citrate buffer. Liver and VLDL lipids and fatty acids were analyzed in offspring at different ages. Results: At birth, obese pups had higher VLDL triglyceride levels, saturated fatty acids, and C20:4n-6. They also had lower C18:2n-6 proportions in VLDL triglycerides, phospholipids, and cholesteryl esters than controls pups. In 1-month-old male and female obese rats, VLDL and liver lipid amounts were similar to those in their respective controls; however, high levels of C18:2n-6 and C20:4n-6 were noted in liver and VLDL lipids. At the age of 2 months, liver and VLDL triglyceride levels were higher in obese females than in control females. Fatty acid abnormalities seen in obese rats included low C18:3n-3 and high C22:6n-3 proportions in liver triglycerides and phospholipids. At the age of 3 months, obese rats, both males and females, compared with control animals, had higher VLDL and hepatic lipids with reduced C20:4n-6 levels and polyunsaturated/saturated fatty acids ratios in hepatic and VLDL triglycerides and phospholipids. Discussion: Fetal obesity, associated with alterations in VLDL lipid fatty acid composition, represents an important risk factor for adult obesity and diabetes.

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Section: Discussionsupporting

confidence: 92%

Age‐Related Changes in Fatty Acids in Obese Offspring of Streptozotocin‐Induced Diabetic Rats

et al. 2002

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“…Dietary nucleotides are known to play many biochemical and physiological roles, serving as precursors for nucleic acid synthesis, being involved in protein synthesis and influencing lipid and lipoprotein metabolism (24)(25)(26). Recently, we found that the levels of plasma apolipoprotein A-IV, which is of intestinal origin, was increased by dietary nucleotide supplementation in newborn infants (Pediatr.…”

Section: Resultsmentioning

confidence: 99%

Maturation status of small intestine epithelium in rats deprived of dietary nucleotides

1995

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SummarvWe describe the changes of several brush-border enzymatic activities in different subpopulations of epithelial cells, separated sequentially from the villus tip-to-crypt axis of the small intestine, induced by deprivation of dietary nucleotides for different periods of time in adult rats. Deprivation of dietary nucleotides lead to a decrease in the content and specific activity of alkaline phosphatase, leucineaminopeptidase, maltase, sucrase and lactase in the villus tip, but had little effect on the crypt zone. The effect of the nucleotide deprivation on the enzymatic activity progressively increased towards the tip of the villus. Since these enzymes are maturation markers of the intestinal cells, these results support the idea that dietary nucleotides affect the maturation status of small-intestine epithelium.

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“…SREBP-1c content might be increased in macrosomic newborns. Because the HDL fraction is primarily responsible for lipid transport dur- ing fetal life in humans (30) and in rats (31), elevated LDL-HDL 1 and HDL 2-3 cholesterol concentrations might reflect an increase in required cholesterol for membrane, hormone, and surfactant synthesis in macrosomic newborns.…”

Section: Discussionmentioning

confidence: 99%

Age-related changes in cholesterol metabolism in macrosomic offspring of rats with streptozotocin-induced diabetes

Merzouk

Madani

Boualga

et al. 2001

Journal of Lipid Research

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The aim of this study was to determine the impact of diabetic macrosomia on cholesterol and lipoprotein metabolism. Age-related changes in the activities of serum LCAT, hepatic HMG-CoA reductase, cholesterol 7 ␣ -hydroxylase, and ACAT, the major enzymes involved in cholesterol metabolism, were determined in macrosomic offspring of streptozotocin-induced diabetic rats. Hepatic, serum, and lipoprotein cholesterol contents were also examined. Mild hyperglycemia in pregnant rats was induced by intraperitoneal injection of streptozotocin (40 mg/kg body weight) on day 5 of gestation. Control pregnant rats were injected with citrate buffer. At birth, macrosomic pups had higher serum, LDL-HDL 1 , and HDL 2-3 cholesterol levels ( P Ͻ 0.05) associated with increased LCAT activity ( ϩ 57%) compared with control values. At 1 and 2 months of life, serum and lipoprotein cholesterol concentrations in macrosomic rats were similar to those of controls, whereas LCAT activity remained elevated about 1.5-fold. In addition, there was no change in hepatic cholesterol contents but hepatic HMG-CoA reductase, cholesterol 7 ␣ -hydroxylase, and ACAT activities were higher in both macrosomic males and females than in their respective controls ( P Ͻ 0.01). By 3 months, macrosomic rats had developed hypercholesterolemia with a rise in all lipoproteins. Enzyme activities were still increased in these mature macrosomic rats, and hepatic cholesteryl esters were higher only in macrosomic females. These data demonstrate an overproduction, combined with overutilization, of cholesterol during the phase of rapid growth in macrosomic rats. However, cholesterol oversynthesis exceeded its removal and was a major contributor to hypercholesterolemia in adult macrosomic rats. In conclusion, macrosomia was associated with alterations in cholesterol metabolism through adulthood. -Merzouk, H., S. Madani, A. Boualga, J. Prost, M. Bouchenak, and J. Belleville. Age-related changes in cholesterol metabolism in macrosomic offspring of rats with streptozotocin-induced diabetes.

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Changes in plasma lipoproteins and liver lipids in neonatal rats

Cited by 7 publications

References 29 publications

Age‐Related Changes in Fatty Acids in Obese Offspring of Streptozotocin‐Induced Diabetic Rats

Age‐Related Changes in Fatty Acids in Obese Offspring of Streptozotocin‐Induced Diabetic Rats

Maturation status of small intestine epithelium in rats deprived of dietary nucleotides

Age-related changes in cholesterol metabolism in macrosomic offspring of rats with streptozotocin-induced diabetes

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