Changes in plasma urate, creatinine, alkaline phosphatase and the 24 hour excretion of hydroxyproline during sexual maturation in adolescents

Jm, Round

doi:10.1080/03014468000004071

Cited by 12 publications

(5 citation statements)

References 20 publications

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“…44, 45 As significant differences in uric acid levels between male and female adolescents were noted in this and previous studies, the association between uric acid level and elevated blood pressure was examined stratified by sex. 44-47 Males had a higher odds than females of having an elevated blood pressure with increasing uric acid level. It is likely that the lower uric acid levels observed in females in the cohort may be diluting the association with elevated blood pressure, as an interaction between uric acid and sex was not statistically significant.…”

Section: Discussionmentioning

confidence: 79%

Uric Acid Level and Elevated Blood Pressure in US Adolescents

et al. 2012

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Uric acid is associated with cardiovascular disease (CVD) and CVD risk factors in adults, including chronic kidney disease, coronary artery disease, stroke, diabetes, preeclampsia, and hypertension. We examined the association between uric acid and elevated blood pressure in a large, nationally representative cohort of U.S. adolescents, a population with a relatively low prevalence of CVD and CVD risk factors. Among 6,036 adolescents 12-17 years of age examined in the 1999-2006 National Health and Nutrition Examination Survey (NHANES) the mean age was 14.5 years, 17% were obese (body mass index [BMI] ≥95th percentile), and 3.3% had elevated blood pressure. Mean serum uric acid level was 5.0 mg/dL and 34% had a uric acid level ≥5.5 mg/dL. In analyses adjusted for age, sex, race/ethnicity and BMI percentile, the odds ratio of elevated blood pressure, defined as a systolic or diastolic blood pressure ≥95th percentile for age, sex and height, for each 0.1 mg/dL increase in uric acid level was 1.38 (95% confidence interval [CI], 1.16 to 1.65). Compared to <5.5 mg/dL, participants with a uric acid level ≥5.5 mg/dL had a 2.03 times higher odds of having elevated blood pressure (95% CI, 1.38 to 3.00). In conclusion, increasing levels of serum uric acid are associated with elevated blood pressure in healthy U.S. adolescents. Additional prospective studies and clinical trials are needed to determine if uric acid is merely a marker in a complex metabolic pathway, or causal of hypertension and thus a potential screening and therapeutic target.

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Section: Discussionmentioning

confidence: 79%

Uric Acid Level and Elevated Blood Pressure in US Adolescents

et al. 2012

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“…In the present study a clear sex difference was observed. Since serum uric acid is known to vary with sex (Munan, Kelly and Petitclerc 1976, (Mikkelsen et al 1965, Bengtsson andTibblin 1974), and sexual maturity (Round 1980), this suggests that these variables, along with height and weight, need to be considered in future studies of uric acid and blood pressure in adolescents.…”

Section: Serum Uric Acid and Blood Pressurementioning

confidence: 97%

“…This rise in uric acid occurred to the same extent in both black and white youths; however, the white youths reached their adult plateau at 15 while the black youths reached it at 16-17. Round (1980) examined the association of serum uric acid levels and the sexual maturity of boys and girls. She found increases in uric acid in males but not in females to be associated with increasing sexual maturity.…”

Section: Introductionmentioning

confidence: 99%

Relation between serum uric acid and blood pressure in adolescents

Goldstein¹,

Manowitz²

1993

Annals of Human Biology

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In adults, serum uric acid is positively associated with blood pressure levels. It is also a predictor of the development of hypertension in normotensive adults. The purpose of this study was to examine the relation of serum uric acid to systolic and diastolic blood pressure in adolescents. The data, from Cycle III of the National Health Examination Survey, consisted of a national probability sample of 6768 youths, 12-17 years old, in the United States. With age, height, weight, and sexual maturity controlled, serum uric acid significantly predicted blood pressure in adolescents. This relationship of uric acid and blood pressure was evident in male, but not female, adolescents. In association with findings from adult studies, these results indicate that uric acid levels may be useful indicators of adolescents at risk for hypertension.

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“…For a clinical description of these conditions, see Chapter 14. bTNAP is secreted by osteoblasts and promotes bone mineralisation. Circulating TNSAP is largely derived from liver and bone, and its levels in plasma during childhood reflect the growth rate [55] and are raised in the presence of rickets (see Chapter 8), in Juvenile Paget's Disease (#239000) and in fibrous dysplasia (see Chapter 14). Low TNSAP levels are seen in hypophosphatasia, which results from mutations in the TNAP gene.…”

Section: Alkaline Phosphatasementioning

confidence: 99%

Physiology of Calcium, Phosphate, Magnesium and Vitamin D

Allgrove

2015

Endocrine Development

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The physiology of calcium and the other minerals involved in its metabolism is complex and intimately linked to the physiology of bone. Five principal humoral factors are involved in maintaining plasma concentrations of calcium, magnesium and phosphate and in coordinating the balance between their content in bone. The transmembrane transport of these elements is dependent on a series of complex mechanisms that are partly controlled by these hormones. The plasma concentration of calcium is initially sensed by a calcium-sensing receptor, which then sets up a cascade of events that initially determines parathyroid hormone secretion and eventually results in a specific action within the target organs, mainly bone and kidney. This chapter describes the physiology of these humoral factors and relates them to the pathological processes that give rise to disorders of calcium, phosphate and magnesium metabolism as well as of bone metabolism. This chapter also details the stages in the calcium cascade, describes the effects of calcium on the various target organs, gives details of the processes by which phosphate and magnesium are controlled and summarises the metabolism of vitamin D. The pathology of disorders of bone and calcium metabolism is described in detail in the relevant chapters.

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Changes in plasma urate, creatinine, alkaline phosphatase and the 24 hour excretion of hydroxyproline during sexual maturation in adolescents

Cited by 12 publications

References 20 publications

Uric Acid Level and Elevated Blood Pressure in US Adolescents

Uric Acid Level and Elevated Blood Pressure in US Adolescents

Relation between serum uric acid and blood pressure in adolescents

Physiology of Calcium, Phosphate, Magnesium and Vitamin D

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