Changes in Platycoside Components and Antimicrobial Activities of Bronchus Disease-Inducing Bacteria of Fermented Platycodon grandiflorum Root by Lactic Acid Bacteria

이가순,; 성봉재,; 김선익,; 지무근,; 박샛별,; 박명희,; 박신영,; 김현호,

doi:10.3746/jkfn.2016.45.7.1017

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…PG root has multiple active ingredients, such as phenolic acid, flavonoids and sterols. These include 17 saponins [ 45 , 46 ], among which platycodin D, deapi-platycodin D, platycoside E, polygalacin D2 and polygalacin D are important. Platycoside E ameliorated ethanol-induced cognitive impairment in mice [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Crude Saponin from Platycodon grandiflorum Attenuates Aβ-Induced Neurotoxicity via Antioxidant, Anti-Inflammatory and Anti-Apoptotic Signaling Pathways

Kim

et al. 2021

Antioxidants

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(1) Background: Although Platycodon grandiflorum saponins exhibit many beneficial biological effects in various diseases and conditions, how they protect nerve cells against neurodegenerative diseases and Alzheimer’s disease (AD) pathology is unknown. We investigated whether P. grandiflorum crude saponin (PGS) protects neurons from neurodegeneration caused by amyloid beta (Aβ)-induced oxidative stress. (2) Methods: Hippocampal neuron HT-22 cells were used in the in vitro experiment, and AD mice (5XFAD mice) were used as the in vivo model. Intracellular reactive oxygen species (ROS) was stained with DCF-DA and assessed using fluorescence microscopy. To elucidate the mechanism underlying neuroprotection, intracellular protein levels were assessed by western blotting. In 5XFAD mice, an animal model of AD, nerve damage recovery due to the induction of Aβ toxicity was evaluated by histological analysis. (3) Results: PGS attenuates Aβ-induced neurotoxicity by inhibiting Aβ-induced reactive oxygen species (ROS) production and apoptosis in HT-22 cells. Furthermore, PGS upregulated Nrf2-mediated antioxidant signaling and downregulated NF-κB-mediated inflammatory signaling. Additionally, PGS inhibited apoptosis by regulating the expression of apoptosis-associated proteins. In addition, PGS ameliorated Aβ-mediated pathologies, leading to AD-associated cognitive decline. (4) Conclusions: Taken together, these findings suggest that PGS inhibits Aβ accumulation in the subiculum and cerebral cortex and attenuates Aβ toxicity-induced nerve damage in vitro and in vivo. Therefore, PGS is a resource for developing AD therapeutics.

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Section: Discussionmentioning

confidence: 99%

Crude Saponin from Platycodon grandiflorum Attenuates Aβ-Induced Neurotoxicity via Antioxidant, Anti-Inflammatory and Anti-Apoptotic Signaling Pathways

Kim

et al. 2021

Antioxidants

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“…Korean researchers reported that platycosides content of P. grandiflorum roots fermented by lactic acid bacteria such as Leuconostoc plantarum N56-12 was higher than the non-fermented extract. The results demonstrated that the fermented had more antibacterial action against bacteria that cause bronchus illness than the non-fermented did ( Lee et al, 2016a ).…”

Section: Biotransformation Of Platycosides In Vitromentioning

confidence: 99%

Biotransformation and pharmacological activities of platycosides from Platycodon grandiflorum roots

Shi,

Cui,

Wang

et al. 2024

Chinese Herbal Medicines

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Optimization of the Hot Water Extracting Conditions for the Bell Flower Root (Platycodon grandiflorum A. DC.) Using the Response Surface Methodology

Kim

2023

JKFN

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Previous studies on the bell flower root (Platycodon grandiflorum A. DC.) were conducted using hot water extraction under simple conditions or using organic solvents for enhancing efficacy, processing, and commercialization. However, this study investigated the optimal conditions for hot water extraction for utilizing each useful component of the bell flower root. The bell flower root hot water extraction conditions were optimized using a response surface methodology (RSM). A central composite design was applied to examine the effects of three independent variables, namely, solvent-to-sample ratio, extraction temperature, and extraction time. The extraction conditions were optimized with the characteristics of the extracts as a dependent variable. These characteristics included extraction yield, total sugar, reducing sugar contents, crude saponin contents, and platycodin D contents. The optimal conditions based on the superimposing of the four-dimensional RSM on the crude saponin and platycodin D contents under various conditions were established. As a result of verifying the significance of the predicted value of each component under optimal extraction conditions with the actual measured value, there was no significant difference between the predicted value and the actual measured value. It is expected that effective extraction and use of each component of the bell flower root extracts will be possible using these optimal extraction conditions.

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Changes in Platycoside Components and Antimicrobial Activities of Bronchus Disease-Inducing Bacteria of Fermented Platycodon grandiflorum Root by Lactic Acid Bacteria

Cited by 3 publications

References 17 publications

Crude Saponin from Platycodon grandiflorum Attenuates Aβ-Induced Neurotoxicity via Antioxidant, Anti-Inflammatory and Anti-Apoptotic Signaling Pathways

Crude Saponin from Platycodon grandiflorum Attenuates Aβ-Induced Neurotoxicity via Antioxidant, Anti-Inflammatory and Anti-Apoptotic Signaling Pathways

Biotransformation and pharmacological activities of platycosides from Platycodon grandiflorum roots

Optimization of the Hot Water Extracting Conditions for the Bell Flower Root (Platycodon grandiflorum A. DC.) Using the Response Surface Methodology

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