Changes in pro/antioxidant balance in smoking and non-smoking pregnant women with intrauterine growth restriction

Bizoń, Anna; Milnerowicz-Nabzdyk, Ewa; Zalewska, Marta; Zimmer, Mariusz; Milnerowicz, Halina

doi:10.1016/j.reprotox.2011.08.007

Cited by 28 publications

(28 citation statements)

References 39 publications

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“…Data in the literature indicate there is a close correlation between smoking and the level of weight deficiency [4,13,15]. This is also consistent with the authors' previous study, where weight deficit increased with rising maternal blood cotinine levels [19]. A similar situation occurs in the case of umbilical flow parameters increasing with exceeding exposure levels.…”

Section: Discussionsupporting

confidence: 87%

“…The present study is a continuation of the previously performed research [12,19], however those work focused on a different aspect of the impact of smoking on pregnancy complicated by IUGR. The study group in all three works was similar, although this study was performed on a larger group of subjects.…”

Section: Methodsmentioning

confidence: 87%

“…Milnerowicz-Nabzdyk et al focused solely on morphological aspects of umbilical cords, and the smoker group was studied along with other pregnancies complicated by IUGR [12]. Bizon et al extensively analyzed the effect of cigarette smoking on antioxidant status [19]. In the present study, biochemical blood findings of pregnant women and fetuses exposed to tobacco smoke were correlated with the results of Doppler flow measurements in fetal and maternal blood vessels, essential for assessment of fetal well-being.…”

Section: Methodsmentioning

confidence: 92%

“…The best marker of current exposure to tobacco smoke is cotinine, one of the nicotine metabolites [18,19], while cadmium (Cd) is a marker of both long-term and recent exposure, as the element accumulates in the bodies of both mother and fetus. Metallothionein (MT) and glutathione (GSH) are antioxidants known to participate in mechanisms responsible for detoxification of tobacco smoke components [2,19,20].…”

Section: Introductionmentioning

confidence: 99%

“…Metallothionein (MT) and glutathione (GSH) are antioxidants known to participate in mechanisms responsible for detoxification of tobacco smoke components [2,19,20].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Effect of cigarette smoking on vascular flows in pregnancies complicated by intrauterine growth restriction

Milnerowicz-Nabzdyk

Bizoń

2014

Reproductive Toxicology

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Section: Discussionsupporting

confidence: 87%

Section: Methodsmentioning

confidence: 87%

Section: Methodsmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

“…Metallothionein (MT) and glutathione (GSH) are antioxidants known to participate in mechanisms responsible for detoxification of tobacco smoke components [2,19,20].…”

Section: Introductionmentioning

confidence: 99%

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Effect of cigarette smoking on vascular flows in pregnancies complicated by intrauterine growth restriction

Milnerowicz-Nabzdyk

Bizoń

2014

Reproductive Toxicology

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The role of metallothionein interactions with other proteins

2014

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Metallothionein (MT) is a protein involved in numerous key processes, and the most important include zinc ion homeostasis, detoxification of heavy metals, and protection against oxidative stress. MT by interaction with other proteins fulfills its function, resulting in different effects in the body. Interaction of MT with ferritin, which causes a redox reaction, resulting in the reduction of Fe(3+) stored in ferritin and a release of harmful Fe(2+) , was observed. Referring to the redox function of MT, it has been shown that the pair of GSH/GSSG modulates transfer of Zn between MT and Zn-binding proteins. Furthermore, it was shown that GSSG, in the presence of GSH, interacts directly with MT. Apothionein-MT can retrieve Zn from the transcription factors or Zn-containing enzymes. Apothionein-MT by taking Zn can deactivate metal-dependent enzymes while Zn-MT has the opposite effect. As the effect of MT interaction with low-density lipoprotein receptors-megalin and lipoprotein receptor related protein 1, the uptake of Cd-MT occurs and results in the disruption of many functions of proximal tubules. MT is involved in numerous processes and many of them are regulated by protein-protein interactions. Possibly in the future MT will become a therapeutic agent, which will result in a breakthrough in the field of pharmacy and medicine.

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Perinatal complications, lipid peroxidation, and mental health problems in a large community pediatric sample

Mansur

Cunha

Asevedo

et al. 2016

Eur Child Adolesc Psychiatry

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Replicated evidence indicates that perinatal complications are associated with increased markers of oxidative stress and with mental health problems in children. However, there are fewer reports on the impact of perinatal complications in later phases of development. We aimed to investigate the estimated effects of perinatal complications on levels of lipid peroxidation and on psychopathology in children and adolescents. The study is part of the High Risk Cohort Study for Psychiatric Disorders; the population was composed by 554 students, 6-14 years of age. Serum levels of malondialdehyde, a product of lipid peroxidation, were measured by the TBARS method. A household interview with parents and caregivers was conducted and included inquiries about perinatal history, the Child Behavior Checklist (CBCL), and parent's evaluation, using the Mini International Psychiatric Interview (MINI). We created a cumulative risk index, conceptualized as each individual's cumulative exposure to perinatal complications. Results indicate that perinatal complications were associated with higher levels of TBARS. After adjusting for age, gender, socio-economic status, CBCL total problems score, parental psychopathology, and childhood maltreatment, children exposed to 3 or more perinatal complications had an 26.9% (95% CI 9.9%, 46.6%) increase in TBARS levels, relative to the unexposed group. Exploratory mediation analysis indicated that TBARS levels partially mediated the association between perinatal complications and externalizing problems. In conclusion, an adverse intrauterine and/or early life environment, as proxied by the cumulative exposure to perinatal complications, was independently associated with higher levels of lipid peroxidation in children and adolescents.

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Changes in pro/antioxidant balance in smoking and non-smoking pregnant women with intrauterine growth restriction

Cited by 28 publications

References 39 publications

Effect of cigarette smoking on vascular flows in pregnancies complicated by intrauterine growth restriction

Effect of cigarette smoking on vascular flows in pregnancies complicated by intrauterine growth restriction

The role of metallothionein interactions with other proteins

Perinatal complications, lipid peroxidation, and mental health problems in a large community pediatric sample

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