Changes in Prostaglandin E&lt;sub&gt;2&lt;/sub&gt; Levels in Seminal Plasma during Ejaculation and the Effect of Exogenous Prostaglandin E&lt;sub&gt;2&lt;/sub&gt; on Semen Volume in the Dog

Kobayashi, Masanori; Hori, Tatsuya; Kawakami, Eiichi

doi:10.1292/jvms.13-0053

Cited by 11 publications

(10 citation statements)

References 18 publications

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“…Present results agree with previous reports, concerning basal PW exam (Freitas et al., ; Günzel‐Apel et al., ; Newell et al., ; Zelli et al., ) as well as blood testosterone before and after ejaculation (Kobayashi, Hori, & Kawakami, ). To the authors’ knowledge, PW prostatic parameters after ejaculation and prostatic vessels MV were never previously evaluated.…”

Section: Discussionsupporting

confidence: 93%

Ejaculation effect on blood testosterone and prostatic pulsed‐wave Doppler ultrasound in dogs

Alonge

Melandri

Leoci

et al. 2018

Reprod Domestic Animals

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Contents Local vessels ultrasonography evaluates prostatic physio‐pathologic states. Testosterone promotes tissue and vascular growth. Knowing variables on prostatic vasculature is crucial to correctly apply Pulsed‐Wave exam. The study aims to assess how ejaculation and blood testosterone affect Pulsed‐Wave indexes. Serial blood testosterone dosages and Pulsed‐Wave exams were performed in 20 dogs, immediately before (T0) and after (T1) ejaculation and 6 hr later (T2). Arteria prostatica cranialis, Arteriola capsularis, Arteriola trabecularis and Arteriola parenchimalis were evaluated and mean Pulsatility and Resistivity Index, Systolic‐Peak, End‐Diastolic and Mean Velocity calculated. Data were grouped by time and vessel (ANOVA, p ≤ 0.05). At T1, Resistivity Index significantly lowered in A. prostatica cranialis, A. trabecularis and A. parenchimalis but grew in A. capsularis; Pulsatility Index had the same pattern, but not significant in A. parenchimalis; Systolic Peak Velocity, End‐Diastolic Velocity, Mean Velocity significantly rose in A. capsularis and A. trabecularis. No indexes differed at T0 and T2. Testosterone did not differ at T0 (10.93 ± 7.05 ng/ml), T1 (12.71 ± 7.29) and T2 (10.54 ± 6.63). Results stated the risen prostatic vascular flow postejaculation, affecting Pulsed‐Wave. Due to semi‐rigid capsule, impairing vasodilation of other vessels, only A. capsularis indexes increased. Intimal cushions of A. prostatica cranialis kept velocities fixed; A. capsularis and A. trabecularis lack of intimal cushions, thus velocities grew. In A. parenchimalis, precapillary sphincters opening allows increased flow redistribution in vasodilated parenchymal bed, keeping velocities fixed. As testosterone, not affected by ejaculation, did not peak, vascular changes are not due to testosterone itself. These physiological effects of ejaculation suggest proper sexual rest before Pulsed‐Wave exam planned to explore suspected prostatic neovascularization.

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Section: Discussionsupporting

confidence: 93%

Ejaculation effect on blood testosterone and prostatic pulsed‐wave Doppler ultrasound in dogs

Alonge

Melandri

Leoci

et al. 2018

Reprod Domestic Animals

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“…There by preventing the conversion of testosterone to dihydrotestosterone. In this way omega 3 prevent the reduction of plasma testosterone level [71] . However, it appears that the increase in testosterone levels with omega-3 was due to its direct effect on Leydig cells.Omega-3 contains alpha linolenic acid, which can be converted to arachidonic acid, as a precursor to make type 2 prostaglandins like E2 [72] .…”

Section: Discussionmentioning

confidence: 97%

The possible protective effect of Omega 3 fatty acids against Bisphenol A induced disruption of pituitary-testicular axis in albino rat. Biohemical, Histological and Immunohistochemical study

Mahmoud

Nor-Eldin

Elsayed

2019

Egyptian Journal of Histology

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Background: Infertility is a major health problem affecting human life. Multiple factors contribute to male infertility. The most important one is exposure to environmental contaminants (e.g. Bisphenol A (BPA)). Aim of the work: To study the possible protective effect of Omega 3 against BPA induced changes in the pituitary testicular axis in rats. Material and method: 30 adult male albino rats were used in the study. They were divided equally into 3 groups 10 animals each. Group I served as control. Group II received BPA in a dose 1.2 mg/kg orally 6 days a week. Group III received Omega 3 in a dose 0.4 g/kg subcutaneously in addition to BPA of the same previous dose and duration. At the time of sacrifice, all rats were anesthetized with ether.Blood samples were collected for estimation of testosterone, LH, FSH and prolactin. The testes and pituitary were dissected out and processed for histological and immunohistochemical study for Caspase 3, PCNA and prolactin. The number of Caspase 3 and PCNA positive cells were counted and statistically analyzed. Results: Marked decrease in serum LH, testosterone with marked increase in serum prolactin was observed in BPA treated group. Spermatogenic cells were disorganized and degenerated. Spermatids had fragmented pyknotic nuclei. A significant increase in the rate of apoptosis and a significant decrease in the rate of proliferation of germ cells were detected on BPA exposure compared to the control. Examination of pars distalis revealed degenerative changes in acidophils and basophils in group II animals with decreased intensity of reactive mammotrophs. These changes were ameliorated in group III by administration of Omega 3 fatty acids. Conclusion: Omega 3 may protect against BPA hazardous effects through pituitary testicular axis pathway.

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“…However, it appears that the increase in testosterone levels with walnut leaf extract was due to its direct effect on Leydig cells, as well as its interference with the biosynthesis of testosterone which was probably through stimulating the synthesis of prostaglandins series [1]. Walnut kernels contain alphalinolenic acid, which can be converted to arachidonic acid, as a precursor for the synthesis of type-2 prostaglandins such as E2 [23]. Results of effect of the extract of walnut leaves on epididymis concentration epididymis concentration are shown in Table 2 and Figure 6.…”

Section: Figure 5 Effect Of Methanol Extract Of Walnut Leaves On Tesmentioning

confidence: 99%

Effect of Black Walnut (<i>Tetracarpidium conophorum</i>) Leaf Extract on the Reproductive Organ of Male Albino Rats

Chijioke¹

2017

IJHNM

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This study determined the effect of Tetracarpidium conophorum (black walnut) leaf extract on the male reproductive organs of albino rats. The effects of the leaf extracts were determined on the Epididymal sperm concentration, Testicular histology, and on testosterone concentration in the rat serum by a micro plate enzyme immunoassay (Testosterone assay). A total of sixteen (16) male albino wistar rats were divided into four (1, 2, 3 and 4) groups of four rats each. Group 1 served as the control and was fed with normal diet only, while groups 2, 3 and 4 were fed with 200, 400 and 600 mg/kg body weight (BW) of the extract for a period of two weeks. The Epididymal sperm concentration were not significantly affected (p>0.05) across the groups. The level of testosterone for the treatment groups 2 and 4 showed no significant difference (p>0.05) compared to the control while group 4 showed significant increase compared to that of the control (p<0.05). Pathologic changes were observed in testicular histology across the treatment groups. Robust seminiferous tubular lumen containing sperm cells and increased production of Leydig cells and Sertoli cells were observed across different treatment groups compared to that of the control.

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Changes in Prostaglandin E<sub>2</sub> Levels in Seminal Plasma during Ejaculation and the Effect of Exogenous Prostaglandin E<sub>2</sub> on Semen Volume in the Dog

Cited by 11 publications

References 18 publications

Ejaculation effect on blood testosterone and prostatic pulsed‐wave Doppler ultrasound in dogs

Ejaculation effect on blood testosterone and prostatic pulsed‐wave Doppler ultrasound in dogs

The possible protective effect of Omega 3 fatty acids against Bisphenol A induced disruption of pituitary-testicular axis in albino rat. Biohemical, Histological and Immunohistochemical study

Effect of Black Walnut (<i>Tetracarpidium conophorum</i>) Leaf Extract on the Reproductive Organ of Male Albino Rats

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Changes in Prostaglandin E<sub>2</sub> Levels in Seminal Plasma during Ejaculation and the Effect of Exogenous Prostaglandin E<sub>2</sub> on Semen Volume in the Dog

Cited by 11 publications

References 18 publications

Ejaculation effect on blood testosterone and prostatic pulsed‐wave Doppler ultrasound in dogs

Ejaculation effect on blood testosterone and prostatic pulsed‐wave Doppler ultrasound in dogs

The possible protective effect of Omega 3 fatty acids against Bisphenol A induced disruption of pituitary-testicular axis in albino rat. Biohemical, Histological and Immunohistochemical study

Effect of Black Walnut (&lt;i&gt;Tetracarpidium conophorum&lt;/i&gt;) Leaf Extract on the Reproductive Organ of Male Albino Rats

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Effect of Black Walnut (<i>Tetracarpidium conophorum</i>) Leaf Extract on the Reproductive Organ of Male Albino Rats