Changes in pulmonary artery systolic pressure and right ventricular function in patients with end‐stage renal disease on maintenance dialysis

Santosh, Sadashiv; Chu, Chi Ming; Mwangi, John; Narayan, Melin; Mosman, Amy; Nayak, Ravi; Philipneri, Marie

doi:10.1111/nep.13183

Cited by 19 publications

(25 citation statements)

References 34 publications

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“…Regarding the risk factors associated with survival, age, diabetes [ 13 , 19 – 21 ], serum albumin [ 19 ], BMI [ 13 ], and cardiovascular disease [ 21 , 22 ] were not consistent with our results. Importantly, age is one of the major factors affecting survival in dialysis patients, which is consistent with our findings.…”

Section: Discussioncontrasting

confidence: 76%

Effects of dialysis modality choice on the survival of end-stage renal disease patients in southern China: a retrospective cohort study

Hou

Zhang

et al. 2020

BMC Nephrol

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Background The optimal choice of treatment, with hemodialysis (HD) or peritoneal dialysis (PD), for end-stage renal disease (ESRD) patients, is still controversial. Only a few studies comparing HD and PD have been conducted in China, which has the largest number of dialysis patients in the world. Methods A retrospective cohort study was conducted on ESRD patients who began renal replacement treatment from January 1, 2012 to December 31, 2017 in Guangdong Provincial Hospital of Chinese Medicine. Propensity scoring match was applied to balance the baseline conditions and multivariate Cox regression analysis to compare the mortality between HD and PD patients, and evaluated the correlation between mortality and various baseline characteristics. Results A total of 436 HD patients and 501 PD patients were included in this study, and PD patients had better survival than HD patients, but the difference was not statistically significant. For younger ESRD patients (≤60-year-old), the overall survival of PD was better than that of HD, but HD was associated with a lower risk of death in older patients (> 70-year-old). This difference was still significant after adjustment for a variety of confounding factors. Female gender, age at dialysis initiation, cardiovascular disease, cholesterol, and HD were risk factors of all-cause mortality in the younger subgroup, while PD was risk factor in the older subgroup. Conclusion PD may be a better choice for younger ESRD patients, and HD for the older patients.

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Section: Discussioncontrasting

confidence: 76%

Effects of dialysis modality choice on the survival of end-stage renal disease patients in southern China: a retrospective cohort study

Hou

Zhang

et al. 2020

BMC Nephrol

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“…Hypercholesterolemia was associated with increased mortality in HD patients without myocardial infarction/ cardiovascular disease 18 . Higher pulmonary artery systolic pressure predicted development of right ventricular dysfunction, which portends a poor prognosis 20 .…”

Section: Discussionmentioning

confidence: 99%

Effects of dialysis modality choice on survival of end-stage renal disease patients in southern China: A retrospective cohort study

Zhang

et al. 2020

Preprint

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Background Up to date, whether hemodialysis (HD) or peritoneal dialysis (PD) is a better choice for end-stage renal disease (ESRD) patients has been debatable. Few study comparing HD and PD was from China, a large country with the largest number of dialysis patients in the world. Method A retrospective cohort study was conducted on ESRD patients who began renal replace treatment from January 1st, 2012 and December 31st, 2017 in Guangdong Provincial Hospital of Chinese Medicine. We used propensity scoring match model to balance the baseline conditions and Cox's multivariate regression analysis to compare mortality between HD and PD patients, and evaluated the relationship between mortality and various baseline covariates. Results 436 HD patients and 501 PD patients were included and we found that PD patients had better survival than HD patients (The 1-, 3- and 5-year survival rates were 98.1% vs 96.4%, 86.7% vs 83.0%, and 73.4% vs 71.9%), even though the difference was not statistically significant. For younger ESRD patients (<=60 years old), the overall survival of PD was better than that of HD, but HD was associated with lower risk of death in the patients who were older than 70 years of age. This difference was still significant after adjustment for a variety of confounding factors. Female, cardiovascular disease, cholesterol, and HD are risk factors of all-cause mortality in the younger subgroup while PD is risk factor in the older subgroup. Conclusion Younger ESRD patients may be more suitable for PD, and the elderly for HD.

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Section: Discussionmentioning

confidence: 99%

“…Right ventricular dysfunction and PH defined as a mean pulmonary arterial pressure ≥ 25 mmHg are common complications in patients on conventional hemodialysis and peritoneal dialysis. 1,2 Yet, studies of right ventricular function and PH in patients undergoing dialysis are scarce. Two studies reported on reduction of left and right ventricular end systolic volumes and reduction of right ventricular end-systolic volume index after hemodialysis was intensified.…”

Section: Discussionmentioning

confidence: 99%

Correction of pulmonary hypertension with intensive hemodialysis: A case report

Girsberger

Thenganatt

Chan

2019

Hemodialysis International

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Pulmonary hypertension (PH) defined as a mean pulmonary arterial pressure ≥25 mmHg is a common complication in hemodialysis occurring in up to 58% of patients. PH is classified according to its etiology. We report in a patient with severe PH of mixed etiology (connective tissue disease and left‐sided heart failure) who improved after initiation of intensive home hemodialysis. We postulated that the use of a frequent mode of hemodialysis may ameliorate PH via enhanced volume control. Thereby, an intensive hemodialysis schedule may be preferred renal replacement modality in this patient population.

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Changes in pulmonary artery systolic pressure and right ventricular function in patients with end‐stage renal disease on maintenance dialysis

Abstract: In patients with end-stage renal disease, PASP increases over time. Changes are moderately predictable. Higher PASP predicted development of right ventricular dysfunction.

Cited by 19 publications

References 34 publications

Effects of dialysis modality choice on the survival of end-stage renal disease patients in southern China: a retrospective cohort study

Effects of dialysis modality choice on the survival of end-stage renal disease patients in southern China: a retrospective cohort study

Effects of dialysis modality choice on survival of end-stage renal disease patients in southern China: A retrospective cohort study

Correction of pulmonary hypertension with intensive hemodialysis: A case report

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