Changes in quality-of-life scores in a population of patients treated for squamous cell carcinoma of the head and neck

McDonough, Erin; Varvares, Mark A.; Dunphy, Frank; Dunleavy, Teresa L.; Dunphy, Cherie H.; Boyd, James H.

doi:10.1002/(sici)1097-0347(199611/12)18:6<487::aid-hed1>3.0.co;2-z

Cited by 50 publications

(25 citation statements)

References 19 publications

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“…However, global health status did not correlate with the kind of treatment used. These changes in quality of life can be extended to all patients with advanced head and neck cancer who undergo aggressive surgical treatments [9]. Similar perceptions have been reported elsewhere [10].…”

Section: Discussionsupporting

confidence: 83%

How much does it cost to preserve a larynx?

León

Quer

Orús

et al. 2000

European Archives of Oto-Rhino-Laryngology

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Various studies report an increase in costs when induction chemotherapy is included in the treatment of advanced laryngeal cancer, but to our knowledge no studies have yet compared the economic costs of total laryngectomy versus induction chemotherapy in the treatment of advanced laryngeal cancer. We have conducted a retrospective study comparing the costs of treatment and survival in 96 patients with a T3N0-1 glottic carcinoma. Findings showed that the average cost per patient in the group of patients treated by total laryngectomy with or without postoperative radiotherapy was 5,853 Eur, while that for the group of patients who began treatment with induction chemotherapy was 6,452 Eur. The adjusted 5-year survival for patients treated with total laryngectomy with or without postoperative radiotherapy was 80%, and 72% for patients who began treatment with induction chemotherapy. Sixteen of the 35 patients (46%) receiving induction chemotherapy were spared laryngectomy. The use of induction chemotherapy in the treatment of patients with advanced laryngeal carcinomas involved an increase in cost of 600 Eur in relation to treatment with total laryngectomy and postoperative radiotherapy. However, from an economic point of view, we consider induction chemotherapy to be an important consideration in an organ-preservation strategy.

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Section: Discussionsupporting

confidence: 83%

How much does it cost to preserve a larynx?

León

Quer

Orús

et al. 2000

European Archives of Oto-Rhino-Laryngology

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show abstract

“…Of these, 35 articles focused solely on functional outcomes related to organ preservation 1,2,14, 18-20,22,24,26-30,32-35,37,38,41,43-45,47,51,54-57, 61-64,66-68 . The remaining 15 articles reported on functional outcomes related to organ preservation as well as to primary surgery with or without chemotherapy and radiotherapy 3,5,7,9,10,16,17,21,23,48,52,58,60,65 . Because the intent of this review was to understand functional outcomes as they relate to organ preservation, details related to surgical outcomes were not reviewed.…”

Section: General Findingsmentioning

confidence: 99%

Functional outcomes after organ preservation treatment in head and neck cancer: a critical review of the literature

Rieger

Zalmanowitz

Wolfaardt

2006

International Journal of Oral and Maxillofacial Surgery

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“…Furthermore, both quality of life and clinical function after primary surgery for oral cancer seems to be better in patients who experience less invasive and disfiguring treatment (McDonough et al, 1996). Multiple oral complaints which affect quality of life mainly develop during postoperative radiation therapy.…”

Section: Article In Pressmentioning

confidence: 99%