Changes in reaction time, coefficient of variance of reaction time, and autonomic nerve function in the mental fatigue state caused by long-term computerized Kraepelin test workload in healthy volunteers

Kuratsune, Daisuke; Tajima, Seiki; Koizumi, Jun–ichi; Yamaguti, Kouzi; Sasabe, T; Mizuno, Kei; Tanaka, Masaaki; Okawa, Naoko; Mito, Hideki; Tsubone, Hirokazu; Watanabe, Yasuyoshi; Inoue, Masayasu; Kuratsune, Hirohiko

doi:10.4236/wjns.2012.22016

Cited by 16 publications

(10 citation statements)

References 16 publications

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“…However, the sympathetic nervous system was in a dominant state in these individuals, with a high LF/HF ratio, which is an indicator of the autonomic nervous system balance, exceeding the normal value of 2.0. Previous studies have shown that Uchida-Kraepelin stress affects heart rate variability [31][32][33][34]. We selected subjects who felt that taking the Uchida-Kraepelin test was stressful had a substantial increase in their LF/HF ratios.…”

Section: Discussionmentioning

confidence: 99%

Effects of Euglena gracilis Intake on Mood and Autonomic Activity under Mental Workload, and Subjective Sleep Quality: A Randomized, Double-Blind, Placebo-Controlled Trial

Nakashima¹,

Yasuda²,

Murata³

et al. 2020

Nutrients

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While the human body maintains homeostasis by altering the balance in the autonomic nervous, endocrine, and immune systems, a prolonged imbalance in these systems can result in physical and mental symptoms, including a decline in sleep quality and work efficiency. Euglena gracilis (Euglena) is a single-celled microalga with the properties of both plants and animals and contains abundant nutrients, such as vitamins, minerals, amino acids, and fatty acids, which have various beneficial health effects. This study evaluated the effects of Euglena intake on the mood states and stress coping under mental workload tasks, and subjective sleep quality. We assigned men and women aged 20 to 64 years to Euglena and placebo intake groups, and measured indices related to the autonomic nervous system, psychological states, and sleep quality together with the application of workload stress before food intake, and 4, 8, and 12 weeks after commencing intake. Euglena intake regulated the autonomic nervous system under a workload and improved psychological parameters and sleep conditions. These results indicate that the consumption of Euglena may regulate the balance of the autonomic nervous system during stress and may have a favorable effect on psychological status and sleep quality.

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Section: Discussionmentioning

confidence: 99%

Effects of Euglena gracilis Intake on Mood and Autonomic Activity under Mental Workload, and Subjective Sleep Quality: A Randomized, Double-Blind, Placebo-Controlled Trial

Nakashima¹,

Yasuda²,

Murata³

et al. 2020

Nutrients

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“…Fatigue is defined as a decline in the ability and efficiency of mental and/or physical activities [ 2 , 3 ]. In other words, maintenance of work efficiency indicates that fatigue is being suppressed [ 4 , 41 , 42 , 43 ]. There was no significant difference in the rate of correct responses in the 2-back tasks between the two groups, suggesting that the fatigue loading due to work was evenly distributed between the two groups and that EOD-1PM intake reduced fatigue due to workload.…”

Section: Discussionmentioning

confidence: 99%

Effect of Food Containing Paramylon Derived from Euglena gracilis EOD-1 on Fatigue in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial

et al. 2020

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Euglena gracilis EOD-1, a kind of microalgae, is known to contain a high proportion of paramylon, a type of β-1,3-glucan. Paramylon derived from E. gracilis EOD-1 is presumed to suppress cellular oxidative injury and expected to reduce fatigue and fatigue sensation. Therefore, we aimed to examine whether food containing paramylon derived from E. gracilis EOD-1 (EOD-1PM) ingestion reduced fatigue and fatigue sensation in healthy adults. We conducted a randomized, double-blind, placebo-controlled, parallel-group comparison study in 66 healthy men and women who ingested a placebo or EOD-1PM daily for 4 weeks (daily life fatigue). Furthermore, at the examination days of 0 and 4 weeks, tolerance to fatigue load was evaluated using mental tasks (task-induced fatigue). We evaluated fatigue sensation using the Visual Analogue Scale, the work efficiency of the advanced trail making test and measured serum antioxidant markers. The EOD-1PM group showed significantly lower levels of physical and mental fatigue sensations and higher levels of work efficiency as well as serum biological antioxidant potential levels than the placebo group. These results indicate that EOD-1PM ingestion reduced fatigue and fatigue sensation, which may be due to an increase in antioxidant potential and maintenance of selective attention during work.

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“…The results of recent studies revealing sympathetic hypertonia and reduced autonomic nervous activity among teachers in a state of chronic fatigue and workers experiencing stress imply that evaluation of autonomic nervous function may be an effective means of measuring objective fatigue. However, age greatly influences autonomic nervous activity among individuals, making it difficult to apply this method to groups with members of different ages [9, 10, 30, 31].…”

Section: Discussionmentioning

confidence: 99%

“…Sympathetic hyperactivity based on decreased parasympathetic activity has also been found to be associated with mental fatigue induced by prolonged cognitive load [8]. Furthermore, when we assessed autonomic function in a mental fatigue model of healthy volunteers caused by long-term computerized Kraepelin test workload, the low/high frequency component ratio (LF/HF) was significantly increased by the fatigue-inducing task and decreased by resting, suggesting that mental stress causes a relatively sympathetic nerve activity-dominant state [9]. When we studied autonomic nerve function in patients with chronic fatigue syndrome, we found that as the symptoms of fatigue became stronger, parasympathetic nervous activity decreased.…”

Section: Introductionmentioning

confidence: 93%

Application of autonomic nervous function evaluation to job stress screening

Okawa

Kuratsune

Koizumi

et al. 2019

Heliyon

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The present study focuses on the evaluation of autonomic nervous function, which is increasingly being used as an objective measure of fatigue state. It has recently been reported that autonomic nervous activity, which is expressed as total heart rate variability (HRV) power, is associated with, and can be used as an objective measure of, mental and physical fatigue. Total HRV power (log (LF + HF)) has been shown to decline with ageing, and thus cannot be utilized as a fatigue index in populations with a different age composition. In the present study, we devised standard scores (deviation value) for autonomic nervous activity corrected for individual age calculated from the distribution of such activity in individual age cohorts. This allowed us to accurately evaluate an individual's autonomic nervous activity, even when that individual was part of a group with members of different ages. Standard scores were quantified using autonomic nervous function data gathered from 1,969 healthy individuals (age range 20–77 years).The efficacy of this method in mental health screening was investigated by evaluating both autonomic nervous function and subjective levels of fatigue among corporate workers. Based on results from the Brief Job Stress Questionnaire recommended by the research team of the Ministry of Health, Labour and Welfare, 103 participants were divided into two groups (a high-stress group [n = 17] and a non–high-stress group [n = 86]). Visual analog scale (VAS) scores for all fatigue-related symptoms were significantly higher among the high-stress than among the non–high-stress group (p < 0.01).The mean standard score for autonomic nervous activity was 56.3 for the non–high-stress group. The score for the high-stress group was significantly lower, at 47.9 (p < 0.01), indicating that autonomic nervous function was reduced among participants who experienced high stress. According to an analysis of raw and standard scores in each domain, autonomic nervous activity did not significantly correlate with stress-causing factors (e.g., overwork) or other factors affecting stress responses (e.g., support from supervisors and colleagues), but did exhibit a significant positive correlation with physical and mental responses to stress (r = 0.334, p < 0.01). Lower raw scores for mental and physical responses to stress represent stronger subjective symptoms. Moreover, greater stress responses were found to be associated with lower standard scores for autonomic nervous activity.In terms of fatigue-related symptoms rated using the VAS, autonomic nervous activity negatively correlated with mental stress, physical stress, fatigue/malaise, depressed mood, anxiety/fear, tension, irritation/anger, cognitive decline, and muscle/joint/general pain, and positively correlated with motivation/vitality. Reduced autonomic nervous activity was observed with high stress, confirming that standard scores for autonomic nervous activity are associated with mental and physical responses to stress and subjective fatigue-related symptoms.These res...

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Changes in reaction time, coefficient of variance of reaction time, and autonomic nerve function in the mental fatigue state caused by long-term computerized Kraepelin test workload in healthy volunteers

Cited by 16 publications

References 16 publications

Effects of Euglena gracilis Intake on Mood and Autonomic Activity under Mental Workload, and Subjective Sleep Quality: A Randomized, Double-Blind, Placebo-Controlled Trial

Effects of Euglena gracilis Intake on Mood and Autonomic Activity under Mental Workload, and Subjective Sleep Quality: A Randomized, Double-Blind, Placebo-Controlled Trial

Effect of Food Containing Paramylon Derived from Euglena gracilis EOD-1 on Fatigue in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial

Application of autonomic nervous function evaluation to job stress screening

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