Changes in renal function and morphological variations of kidney diseases in rheumatoid arthritis patients

Yan, Tao; Varavko, Yuliya; Aringazina, Raisa; Menshikova, I. A.

doi:10.1016/j.ajur.2022.06.005

Cited by 4 publications

(4 citation statements)

References 33 publications

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“…RA being a systemic disorder can also affect kidney adversely (44). Creatinine and uric acid are wellknown markers of glomerular ltration rate (GFR).…”

Section: Discussionmentioning

confidence: 99%

“…Creatinine and uric acid are wellknown markers of glomerular ltration rate (GFR). Elevated creatinine and uric acid levels could be due to lowered capacity of nephrons culminating in a decrease in the kidney's ltering capacity and subsequent accumulation of waste products within the system (44). In this study, some of the biochemical markers of the liver (ALT, AST, ALP, total protein, albumin, total and conjugated bilirubin), hematological (Hb, PCV, RBC, WBC, and ESR) and renal (creatinine and uric acid) functions were investigated.…”

Section: Discussionmentioning

confidence: 99%

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Ethanol Leaf Extract of Buchholzia coriacea Ameliorates Biochemical Dysregulations Due to Rheumatoid Arthritis in Wistar Albino Rats

Alum,

Krishnamoorthy,

Gatasheh

et al. 2024

Preprint

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Background Rheumatoid arthritis (RA) is a disease that involves many body organs. In this study, we examined the anti-rheumatoid arthritis effect of ethanol leaf extract of Buchholzia coriacea (ELEBC). Methods Firstly, the chemical compositions of ELEBC were investigated. The in vivo study was further done using 90 female rats weighing 121–146 g. Rats were appropriated into 6 groups (n = 15). Group 1 was provided with normal saline (1 ml/kg) only. Group 2 was induced with RA and untreated. Group 3 was induced and treated with 5 mg/kg indomethacin™ while Groups 4–6 were induced with RA and treated with ELEBC at varied doses of 200, 400, and 800 mg/kg body weight, respectively. Induction of RA was done using Freund’s adjuvant, whereas the route of administration of the standard drug and the extract was via oral intubation. The study period was 31 days. Results The chemical composition analysis revealed that ELEBC has a high level of various chemical constituents. The adjuvant injection caused a significant increase in paw sizes plus a reduction in body weight. Levels of creatinine, uric acid, total protein, white blood cell, and total and conjugated bilirubin were significantly elevated in the arthritic rats. There were significant elevations in alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase activities while the levels of red blood cells, packed cell volume, and hemoglobin were lowered significantly. Treatment with ELEBC markedly reduced the paw sizes and caused weight gain. Conclusion Other biochemical dysregulations were also ameliorated. Thus, ELEBC may be useful in the control of RA.

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“…RA being a systemic disorder can also affect kidney adversely (44). Creatinine and uric acid are wellknown markers of glomerular ltration rate (GFR).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Ethanol Leaf Extract of Buchholzia coriacea Ameliorates Biochemical Dysregulations Due to Rheumatoid Arthritis in Wistar Albino Rats

Alum,

Krishnamoorthy,

Gatasheh

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…In the population-based cohort of patients with RA from Olmsted County, Minnesota, USA, ExRA features of glomerulonephritis and amyloidosis have been extinct in the past two decades, owing to early use of effective immunosuppressive regimens [2 ▪▪ ]. However, studies from other centers continue to report renal ExRA manifestations in patients with active RA, with mesangial proliferative glomerulonephritis and renal amyloidosis as most prevalent morphological abnormalities on kidney biopsy [49].…”

Section: Introductionmentioning

confidence: 99%

Updates on interstitial lung disease and other selected extra-articular manifestations of rheumatoid arthritis

Myasoedova,

Matteson

2024

Current Opinion in Rheumatology

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Purpose of review To discuss changes in epidemiology, recent advances in understanding of the pathogenesis and management of selected extraarticular manifestations of rheumatoid arthritis (ExRA). Recent findings The incidence of ExRA overall and subcutaneous rheumatoid nodules in particular is declining after 2000. These trends reflect improved RA disease activity with early effective immunosuppressive treatments; changing environmental risk factors can be contributing. ExRA continues to carry a two-fold increased mortality risk. RA-associated interstitial lung disease (RA-ILD) is a major contributor to mortality, with no decline in incidence and scant therapeutic options. Individualized risk stratification for RA-ILD based on patient-level risk factors and biomarker profile is evolving with MUC5B as a major genetic risk factor. Clinical trials are underway to evaluate the benefits of novel antifibrotic therapies and targeted therapies for RA-ILD. The risk of cardiovascular disease in RA is generally amendable to treatment with disease-modifying antirheumatic drugs, although cardiovascular risk associated with JAK inhibition is not fully understood. Summary Despite reduction in incidence of ExRA overall, the incidence of RA-ILD shows no significant decline and remains a major therapeutic challenge. The use of novel antifibrotics and immunosuppressive drugs shows promise in slowing the progression of RA-ILD.

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“…13 According to different studies high levels of urea, uric acid and creatinine in arthritis patients may viewed as inflammatory markerfor severity of joint inflammation and sign of renal dysfunction. 14,15 Prevalence of types of arthritis and its association with biochemical parameters among pre-and post-menopausal women in different cities of Pakistan.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of types of arthritis and its association with biochemical parameters among pre- and post-menopausal women in different cities of Pakistan.

Qamar Yasmeen,

Summaira Yasmeen

2023

j Muhammad Med Coll

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Introduction: The prevalence of arthritis among both pre and post menopausal is alarmingly high. Old age, gender, obesity, unhealthy life style, poor nutrition, less physical activity, genetics, lack of knowledge about disease, lack if education are the factors which are strongly associated with onset of arthritis. Objective: To document prevalence of different types of arthritis and its association with biochemical parameters among pre- and post-menopausal women in different cities of Pakistan. Methodology: A total of 300 females’ patients who were diagnosed as case of arthritis from different aetiology, during April 2022 to September 2022, aged above 40 years were enrolled for this cross-sectional observational questionnaire and laboratory-based study. Their demographic and disease-related biochemical parameters were recorded and analysed. Results: Over all prevalence of rheumatoid arthritis was high (39%) among both pre- and post-menopausal females. Biochemical laboratory analysis showed mean low (11.90 ± 2.18) level of haemoglobin. 66.6% and 60.6 % of the female patients were seropositive for Rheumatoid factor (RF) and Anti Cyclic Citrullinated Protein (Anti-CCP) which is clinical characteristics of Arthritis patients. Conclusion: Women with different type of arthritis have border line mean levels of biochemical parameters which indicate co-morbidities like diabetes, cardiovascular and renal diseases, hypertension, obesity and osteoporosis. Keywords: Post-menopausal, rheumatoid, psoriatic, osteoarthritis, biochemical parameters.

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Changes in renal function and morphological variations of kidney diseases in rheumatoid arthritis patients

Cited by 4 publications

References 33 publications

Ethanol Leaf Extract of Buchholzia coriacea Ameliorates Biochemical Dysregulations Due to Rheumatoid Arthritis in Wistar Albino Rats

Ethanol Leaf Extract of Buchholzia coriacea Ameliorates Biochemical Dysregulations Due to Rheumatoid Arthritis in Wistar Albino Rats

Updates on interstitial lung disease and other selected extra-articular manifestations of rheumatoid arthritis

Prevalence of types of arthritis and its association with biochemical parameters among pre- and post-menopausal women in different cities of Pakistan.

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