The field of pathology, which provides tissue diagnoses for clinical and research purposes, is at the heart of medical decision-making. The current move to digital pathology (DP) is a fundamental change in how primary diagnostic work, consultations, education, and multidisciplinary conferences are performed. DP is the prerequisite for computational pathology (CPATH), the big-data approach to pathology that extracts information from images, typically using artificial intelligence (AI) methods. While CPATH offers significant new capabilities and workflows, it also brings new challenges. There will be knock-on effects on other specialties and in teaching and research. The emerging next-generation pathology will be more quantitative, will have more diagnostic consistency, and will be more connected to its medical peers.