Changes in Retinal Microcirculation After Intravitreal Ranibizumab Injection in Eyes With Macular Edema Secondary to Branch Retinal Vein Occlusion

Fukami, Marie; Iwase, Takeshi; Yamamoto, Kentaro; Kaneko, Hiroki; Yasuda, Shunsuke; Terasaki, Hiroko

doi:10.1167/iovs.16-21115

Cited by 37 publications

(34 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While some reports demonstrate adverse vasoconstrictive effects on retinal perfusion that include a reduction in retinal vessel diameters and flow velocities, [31][32][33][34] there are others that demonstrate positive effects of anti-VEGF therapy on retinal perfusion, such as prevention of retinal nonperfusion. 35,36 In the current study, quantitative OCTA imaging identified that both VD and FAZ within the 3 3 3-mm area did not differ significantly during the course of anti-VEGF therapy for 12 months in patients with RVO.…”

Section: Discussionmentioning

confidence: 99%

Changes in Retinal Microvasculature and Visual Acuity After Antivascular Endothelial Growth Factor Therapy in Retinal Vein Occlusion

Winegarner

Wakabayashi

Fukushima

et al. 2018

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

PURPOSE. To investigate the changes in the retinal microvasculature during the course of anti-VEGF therapy in eyes with macular edema due to retinal vein occlusion (RVO) and their association with visual outcomes.METHODS. The vessel density (VD) and foveal avascular zone (FAZ) area in the superficial capillary plexus (SCP) and deep capillary plexus (DCP) were quantitatively measured by optical coherence tomography angiography (OCTA) in 48 consecutive eyes with RVO before and 1, 3, 6, 9, and 12 months after anti-VEGF therapy. Anti-VEGF therapy was performed either with ranibizumab or aflibercept following a pro re nata (PRN) regimen. The correlation between post-treatment best-corrected visual acuity (BCVA) and changes in the retinal microvasculature evaluated by OCTA were assessed.RESULTS. The BCVA improved significantly at 12 months (P < 0.001). Better BCVA at 12 months was significantly associated with a better VD in the SCP and DCP both at baseline (R 2 ¼ 0.524, P < 0.001 and R 2 ¼ 0.457, P < 0.001, respectively) and at 12 months (R 2 ¼ 0.521, P < 0.001 and R 2 ¼ 0.662, P < 0.001, respectively). Overall, both VD and FAZ did not change significantly during the 12 months. However, the progression of nonperfusion was observed in the SCP in 6 (13%) eyes and in the DCP in 10 (21%) eyes. The number of macular edema recurrence was significantly associated with a decrease in the VD (P ¼ 0.006 [SCP] and P < 0.001 [DCP]) and less visual gain (P ¼ 0.02) after treatment.CONCLUSIONS. Anti-VEGF therapy maintains retinal perfusion in most patients with RVO. Preserving retinal perfusion is crucial for better visual outcomes.

show abstract

Section: Discussionmentioning

confidence: 99%

Changes in Retinal Microvasculature and Visual Acuity After Antivascular Endothelial Growth Factor Therapy in Retinal Vein Occlusion

Winegarner

Wakabayashi

Fukushima

et al. 2018

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

“…Fukami et al [12] studied the effects of IVR injection in eyes affected by ME in branch RVO and found that IVR injection leads to a transient vasoconstriction of the retinal arteries and veins and a reduction of the retinal blood flow and velocity in both occluded and not occluded quadrants.…”

Section: Discussionmentioning

confidence: 99%

“…In detail, LSFG (Softcare, Fukutsu, Japan) is a fundus camera equipped with a diode laser (wavelength, 830 nm) and a charge-coupled device sensor (750 × 360 pixels), which are used to obtain images of the pattern of speckle contrast produced by interference as laser light is scattered by red blood cells moving through vessels in the ocular fundus. Light reflected from the tissue produces a speckled pattern on the plane where the area sensor is focused and reflected light from moving erythrocytes causes blurring of the speckle pattern [12]. e same site can be measured by using the autotracking system.…”

Section: Laser Speckle Flowgraphy Assessmentmentioning

confidence: 99%

“…MBR represents the velocity of the blurring in the speckle pattern that is caused by blood flow [10]. Images are acquired continuously at the rate of 30 frames/sec over a 4 sec period and then averaged to produce a composite map of ocular blood flow [12]. e analysis of ONH offers additional capabilities to analyze data within the rubber band.…”

Section: Laser Speckle Flowgraphy Assessmentmentioning

confidence: 99%

See 1 more Smart Citation

Changes in Ocular Blood Flow after Ranibizumab Intravitreal Injection for Diabetic Macular Edema Measured Using Laser Speckle Flowgraphy

Toto

Evangelista

Viggiano

et al. 2020

BioMed Research International

View full text Add to dashboard Cite

Purpose. To evaluate the effects of intravitreal ranibizumab (IVR) treatment on the blood flow of the optic nerve head (ONH) and of retinal vessels of the peripapillary region of eyes with diabetic macular edema (DME) assessed using laser speckle flowgraphy (LSFG). Methods. Forty eyes of 30 patients treated with IVR for DME were included in this prospective clinical study. Mean blur rate (MBR) and relative flow volume (RFV) of the ONH and of a superior retinal artery and an inferior retinal vein of the peripapillary region were measured using LSFG at baseline, 2 weeks (T1), and 1 month (T2) after IVR injection. In addition, best-corrected visual acuity (BCVA) and central retinal thickness (CRT) were measured in all cases. Results. The BCVA improved and CRT decreased significantly during the follow-up period (p<0.010). MBR-related parameters of the ONH such as MBR of all area (MA), MBR of vascular area (MV), and MBR of tissue area (MT) decreased significantly at 2 weeks after IVR compared to baseline values (MA, p=0.046; MT, p=0.023; MV, p=0.025), with no significant change at T2 compared to T1. MBR of the retinal artery and vein changed significantly at 2 weeks after IVR and did not change significantly thereafter (p=0.004 and p=0.01, respectively). The median of RFV of the 2 vessels was 269.5 (221.6–285.5) and 306.8 (285.6–372.4) at baseline and 199.7 (152.4–204.7) and 259.1 (140.9–336.8) at 4 weeks, respectively (p=0.292 and p=0.002, respectively). Blowout time changed significantly in ONH from 47.6 (44.2–50.2) at baseline to 54.4 (46.8–65.3) at 1 month after IVR (p=0.001). Conclusion. IVR injection leads to a reduction of ocular blood flow both in the ONH and in the retinal peripapillary vessels associated with peripapillary vessel constriction. The reduction of CRT and related improvement of vision may be related to the changes in ocular blood flow.

show abstract

“…During anti-VEGF treatment, RNFL edema remitts with the resolution of BRVO. Moreover, anti-VEGF treatment significantly reduces peripapillary blood flow volume and vessel diameter (17). These changes bring pRNFL thickness to "normal" levels in general.…”

mentioning

confidence: 93%

Branch Retinal Vein Occlusion Causes Topographic Optic Neuropathy and Retrograde Maculopathy

Abegg

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

Changes in Retinal Microcirculation After Intravitreal Ranibizumab Injection in Eyes With Macular Edema Secondary to Branch Retinal Vein Occlusion

Cited by 37 publications

References 54 publications

Changes in Retinal Microvasculature and Visual Acuity After Antivascular Endothelial Growth Factor Therapy in Retinal Vein Occlusion

Changes in Retinal Microvasculature and Visual Acuity After Antivascular Endothelial Growth Factor Therapy in Retinal Vein Occlusion

Changes in Ocular Blood Flow after Ranibizumab Intravitreal Injection for Diabetic Macular Edema Measured Using Laser Speckle Flowgraphy

Branch Retinal Vein Occlusion Causes Topographic Optic Neuropathy and Retrograde Maculopathy

Contact Info

Product

Resources

About