Changes in routine blood parameters of patients with generalized tonic clonic seizure: a retrospective study

Huang, Jiankang; Yang, Jun; Miao, Jiali; Wen, Hongbo

doi:10.17712/nsj.2023.2.20220135

NSJ

2023

DOI: 10.17712/nsj.2023.2.20220135

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Changes in routine blood parameters of patients with generalized tonic clonic seizure: a retrospective study

Jiankang Huang

Jun Yang

Jiali Miao

et al.

Abstract: E pilepsy is a relatively common neurological disorder which is characterized by persistent susceptibility to seizures and the associated cognitive and psychosocial consequences. 1 Epilepsy is among the top 3 most contributing diseases to the global burden in terms of 124 Blood parameters change of GTCS patients ... Huang et al

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2024

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Cited by 1 publication

References 30 publications

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Predictive value of neutrophil to lymphocyte ratio (NLR) for epileptic seizures: a systematic review and meta- analysis

Li,

Wei,

Aihemaitiniyazi

et al. 2024

Preprint

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The neutrophil-to-lymphocyte ratio (NLR) is a commonly used biomarker for inflammation and is typically elevated in patients experiencing epileptic seizures making it a valuable diagnostic indicator in clinical practice. However, there is no consensus on the predictive value of NLR in patients with epileptic seizures. Given this controversy, we conducted a meta-analysis to clarify the predictive value of NLR for epileptic seizures. We conducted a comprehensive literature search in the PubMed, Embase, Cochrane Library, and Web of Science databases, systematically reviewing the literature from January 1, 2000, to May 1, 2024, and determined the eligible studies. NLR values and corresponding sample sizes were extracted from each included study, and a random effects model was used for the meta-analysis. Sensitivity analysis was performed to investigate heterogeneity. Subgroup analysis was conducted to explore the sources of heterogeneity. Egger's test was also used in this meta-analysis to investigate publication bias. After a comprehensive literature search and screening, we included 16 studies in our meta-analysis. The pooled results indicate that NLR levels in the epileptic seizure group are significantly higher compared to the non-seizure group (random effects model, SMD 0.49, 95% CI: 0.31, 0.67, P < 0.0001). Heterogeneity tests revealed significant heterogeneity (I² = 82%). Sensitivity analysis results indicate that our findings are robust to the influence of individual studies. Subgroup analysis results suggest that the testing time of NLR and mean/median age are sources of heterogeneity. Egger's test shows no significant publication bias in this meta-analysis. This is the first meta-analysis to demonstrate that NLR, as a biomarker, has good predictive value for epileptic seizures. The meta-analysis has been registered in the PROSPERO database (registration number CRD42024550918).

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Predictive value of neutrophil to lymphocyte ratio (NLR) for epileptic seizures: a systematic review and meta- analysis

Li,

Wei,

Aihemaitiniyazi

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

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Changes in routine blood parameters of patients with generalized tonic clonic seizure: a retrospective study

Cited by 1 publication

References 30 publications

Predictive value of neutrophil to lymphocyte ratio (NLR) for epileptic seizures: a systematic review and meta- analysis

Predictive value of neutrophil to lymphocyte ratio (NLR) for epileptic seizures: a systematic review and meta- analysis

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