Changes in saccadic eye movement (SEM) and quantitative EEG parameter in bipolar patients

Velasques, Bruna; Bittencourt, Juliana; Diniz, Claudia; Teixeira, Silmar; Basile, Luis; Salles, José Inácio; Novis, Fernanda; Silveira, Luciana Angélica Silva; Silva, Rafael de Assis da; Teixeira, Amanda de Lima; Nardi, Antônio Egídio; Akiskal, Hagop S.; Cagy, Maurício; Piedade, Roberto; Cheniaux, Elie; Kapczinki, Flávio; Ribeiro, Pedro

doi:10.1016/j.jad.2012.04.049

Cited by 23 publications

(14 citation statements)

References 35 publications

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“…However, the absolute alpha power was greater in pre moment when compared with post moment. The behavioral data already published elsewhere [17].…”

Section: Resultsmentioning

confidence: 99%

Electrocortical Activity Differences Related to Saccadic Movements between Bipolar Patients and Healthy Subjects

Batista¹,

Bittencourt²,

Salles³

et al. 2013

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Objective: The present study aimed to investigate and to compare the electrophysiological changes in bipolar patients and healthy subjects during the execution of a saccade task. Materials and Methods: The subjects had to respond to a fixed visual stimulus presented by a LEDs bar. We executed an ANOVA (one-way) and post hoc Scheffé test to examine the difference of absolute alpha power and reaction time among four groups: control, depression, manic and euthymic. We observed the frontal, parietal and occipital regions. The paired t test was realized on each electrode and group to compare the pre and post moment in the task. Results: We observed a statistical difference among the groups for the behavioral variable—saccade reaction time. For the electrophysiological variable —absolute alpha power, we did not find significant difference between the moments (pre and post stimulus presentation) for none of the electrodes of each bipolar group. However, the results pointed out to a difference between the moments for F3, P3, O1 and O2 electrodes for control group. Conclusion: We cannot affirm that the task influences the cortical activity of the patients. It is possible that the method used to analyze the data is not the adequate. The time-frequency analysis could be better to analyze the present data. We also observed that the absolute alpha power could be considered a marker of bipolar disorder, but not of the different states (i.e., mania, depression, euthymia).

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“…However, the absolute alpha power was greater in pre moment when compared with post moment. The behavioral data already published elsewhere [17].…”

Section: Resultsmentioning

confidence: 99%

Electrocortical Activity Differences Related to Saccadic Movements between Bipolar Patients and Healthy Subjects

Batista¹,

Bittencourt²,

Salles³

et al. 2013

Self Cite

View full text Add to dashboard Cite

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“…For example, Nakatani et al 154 revealed that, in a perceptual task, the alpha band amplitude from occipital regions predicted blinks and saccade effects. Moreover, Velasques et al 155 showed that, during a prosaccadic attention task, the saccade amplitude was associated with frontal gamma changes. Furthermore, Bodala et al 156 found that decreases in frontal midline theta were accompanied by decreases in sustained attention, as well as the amplitude and velocity of saccades.…”

Section: Discussionmentioning

confidence: 99%

A Visuospatial Planning Task Coupled with Eye-Tracker and Electroencephalogram Systems

Domic-Siede

Irani

Valdés

et al. 2023

JoVE

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The planning process, characterized by the capability to formulate an organized plan to reach a goal, is essential for human goal-directed behavior. Since planning is compromised in several neuropsychiatric disorders, the implementation of proper clinical and experimental tests to examine planning is critical. Due to the nature of the deployment of planning, in which several cognitive domains participate, the assessment of planning and the design of behavioral paradigms coupled with neuroimaging methods are current challenges in cognitive neuroscience. A planning task was evaluated in combination with an electroencephalogram (EEG) system and eye movement recordings in 27 healthy adult participants. Planning can be separated into two stages: a mental planning stage in which a sequence of steps is internally represented and an execution stage in which motor action is used to achieve a previously planned goal. Our protocol included a planning task and a control task.The planning task involved solving 36 maze trials, each representing a zoo map. The task had four periods: i) planning, where the subjects were instructed to plan a path to visit the locations of four animals according to a set of rules; ii) maintenance, where the subjects had to retain the planned path in their working memory; iii) execution, where the subjects used eye movements to trace the previously planned path as indicated by the eye-tracker system; and iv) response, where the subjects reported the order of the visited animals. The control task had a similar structure, but the cognitive planning component was removed by modifying the task goal. The spatial and temporal patterns of the EEG revealed that planning induces a gradual and lasting rise in frontal-midline theta activity (FMθ) over time. The source of this activity was identified within the prefrontal cortex by source analyses. Our results suggested that

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“…The SC is critical for express triggering (Schiller and Tehovnik, 2005 ), where a switch enables visual neurons to directly activate motor neurons (Isa and Kobayashi, 2004 ). Taken together, these studies explain how express eye movements can be biomarkers of control loss observed in psychiatric disorders such as schizophrenia (Currie et al, 1993 ) or bipolar disorder (Velasques et al, 2013 ).…”

Section: An Integrative Model For the Neural Mechanism Of Emdrmentioning

confidence: 91%

An Integrative Model for the Neural Mechanism of Eye Movement Desensitization and Reprocessing (EMDR)

Coubard¹

2016

Front. Behav. Neurosci.

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Since the seminal report by Shapiro that bilateral stimulation induces cognitive and emotional changes, 26 years of basic and clinical research have examined the effects of Eye Movement Desensitization and Reprocessing (EMDR) in anxiety disorders, particularly in post-traumatic stress disorder (PTSD). The present article aims at better understanding EMDR neural mechanism. I first review procedural aspects of EMDR protocol and theoretical hypothesis about EMDR effects, and develop the reasons why the scientific community is still divided about EMDR. I then slide from psychology to physiology describing eye movements/emotion interaction from the physiological viewpoint, and introduce theoretical and technical tools used in movement research to re-examine EMDR neural mechanism. Using a recent physiological model for the neuropsychological architecture of motor and cognitive control, the Threshold Interval Modulation with Early Release-Rate of rIse Deviation with Early Release (TIMER-RIDER)—model, I explore how attentional control and bilateral stimulation may participate to EMDR effects. These effects may be obtained by two processes acting in parallel: (i) activity level enhancement of attentional control component; and (ii) bilateral stimulation in any sensorimotor modality, both resulting in lower inhibition enabling dysfunctional information to be processed and anxiety to be reduced. The TIMER-RIDER model offers quantitative predictions about EMDR effects for future research about its underlying physiological mechanisms.

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Changes in saccadic eye movement (SEM) and quantitative EEG parameter in bipolar patients

Cited by 23 publications

References 35 publications

Electrocortical Activity Differences Related to Saccadic Movements between Bipolar Patients and Healthy Subjects

Electrocortical Activity Differences Related to Saccadic Movements between Bipolar Patients and Healthy Subjects

A Visuospatial Planning Task Coupled with Eye-Tracker and Electroencephalogram Systems

An Integrative Model for the Neural Mechanism of Eye Movement Desensitization and Reprocessing (EMDR)

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