Changes in Serum and Urinary Zinc Induced by Asa and Indomethacin

Ambanelli, U

doi:10.3109/03009748209098118

Cited by 16 publications

(4 citation statements)

References 8 publications

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“…There were no histopathologic changes in other samples. The decreased renal toxicity may be caused by the protective effect of increased urinary excretion of zinc formed by aspirin [10]. Similar with the slight changes in histopathology, the liver SOD, GSH-Px, and MDA levels were also slightly affected.…”

Section: Discussionsupporting

confidence: 62%

“…The mechanism how aspirin impairs the antioxidant system is not clear, but it may be by way of decreasing the serum levels of the trace elements (selenium, zinc, etc.) functioning as cofactors of antioxidant enzymes [7,10,11]. Another observation supporting this hypothesis is the increase in the antioxidant enzyme levels with trace element supplementation during long-term treatment [12].…”

Section: Introductionmentioning

confidence: 79%

“…Zinc and Se are cofactors of SOD and GSH-Px, respectively, and essential elements to be bound for activity. Aspirin is found to decrease the serum levels and increase the urinary excretion of zinc [10,12]. The enzyme activity of GSH-Px is limited by Se availability and decreased under a critical level of Se [7].…”

Section: Discussionmentioning

confidence: 98%

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Do Zinc and Selenium Prevent the Antioxidant, Hepatic and Renal System Impairment Caused by Aspirin in Rats?

Kesik

Lenk

Kürekçi

et al. 2008

Biol Trace Elem Res

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Aspirin is widely used as an antiinflammatory drug especially in children with rheumatic fever arthritis. The diminishing effects of aspirin on antioxidant enzymes and hepato-renal systems at high doses are well-known. It is now evident that the damage at antioxidant system worsens the clinical picture of the disease and prolongs the treatment time. Thus, we investigated the effect of antioxidant enzyme cofactors-zinc and selenium-supplementation on superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and malondialdehyde (MDA) levels (erythrocyte and liver) and hepato-renal toxicity during aspirin treatment at therapeutic doses. The rats were divided into five groups. The first and second groups were given aspirin 75 mg/kg/day and aspirin plus selenium (Selenium 200, selenium 200 mg tablet as selenium yeast, GNC) and zinc (Zinc 100, zinc 100 mg tablet as zinc gluconate, GNC), respectively, the third and fourth take 50 mg/kg/day aspirin and aspirin plus selenium and zinc twice a day, respectively. The fifth group was control. The rats were treated with aspirin for 5 weeks as in the treatment of rheumatic fever arthritis in children. Erythrocyte SOD and MDA levels were preserved with supplementation, whereas there was no change for GSH-Px levels. Liver SOD, GSH-Px, and MDA levels were not changed. In zinc- and selenium-supplemented groups, the levels of serum alanine aminotransferase, uric acid, and direct bilirubin levels were found statistically decreased compared with nonsupplemented groups. There was no significant histopathologic change in specimens of hepatic and renal tissues. Trace element supplementation may prevent free radical damage and shorten treatment time in children using long-term aspirin treatment.

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Section: Discussionsupporting

confidence: 62%

Section: Introductionmentioning

confidence: 79%

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Do Zinc and Selenium Prevent the Antioxidant, Hepatic and Renal System Impairment Caused by Aspirin in Rats?

Kesik

Lenk

Kürekçi

et al. 2008

Biol Trace Elem Res

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“…the two important findings were: 1) the low serum zinc levels found in RA patients did not correlate with the investigated parameters and therefore seem not to reflect the degree of disease activity; 2) zinc levels correlated with the duration of disease and to a lesser degree with steroid treatment, which coupled with the lack of concomitant hypercupremia could imply the existence of other factors responsible for both (3). It should be stressed that our findings do not permit any conclusion on the therapeutic value of zinc administration in RA (4).…”

Section: Serum Zinc and Copper Levels In Rheumatoid Arthritismentioning

confidence: 97%