Changes in Serum Apolipoprotein and Lipoprotein Profile After Alcohol Withdrawal: Effect of Apolipoprotein E Polymorphism

Guéguen, Sonia; Herbeth, Bernard; Pirollet, P.; Paille, F.; Siest, Gérard; Visvikis, Sophie

doi:10.1111/j.1530-0277.2002.tb02567.x

Cited by 6 publications

(3 citation statements)

References 44 publications

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“…Therefore hypertriglyceridemia by any cause appears to be a risk factor for the onset and progression of hepatic damage. Our study shows an association between hypertriglyceridemia and the onset of alcoholic cirrhosis, as well as a contribution of triglycerides by themselves in the early onset of the disease and confirms the interaction of APOE polymorphism and alcohol as reported by Gueguen et al. (2002).…”

Section: Discussionsupporting

confidence: 91%

Association of the ε2 Allele of Apoe Gene to Hypertriglyceridemia and to Early‐Onset Alcoholic Cirrhosis

Hernández‐Nazará¹,

Ruíz-Madrigal²,

Martínez-López

et al. 2008

Alcoholism Clin & Exp Res

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Section: Discussionsupporting

confidence: 91%

Association of the ε2 Allele of Apoe Gene to Hypertriglyceridemia and to Early‐Onset Alcoholic Cirrhosis

Hernández‐Nazará¹,

Ruíz-Madrigal²,

Martínez-López

et al. 2008

Alcoholism Clin & Exp Res

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“…The higher apo B levels among ɛ4 carriers have been described previously (30), as have the effects of the ɛ polymorphism and alcohol consumption on apo B levels (38). In this study, a significant interaction between alcohol consumption and apo E alleles was found; apo B levels increased considerably as a function of alcohol consumption in ɛ2 but not in ɛ4 carriers, whereas the increase of apo B levels in ɛ3 carriers was relatively modest.…”

Section: Discussionmentioning

confidence: 53%

Obesity and Alcohol Modulate the Effect of Apolipoprotein E Polymorphism on Lipids and Insulin

et al. 2003

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MARQUES-VIDAL, PEDRO, VANINA BONGARD, JEAN-BERNARD RUIDAVETS, JOSETTE FAUVEL, HÉ LÈ NE HANAIRE-BROUTIN, BERTRAND PERRET, AND JEAN FERRIÈ RES. Obesity and alcohol modulate the effect of apolipoprotein E polymorphism on lipids and insulin. Obes Res. 2003;11:1200 -1206. Objective: To assess the interaction between apolipoprotein (apo) E polymorphism, alcohol consumption, and BMI on insulin, lipid, and lipoprotein levels in men. Research Methods and Procedures:Cross-sectional study of 266 healthy men without hypolipidemic or antidiabetic drug treatment. BMI, apo E polymorphisms, insulin, and lipid and lipoprotein levels were assessed. Alcohol consumption was assessed by questionnaire. 2/4 carriers were excluded from the analysis. Results: On bivariate analysis, 2 carriers had lower levels of total and low-density lipoprotein cholesterol and higher levels of apo E and lipoparticle B:E than 3 carriers, the opposite being found for 4 carriers compared with 3 carriers; 4 carriers also had significantly higher insulin levels. On multivariate analysis, significant interactions (p Ͻ 0.04) between apo E alleles and increased BMI were found for total and low-density lipoprotein cholesterol and insulin levels, the increase in those parameters with BMI being stronger among 4 carriers than among 3 or 2 carriers. Significant interactions (p Ͻ 0.02) between apo E alleles and alcohol consumption were also found for apo B levels, which increased in 2 carriers but remained relatively stable in 3 and tended to decrease in 4 carriers. Discussion: These data suggest that effects of apo E alleles on lipids and insulin levels are partly dependent on environmental variables such as BMI and alcohol intake. These findings highlight the importance of gene ϫ environment interactions on the deleterious effect of obesity on cardiovascular risk factors.

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“…An explanation for this may be that we could obtain only recent self‐reported alcohol consumption data while the suicide attempt in some cases dated back years. Alcohol withdrawal has been proposed as a factor potentially increasing the risk for suicide (Bradvik and Berglund, 2003) and may have an influence on serum lipids although respective reports are equivocal (Huang et al, 1992; Gueguen et al, 2002). In our study, no withdrawal symptoms scale was applied.…”

Section: Discussionmentioning

confidence: 99%

Serum Lipids and Risk Factors for Attempted Suicide in Patients with Alcohol Dependence

Deisenhammer

Lechner‐Schoner

Kemmler

et al. 2006

Alcoholism Clin & Exp Res

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Changes in Serum Apolipoprotein and Lipoprotein Profile After Alcohol Withdrawal: Effect of Apolipoprotein E Polymorphism

Cited by 6 publications

References 44 publications

Association of the ε2 Allele of Apoe Gene to Hypertriglyceridemia and to Early‐Onset Alcoholic Cirrhosis

Association of the ε2 Allele of Apoe Gene to Hypertriglyceridemia and to Early‐Onset Alcoholic Cirrhosis

Obesity and Alcohol Modulate the Effect of Apolipoprotein E Polymorphism on Lipids and Insulin

Serum Lipids and Risk Factors for Attempted Suicide in Patients with Alcohol Dependence

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