Changes in serum desnutrin levels in patients with acne vulgaris

Demir, Betül; Uçak, Haydar; Çiçek, Demet; Aydın, Süleyman; Erden, Ilker; Dertlioğlu, Selma Bakar

doi:10.1684/ejd.2014.2405

Cited by 14 publications

(17 citation statements)

References 25 publications

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“…The level of serum desnutrin was significantly lower in cases than in controls. This result is aligned with that of the study done by Demir et al (9) , on 25 patients presenting with acne vulgaris and 25 control subjects.…”

Section: Discussionsupporting

confidence: 92%

“…There also was a significantly higher level of fasting blood glucose among cases than controls which was also in harmony with those found by Demir et al (9) . There was also a negative correlation between fasting blood glucose level and serum desnutrin level which also is aligned with the study done by Demir et al (9) . In addition, Demir et al (9) , found that patients also had insulin levels and HOMA-IR values significantly higher than the control group.…”

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 85%

“…In the study done by Demir et al (9) , patients with acne vulgaris also had a mean serum desnutrin level significantly lower compared to that of control group. There also was a significantly higher level of fasting blood glucose among cases than controls which was also in harmony with those found by Demir et al (9) . There was also a negative correlation between fasting blood glucose level and serum desnutrin level which also is aligned with the study done by Demir et al (9) .…”

Section: Discussionmentioning

confidence: 85%

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Assessment of Serum Desnutrin Levels in Patients with Acne Vulgaris

Saleha

Shararab

Habib

2017

EJHM

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Background: Acne vulgaris is a common chronic skin disease involving blockage and/or inflammation of pilosebaceous units (hair follicles and their accompanying sebaceous gland). Desnutrin is the major triglyceride lipase in the adipose tissue of mice and excessive secretion from adipocytes results in decreased triacylglycerol storage and increased lipolysis, fatty acid oxidation and thermogenesis. Objective: The aim of this study is to evaluate serum level of Desnutrin in acne vulgaris patients and correlate it with disease severity. Patients and Methods: This study was performed on 40 patients with active acne lesions and 40 healthy subjects with no previous history of acne and no active acne lesions as controls. The control group was composed of age, gender, and Body mass index (BMI) matched individuals. All the patients were recruited from the outpatient clinic of Dermatology & Venereology Department, Ain Shams University hospitals, from March 2016 till August 2016.Serum desnutrin assessment was done by ELISA kit using Sandwich-ELISA as a method. The Micro elisa stripplate has been pre-coated with a Horse Radish Peroxidase antibody specific to desnutrin. The optical density was measured spectrophotometrically. Results: There was a significantly lower level of serum desnutrin among cases compared to that of control group, while the fasting blood glucose level was significantly higher among cases compared to that of control group. The collective data from both study groups showed a significant negative correlation between the mean serum fasting blood glucose level and desnutrin level. There was no significant correlation between the severity of acne and serum desnutrin level. Conclusion: The level of serum desnutrin can affect the occurrence and the progression but not the severity of acne among susceptible individuals. The level of fasting blood glucose is also of value regarding the occurrence of acne and has a negative effect on the level of desnutrin.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 85%

See 2 more Smart Citations

Assessment of Serum Desnutrin Levels in Patients with Acne Vulgaris

Saleha

Shararab

Habib

2017

EJHM

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“…Patients with acne often exhibit increased levels of serum glucose and insulin as well as insulin resistance, and its association has been long recognized [72]. Interestingly, in patients with acne vulgaris, desnutrin, also called adipose triglyceride lipase (ATGL), has been found to be low and to have a positive correlation with insulin and HOMA-IR values [73]. In this patient hyperandrogenemia promoted comedone production by increasing the size of the sebaceous glands and therefore increased sebum production and produced abnormal follicular keratinization [65].…”

Section: Introductionmentioning

confidence: 99%

Skin Manifestations of Insulin Resistance: From a Biochemical Stance to a Clinical Diagnosis and Management

González-Saldivar

Rodríguez-Gutiérrez

Ocampo‐Candiani

et al. 2016

Dermatol Ther (Heidelb)

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Worldwide, more than 1.9 billion adults are overweight, and around 600 million people suffer from obesity. Similarly, ~382 million individuals live with diabetes, and 40–50% of the global population is labeled at “high risk” (i.e., prediabetes). The impact of these two chronic conditions relies not only on the burden of illnesses per se (i.e., associated increased morbidity and mortality), but also on their increased cost, burden of treatment, and decreased health-related quality of life. For this review a comprehensive search in several databases including PubMed (MEDLINE), Ovid EMBASE, Web of Science, and Scopus was conducted. In both diabetes and obesity, genetic, epigenetic, and environmental factors overlap and are inclusive rather than exclusive. De facto, 70–80% of the patients with obesity and virtually every patient with type 2 diabetes have insulin resistance. Insulin resistance is a well-known pathophysiologic factor in the development of type 2 diabetes, characteristically appearing years before its diagnosis. The gold standard for insulin resistance diagnosis (the euglycemic insulin clamp) is a complex, invasive, costly, and hence unfeasible test to implement in clinical practice. Likewise, laboratory measures and derived indexes [e.g., homeostasis model assessment of insulin resistance (HOMA-IR-)] are indirect, imprecise, and not highly accurate and reproducible tests. However, skin manifestations of insulin resistance (e.g., acrochordons, acanthosis nigricans, androgenetic alopecia, acne, hirsutism) offer a reliable, straightforward, and real-time way to detect insulin resistance. The objective of this review is to aid clinicians in recognizing skin manifestations of insulin resistance. Diagnosing these skin manifestations accurately may cascade positively in the patient’s health by triggering an adequate metabolic evaluation, a timely treatment or referral with the ultimate objective of decreasing diabetes and obesity burden, and improving the health and the quality of care for these patients.

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