Changes in Serum Levels of Tumor Necrosis Factor-Alpha and Antioxidant status in Different Stages of Malignant Prostate Cancer Patients in Iraq

Abstract

Chronic inflammation can induce proliferative events and posttranslational DNA modifications in prostate tissue through oxidative stress. The present study was designed to evaluate the changes in serum levels of TNF-α, malomdialdehyde (MDA) and total antioxidant status (TAS) patients with different stages of malignant prostatic cancer (PCa) and benign prostatic hyperplasia (BPH). One hundred males (age range of 58-72 years) with different stages of malignant PCa were recruited from the Radiotherapy and Nuclear Medicine Teaching Hospital in Baghdad during the period from September 2010 to April 2011. The patients were categorized according to the 4 disease stages (I, II, III, and IV); 25 patients with benign prostatic hyperplasia (BPH) and 25 normal healthy subjects were considered as comparator groups. Blood samples were taken from all subjects for analysis of TNF-α TAS and MDA levels. The results showed significant differences between the four stages of PCa patients in all parameters; however, highly significant difference was observed in stage IV compared to control and BPH patients. In conclusion, TNF-α and total antioxidant status could be utilized for marking the advanced stages of malignant PCa. 
 Key words: Malignant Prostate cancer, Inflammation, TNF-α, Oxidative stress

Evaluation the level of human kallikrein-2-hk2, prostate specific antigen and some biochemical parameters in sera of patients with prostate disease

“…It is clear from the results of the current study that the patients are oxidatively stressed, as they have a high level of malondialdehyde and a decrease in the level of glutathione in the blood serum. The studies also indicated that the level of total antioxidants varies with the degree of disease, whether for patients with PC or patients with BPH, so the study suggested evaluating the level of TAC to monitor the progress of the disease (45) .…”

Clausena Excavata Yaprak Fraksi̇yonlarinin Bağişiklik Hücreleri̇nde Reakti̇f Oksi̇jen Türleri̇ni̇n Üreti̇mi̇ni̇ Azaltarak Gösterdi̇ği̇ Immünomodülatör Etki̇nli̇k

“…During higher oxidative stress, the antioxidant system of host cells and tissues could not counteract over produced ROS due to which excess ROS react with DNA, protein consequently leading to the progression of chronic inflammatory related diseases. In natural products, there are many compounds which possess antioxidant property therefore these can prevent oxidative stress and prevent damage to cells caused by foreign xenobiotics and thereby balancing oxidative stress level and prevent progression of inflammatory diseases [3][4][5][6].…”