Changes in Serum Lipids and Blood Glucose in Non Diabetic Patients with Metabolic Syndrome after Mixed Meals of Different Composition

Abstract

Aims. To investigate the postprandial changes in serum lipoproteins and blood glucose and to verify whether different nutrient composition of the meal elicits different response in patients with (MetS+) and without (MetS−) metabolic syndrome. Research Design and Methods. 50 MetS+ patients and 50 age- and sex-matched MetS− consumed a regular lunch chosen among those more similar to their usual diet. Blood was drawn in the morning after 12-hour fasting and 2 and 4:30 hours after the meal. Results. Serum triglycerides increased more in MetS+ (35%, 4:30 hours after the meal) than in MetS− (29%), HDL-cholesterol decreased 2 hours after the meal in both groups (−4% and −5%, resp.). Blood sugar similarly increased in both groups (19%, 2 hours after the meal in MetS+ and 17% in MetS−) and plasma insulin increased more and remained high longer in MetS+ (73.5 and 52.3 μU/mL, 2 and 4:30 hours after the meal) than in MetS− (46.7 and 21.6 μU/mL). Difference in nutrient composition of the meal (carbohydrate 57%, fat 28% versus carbohydrate 45%, fat 35%) was not associated with differences in postprandial levels of triglycerides, HDL-cholesterol, glucose, and insulin within each group. Conclusions. As compared with MetS−, MetS+ patients show a greater hypertriglyceridemic and hyperinsulinemic response to a regular lunch whatever the carbohydrate or fat content of the meal.

Effect of acute hyperinsulinemia on magnesium homeostasis in humans

“…The limitations of our study include the supraphysiologic level of serum insulin (150 mU/L, equivalent to 1nM used in vitro) used in our clamp as compared with that of normal postprandial state (40‐80 mU/L), which may induce nonphysiologic effects . No specific tracing of target cell (erythrocytes, platelets, etc) of magnesium's transcellular shift was performed in our in vivo human studies, and intracellular magnesium levels were not directly measured.…”

“…49 The limitations of our study include the supraphysiologic level of serum insulin (150 mU/L, equivalent to 1nM used in vitro) used in our clamp as compared with that of normal postprandial state (40-80 mU/L), which may induce nonphysiologic effects. 50,51 No specific tracing of target cell (erythrocytes, platelets, etc) of magnesium's transcellular shift was performed in our in vivo human studies, and intracellular magnesium levels were not directly measured. Our estimated magnitude of transcellular shift could be affected by our assumptions made while calculating transcellular shifts (TBW was assumed as three-quarters of lean body mass, 23 and extracellular fluid volume was estimated as one-third of TBW 24 ), and errors through body fat composition measurement by dual-energy x-ray absorptiometry.…”

Fasting time and lipid parameters: association with hepatic steatosis — data from a random population sample

“…These patients would have evaded detection with fasting triglyceride measurements alone. Disturbances of postprandial triglyceride clearance with very high and protracted plasma triglyceride concentrations have been described in persons with insulin resistance [ 12 ] and associated disorders, such as metabolic syndrome [ 19 - 22 ] and hepatic steatosis [ 23 - 25 ]. Hence, fasting measurement might lead to an inaccurate assessment of the ordinarily very predominant plasma triglyceride concentration in these patients.…”

Walnut Trim down Lipid Profile and BMI in Obese Male in Different Ethnic Groups of Quetta Population, Pakistan

“…The recent investigations indicate that these parameters are essential in study of characteristics of obesity. Branchi has studied serum lipids in patients of metabolic syndrome while subjecting them meals of different composition [13].…”