Changes in serum parameters associated with iron metabolism in male rat exposed to lead

Abstract

Due to the severe hazardous influences of lead (Pb(2+)) on iron-related diseases, the effects of Pb(2+) on serum parameters associated with iron metabolism have been studied in this project. Male Wistar rats weighing 200-250 g were treated with Pb(2+) for the short and long period of times. The animals received daily intraperitoneal injection of 100 mg Pb(2+) kg(-1) body weight (BW) for 5 days and 4 mg kg(-1) BW of Pb(2+) for 30 and 45 days, respectively. The results show that when animals were treated with both low and high concentrations of Pb(2+), serum iron concentration decreased markedly, by 23.2, 32.8, and 39.9 %, while the sera TIBC and transferrin concentrations increased significantly (p < 0.05). Following short- and long-term exposures to Pb(2+), the percentage of serum transferrin saturation was also decreased in comparison with the untreated control group (p < 0.05). Concentrations of serum copper and ceruloplasmin following Pb(2+) treatments also reduced significantly (p < 0.05). The percentage of hematocrit and hemoglobin levels was reduced (p < 0.05) in all Pb(2+)-treated animals in comparison with the controls. These results suggest that Pb(2+) changes the serum parameters related to iron metabolism, which may play an important role in producing iron-related diseases.

Iron, hepcidin, and the metal connection

“…In addition, lead has been reported to limit the transfer of iron from endosomes toward the cytoplasm (Qian et al, 1997). More recently, lead exposure in rats was reported to decrease serum iron and transferrin saturation levels (Moshtaghie et al, 2013). In workers exposed to lead, copper, and ceruloplasmin serum concentrations are increased, but no significant alteration in iron and zinc serum levels has been found (Kasperczyk et al, 2012).…”

PAMPS-graft-Ni3Si2O5(OH)4 multiwalled nanotubes as a novel nano-sorbent for the effective removal of Pb(ii) ions

“…Compared with the spectra of the free PAMPS-g-Ni 3 Si 2 O 5 (OH) 4 NTs shown in Fig. 3, new peaks of Pb 4f and Pb 4d were observed at 139.11 eV and 414.1 eV, respectively, in the total scans of the XPS spectra of the metals aer adsorption (Fig.…”

“…The preparation protocol for PAMPS-g-Ni 3 Si 2 O 5 (OH) 4 NTs included four main steps. In the rst step, the Ni 3 Si 2 O 5 (OH) 4 NTs were prepared by a hydrothermal reaction method as previously reported. 35 In the second step, the…”

“…[38][39][40] Fig. 4B 4 . It can be observed that the adsorption rate of Pb(II) is very fast; this is consistent with the previously reported fact that the fast adsorption rate in the case of nanostructures is due to the short diffusion path and low diffusion resistance of nanostructures.…”

“…With the rapid development of social modernization, wastewater containing heavy metal ions is produced mainly from the metallurgy, tanning, battery and chemical manufacturing industries, which is causing a negative effect on the environment and human health. [1][2][3] Pb(II), ranked second in the list of prioritized hazardous substances issued by the US Agency for toxic substances and Disease Registry, has attracted signicant concern as it can cause encephalopathy, 4 hepatitis, 5 nephritic syndrome and high blood pressure 6 even at low concentrations. In recent years, many technologies, such as chemical precipitation, electrodeposition, ion exchange, coagulation and adsorption, have been applied to remove Pb(II) from wastewater.…”