Changes in serum triglycerides and high-density lipoprotein concentration and composition after a low-fat mixed meal. Effects of gender and insulin resistance

Abstract

Ingestion of low doses of fat in a mixed meal is followed by variable increases of serum TG, and the greatest response is found in insulin-resistant men. In this subset of subjects, postprandial hypertriglyceridaemia is associated with alterations in HDL that might be consistent with an increased risk of cardiovascular disease.

Fasting time and lipid parameters: association with hepatic steatosis — data from a random population sample

“…In all fasting groups, men had significantly higher triglyceride concentrations than did women. This supports the observation that men experience a more pronounced postprandial spike in triglyceride concentrations than do women [12,18]. In agreement with the above-cited population-based studies, however, our results confirm that triglyceride concentrations are most dependent on the duration of the pre-phlebotomy fasting period and that this variability is most pronounced at early postprandial measurement.…”

“…These patients would have evaded detection with fasting triglyceride measurements alone. Disturbances of postprandial triglyceride clearance with very high and protracted plasma triglyceride concentrations have been described in persons with insulin resistance [12] and associated disorders, such as metabolic syndrome [19-22] and hepatic steatosis [23-25]. Hence, fasting measurement might lead to an inaccurate assessment of the ordinarily very predominant plasma triglyceride concentration in these patients.…”

“…Some studies, however, suggest that the predictive value of non-fasting triglyceride levels for cardiovascular disease is comparable to [8,9] or even superior to that of concentrations determined in fasting subjects [6,10,11]. Because humans normally are in a non-fasting condition during much of the day, it might be argued that lipid measurements obtained in a non-fasting subject are in fact more representative of the current metabolic status and may provide better evidence for potential disorders of postprandial lipid metabolism [1,2,9,12,13]. …”

Diagnostic Value of Postprandial Triglyceride Testing in Healthy Subjects:A Meta-Analysis

“…These results are also limited to healthy Caucasians with a body mass index <30 kg/m 2 and without consid-. TG SMD 2nd hour-baseline (mmol/1) (12,288) ering potential differences between men and women as previously reported [31,[124][125][126][127][128][129].…”

Should We Fast Before We Measure Our Lipids?

“…In particular, triglyceride levels vary considerably depending on the length of fasting. 3 On the con side, there are logistic challenges and inefficiencies that have not been fully quantified. Patients are often inconvenienced by having to return on a separate visit.…”