Changes in sex hormone‐binding globulin and testosterone during weight loss and weight maintenance in abdominally obese men with the metabolic syndrome

Niskanen, Leo; Laaksonen, David E.; Punnonen, Kari; Mustajoki, Pertti; Kaukua, Jarmo; Rissanen, Aila

doi:10.1111/j.1462-8902.2004.00335.x

Cited by 248 publications

(167 citation statements)

References 44 publications

Supporting

Mentioning

142

Contrasting

Unclassified

Order By: Relevance

“…5 Weight loss was associated with a decrease in fasting insulin levels, increased mean plasma SHBG and total testosterone levels in both diabetic and nondiabetic intervention subjects, and free testosterone only in the diabetic men. This finding is concordant with that of other studies, which demonstrated improvements in total, 29 bioavailable 16 and free 29 testosterone levels after caloric restriction. For example, in a mixed group of diabetic and nondiabetic obese men, SHBG, total and free testosterone levels increased in response to a mean weight loss of 21 kg after 10 weeks of LCD.…”

Section: Discussionsupporting

confidence: 83%

“…16 Furthermore, in obese middle-aged men with the metabolic syndrome (B25% of whom were diabetic), weight loss of B14% induced by 9 weeks of LCD (800 kcal per day) increased total and free testosterone and SHBG levels. 29 In our study, the increase in total testosterone was correlated with the magnitude of weight loss and reduction in WC, possibly because of reduced insulin resistance; 5,30 moreover, aromatase activity in adipose tissue results in increased estradiol production, decreased pituitary gonadotropin production and reduction in testicular synthesis of testosterone. 31 In obese women, urinary symptoms and incontinence are improved by weight loss, 32 but there is a paucity of similar data in men.…”

Section: Discussionmentioning

confidence: 84%

“…The International Prostate Symptom Scale (IPSS) is a series of questions used to assess the severity of irritative (frequency, urgency, nocturia) and obstructive LUTSs (incomplete emptying, intermittency, weak stream, straining), attributable to bladder outlet obstruction caused by prostatic enlargement. 19 Symptoms are classified as mild (score 0-7), moderate (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) or severe (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35).…”

Section: Questionnairesmentioning

confidence: 99%

See 2 more Smart Citations

Effects of a low-energy diet on sexual function and lower urinary tract symptoms in obese men

et al. 2010

View full text Add to dashboard Cite

Objective: Abdominal obesity and type 2 diabetes mellitus are associated with erectile and urinary dysfunction in men. The extent to which sexual function and lower urinary tract symptoms (LUTSs) are improved by weight loss remains unclear. Subjects: We compared the effects of 8 weeks of a low-calorie diet using meal replacements (Kicstart) on insulin sensitivity, plasma testosterone levels, erectile function (measured by the five-item version of the International Index of Erectile Function, IIEF-5), sexual desire (measured by the Sexual Desire Inventory, SDI) and LUTS (measured by the International Prostate Symptom Score, IPSS), in abdominally obese (body mass index X30 kg m À2 , waist circumference (WC) X102 cm) men (mean age 49.7 years) with uncomplicated diet or oral hypoglycemic-treated type 2 diabetes mellitus (n ¼ 19) or without type 2 diabetes mellitus (n ¼ 25), with a control group of nondiabetic men (n ¼ 26) with similar body mass index and WC. Results: Weight loss of B10% was significantly associated with increased insulin sensitivity, plasma testosterone levels, IIEF-5 and SDI scores, as well as reduced WC and IPSS scores, in diabetic as well as nondiabetic men. The degree of weight loss was significantly associated with improvements in plasma testosterone levels (r ¼ À0.34), erectile function (r ¼ À0.26) and LUTS (r ¼ 0.65). Reduction in LUTS was significantly associated with increased plasma testosterone (r ¼ À0.35), erectile function (r ¼ À0.42) and sexual desire (r ¼ À0.40). Conclusions: Diet-induced weight loss significantly and rapidly improves sexual function, and reduces LUTS, in obese middleaged men with or without diabetes.

show abstract

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 84%

Section: Questionnairesmentioning

confidence: 99%

See 1 more Smart Citation

Effects of a low-energy diet on sexual function and lower urinary tract symptoms in obese men

et al. 2010

View full text Add to dashboard Cite

show abstract

“…For example, weight loss has been shown to improve testosterone levels, reducing fat mass and estrogen levels [135,136]. Modification may apply to changing prescription or nonprescription drug use and/or altering psychosocial factors [4].…”

Section: Step Care 3: Modifying Reversible Causesmentioning

confidence: 99%

Testosterone and Erectile Function: From Basic Research to a New Clinical Paradigm for Managing Men with Androgen Insufficiency and Erectile Dysfunction

2007

View full text Add to dashboard Cite

Objectives-Androgens are essential for the development and growth of the penis, and they regulate erectile physiology by multiple mechanisms. Our goal is to provide a concise overview of the basic research and how this knowledge can be translated into a new clinical paradigm for patient management. In addition, this new paradigm may serve as a basis for stimulating constructive debate regarding the use of testosterone in men, and to promote new, innovative basic and clinical research to further understand the underlying mechanisms of androgen action in restoring erectile physiology. Methods-A literature review was performed utilizing the US National Library of Medicine's PubMed database.Results-On the basis of evidence derived from laboratory animal studies and clinical data, we postulate that androgen insufficiency disrupts cellular-signaling pathways and produces pathologic alterations in penile tissues, leading to erectile dysfunction. In this review, we discuss androgendependent cellular, molecular, and physiologic mechanisms modulating erectile function in the animal model, and the implication of this knowledge in testosterone use in the clinical setting to treat erectile dysfunction. The new clinical paradigm incorporates many of the consensed points of view discussed in traditional consensed algorithms exclusively designed for men with androgen insufficiency. There are, however, novel and innovative differences with this new clinical paradigm. This paradigm represents a fresh effort to provide mandatory and optional management strategies for men with both androgen insufficiency and erectile dysfunction. Conclusions-The new clinical paradigm is evidence-based and represents one of the first attempts to address a logical management plan for men with concomitant hormonal and sexual health concerns.

show abstract

“…Weight loss in obese men with metabolic syndrome has been shown to increase testosterone levels and reduce the complications of long-term hypogonadism. 33 …”

Section: Hypogonadismmentioning

confidence: 99%

Metabolic syndrome and common urological conditions: looking beyond the obvious

Rees

Kirby

2014

Trends Urol & Men's Health

View full text Add to dashboard Cite

show abstract

Changes in sex hormone‐binding globulin and testosterone during weight loss and weight maintenance in abdominally obese men with the metabolic syndrome

Cited by 248 publications

References 44 publications

Effects of a low-energy diet on sexual function and lower urinary tract symptoms in obese men

Effects of a low-energy diet on sexual function and lower urinary tract symptoms in obese men

Testosterone and Erectile Function: From Basic Research to a New Clinical Paradigm for Managing Men with Androgen Insufficiency and Erectile Dysfunction

Metabolic syndrome and common urological conditions: looking beyond the obvious

Contact Info

Product

Resources

About