Background: In the past years, HIV prevention efforts have increased with focus on people living with HIV and AIDS (PLWHA) in addition to addressing risk reduction efforts targeting HIV-uninfected individuals. HIV prevalence is 6.3% in Yaounde. This prevalence calls for improvement of prevention strategies. In Cameroon, sensitization activities are continuous and preventive strategy is directed towards HIV negative people. We assessed the suitability of positive prevention in Cameroon, through the comparison of risky behaviors between HIV infected and non-infected people.Methods: HIV positive and HIV negative people were recruited in the capital city of Cameroon. Data were collected through a structured questionnaire, pretested and validated, before and after the knowledge of HIV status. The information collected include: Age at first sexual intercourse, number of sexual partners, usage of condoms and frequency of sexual intercourses.