2006
DOI: 10.1186/1471-2164-7-320
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Changes in skeletal muscle gene expression following clenbuterol administration

Abstract: Background: Beta-adrenergic receptor agonists (BA) induce skeletal muscle hypertrophy, yet specific mechanisms that lead to this effect are not well understood. The objective of this research was to identify novel genes and physiological pathways that potentially facilitate BA induced skeletal muscle growth. The Affymetrix platform was utilized to identify gene expression changes in mouse skeletal muscle 24 hours and 10 days after administration of the BA clenbuterol.

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Cited by 57 publications
(53 citation statements)
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“…The observation that β 2 ‐agonist treatment alters training‐induced remodelling of proteome signature and phenotype in relation to oxidative capacity, as well as metabolic and contractile properties of skeletal muscle, coincides with the acute and temporal changes in gene transcription profile observed in rodent skeletal muscle upon β 2 ‐adrenergic stimulation (Spurlock et al . ; Pearen et al . ).…”
Section: Discussionmentioning
confidence: 99%
“…The observation that β 2 ‐agonist treatment alters training‐induced remodelling of proteome signature and phenotype in relation to oxidative capacity, as well as metabolic and contractile properties of skeletal muscle, coincides with the acute and temporal changes in gene transcription profile observed in rodent skeletal muscle upon β 2 ‐adrenergic stimulation (Spurlock et al . ; Pearen et al . ).…”
Section: Discussionmentioning
confidence: 99%
“…The mechanisms underlying the growth‐promoting actions of beta 2 ‐agonists, however, are not entirely clear, although they involve modulation of various signalling pathways and gene programs that regulate muscle protein synthesis and proteolysis in rodents (Spurlock et al . ; Pearen et al . ; Koopman et al .…”
Section: Introductionmentioning
confidence: 99%
“…), which have a wide range of downstream targets that regulate ribosomal translation processes and transcription of growth‐modulating genes (Spurlock et al . ; Pearen et al . ), including cAMP response element binding protein (CREB) (Hinkle et al .…”
Section: Introductionmentioning
confidence: 99%
“…for 3 days and 3.2 μg/kg bwt b. a pharmacodynamic or physiological effect. Perhaps even more importantly, with respect to potential performance-enhancing (anabolic) effects, based on studies in other species [1][2][3][4][5]22], much higher plasma concentrations than those necessary to elicit a bronchodilatory (therapeutic) effect would probably be necessary for any potential anabolic effect. However, the plasma and urine concentrations achieved in the present study are based on administration of the US Food and Drug Administration-approved clenbuterol product at the labelled dose, and the results obtained here do not necessarily apply to extralabel administration or to use of compounded formulations.…”
Section: Discussionmentioning
confidence: 99%