Changes in Sociability and Preference for Social Novelty in Female Rats in Prolonged Social Isolation

Shirenova, S.; Хлебникова, Н. Н.; Krupina, N. A.

doi:10.1007/s11055-023-01395-8

Cited by 5 publications

(2 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings are largely consistent with other studies conducted in rats (Bishnoi et al, 2021; Knight et al, 2021), although sex differences are not always seen across both behavioral tests (Scholl et al, 2019). The majority of social isolation studies have been conducted in males (Kinley et al, 2021; Walker et al, 2019) and suggest that isolation effects can vary based on strain and timing of isolation (Burke et al, 2017; Oliveira et al, 2019; Shirenova et al, 2023). Additionally, whether the sex differences related to locomotion or anxiety have been the subject of discussion (Bishnoi et al, 2021; Brenes et al, 2009; Fernandes et al, 1999; Silvestre et al, 1999; Walker et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Sex differences in behavior and glutamic acid decarboxylase in Long Evans rats after prolonged social isolation beginning in adolescence.

Harding,

Van Dyke,

Little

et al. 2024

Behavioral Neuroscience

View full text Add to dashboard Cite

Social isolation can have long-term effects on brain development and behavior and increases the risk of developing clinical conditions, including anxiety disorders. One modulator of the stress response is gamma-aminobutyric acid, an inhibitory neurotransmitter synthesized by glutamic acid decarboxylase (GAD). This study examined sex differences in behavior and GAD expression following prolonged social isolation beginning in adolescence in Long Evans rats. Males and females were equally divided into group-housed (GH) and socially isolated conditions on Postnatal Day 28 (n = 8 per group). Beginning 5 weeks later, tests were conducted for anxietylike behaviors (open-field test and elevated plus maze), social interactions (sociability test), and spatial memory (novel object location). Sex differences in behavior were observed, with GH females showing fewer anxietylike behaviors in the open-field test and elevated plus maze and spending more time with objects (sociability task) compared to GH males. Isolation had no effect on males but increased anxiety and reduced neophilic measures in females, removing sex differences. On the sociability task, all groups spent more time with novel rats compared to objects, suggesting social interest was retained after isolation. In the hippocampus, isolation reduced GAD in both sexes, and sex differences were seen (F > M). However, no group differences in behavior were observed in the hippocampal-dependent novel object location task. Our findings suggest that prolonged social isolation beginning in adolescence is anxiogenic for female Long Evans rats. Furthermore, sex and housing impact hippocampal GABA-ergic activity, which may have important implications in the treatment of anxiety disorders.

show abstract

Section: Discussionmentioning

confidence: 99%

Sex differences in behavior and glutamic acid decarboxylase in Long Evans rats after prolonged social isolation beginning in adolescence.

Harding,

Van Dyke,

Little

et al. 2024

Behavioral Neuroscience

View full text Add to dashboard Cite

show abstract

“…Social interaction might be assessed in a couple of freely moving animals, placed in a simple or enriched context [ 12 , 29 , 30 , 31 ]. Alternatively, “guest” animals might be fixed with tether and collar assemblies [ 30 , 32 ], separated in a compartment of the test arena [ 33 , 34 , 35 ], or encaged [ 36 , 37 , 38 ]. The social stimuli might be isolated by partitions, which specifically limit or restrict visual, audial, haptic, or olfactory sensory inputs involved in animal interactions [ 39 , 40 , 41 ].…”

Section: Methodsmentioning

confidence: 99%

Audiogenic Seizures and Social Deficits: No Aggravation Found in Krushinsky–Molodkina Rats

Rebik,

Broshevitskaya,

Kuzhuget

et al. 2023

Biomedicines

View full text Add to dashboard Cite

Epilepsy or epileptic syndromes affect more than 70 million people, often comorbid with autism spectrum disorders (ASD). Seizures are concerned as a factor for social regression in ASD. A stepwise experimental approach to this problem requires an animal model to provoke seizures and monitor subsequent behavior. We used rats of the Krushinsky–Molodkina (KM) strain as a validated inbred genetic model for human temporal lobe epilepsy, with recently described social deficiency and hypolocomotion. Generalized tonic-clonic seizures in KM rats are sound-triggered, thus being controlled events in drug-naïve animals. We studied whether seizure experience would aggravate contact deficits in these animals. Locomotor and contact parameters were registered in “the elevated plus maze”, “socially enriched open field”, and “social novelty/social preference tests” before and after sound-provoked seizures. The triple seizure provocations minimally affected the contact behavior. The lack of social drive in KM rats was not accompanied by a submissive phenotype, as tested in “the tube dominance test”, but featured with a poor contact repertoire. Here, we confirmed our previous findings on social deficits in KM rats. The contact deficiency was dissociated from hypolocomotion and anxiety and did not correlate with seizure experience. It was established that experience of rare, generalized tonic-clonic convulsions did not lead to an impending regress in contact motivation, as seen in an animal model of genetic epilepsy and comorbid social deficiency. One of the oldest animal models for epilepsy has a translational potential to study mechanisms of social behavioral deficits in future neurophysiological and pharmacological research.

show abstract

Repeated toluene inhalation in male and female adolescent rats induces persistent drug preference and impairs cognitive and social behavior

Asis,

Carampel,

Bacar

et al. 2024

Psychopharmacology

View full text Add to dashboard Cite

Changes in Sociability and Preference for Social Novelty in Female Rats in Prolonged Social Isolation

Cited by 5 publications

References 61 publications

Sex differences in behavior and glutamic acid decarboxylase in Long Evans rats after prolonged social isolation beginning in adolescence.

Sex differences in behavior and glutamic acid decarboxylase in Long Evans rats after prolonged social isolation beginning in adolescence.

Audiogenic Seizures and Social Deficits: No Aggravation Found in Krushinsky–Molodkina Rats

Repeated toluene inhalation in male and female adolescent rats induces persistent drug preference and impairs cognitive and social behavior

Contact Info

Product

Resources

About