Tillage systems can affect soil compaction, water content, soil temperature, and yields of cultivated plants. This work examined a Vertisol and the influence of the tillage system on soil compaction and yield of winter wheat (Triticum aestivum L.) grains. The trial was conducted in the vicinity of Požega, Western Serbia, from 2014 to 2017. Four tillage systems (conventional tillage, reduced tillage, disc harrowing, and no-tillage) were applied in the experiment. Tillage systems have significantly influenced soil compaction, measurement time, and soil depth.