Changes in succinate dehydrogenase activity in various parts of the brain during combined exposure to vibration and licorice root

Abstract

Data obtained in the studies reported here provide evidence that during exposure to vibration for 30 days, feeding with licorice root significantly increases the activity of the anaerobic respiration enzyme succinate dehydrogenase (SDH) in the cerebral cortex, while activity in the subcortex, conversely, decreases. Combined treatment for 30 days with licorice root and vibration after a preliminary 30-day period of feeding with licorice root resulted in high SDH activity in all the structures studied, improving brain energy supply and metabolism and ameliorating the effect of vibration.

Review of Pharmacological Effects of Glycyrrhiza sp. and its Bioactive Compounds

“…Moreover, chronic administration of the extract of G. glabra in both low and high doses induced correction of the passive avoidance performance in ovariectomized female rats (Fedotova et al, 2005). Combined treatment with licorice root and vibration resulted in increased succinate dehydrogenase (SDH) activity in different parts of the brain, improved brain energy supply and ameliorated the effect of vibration (Oganisyan et al, 2005). In addition, isoliquiritigenin showed protective effects in cerebral ischemia-reperfusion injury in rats ( Zhan and Yang, 2006).…”

Phytochemical composition, health effects, and crop management of liquorice (Glycyrrhiza glabraL.): Α medicinal plant

“…(93) Furthermore, liquorice extracts and their individual bioactive compounds provide several other health benefits for kidney, cardiovascular, immunological, respiratory, endocrine and central nervous systems which need to be underlined, since so far many physiological effects of liquorice on human body systems have been confirmed. (66,85,(100)(101)(102)(103)(104)(105)(106)(107)(108)(109)(110)(111)(112)(113)(114) The health benefits of liquorice and its constituents have been suggested to be attributed to various physiological mechanisms, including modulation of vascular injury and atherogenesis, (111) inhibition of tyrosinase activity, (103) improvement of the brain energy supply, (110) increased glucose tolerance, (112) activation of the immune system, (101) protection against the oxidative stress of the liver, (95) memory enhancing effects (105) and improvement of the renal function. (114) Other physiological effects of liquorice on human body systems are presented in Table 2.…”

Regulation of Fish Antioxidant System With Biologically Active Feed Additives

“…Под воздействием стресса у рыб повышается перекисное окисление липидов на кристах митохондрий при синтезе АТФ [7], вследствие чего образуются свободные радикалы, которые повреждают биомембраны [8][9] и нарушают их функции. Биомембраны утрачивают барьерную функцию и перестают участвовать в восприятии сигнала [10].…”