Changes in Surface Antigens of SV40-Virus Transformed Cells

Ht, Robertson; Ph, Black

doi:10.3181/00379727-130-33556

Cited by 37 publications

(7 citation statements)

References 5 publications

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“…The failure of the antiserum to react with hamster or sheep erythrocytes also excludes the possibility of a Forssman reaction of the type detected in experimental models using rabbit antiserum (Robertson and Black, 1969;Meyer et al, 1971;Kedar et al, 1971). The crossreactivity with adenovirus-1Ztransformed hamster kidney cells also raises the possibility that the immunofluorescent reaction found in that system (Vasconcelos-Costa, 1970) might be similar or identical to the one described here.…”

Section: Discussionmentioning

confidence: 99%

The SV40 S antigen; A carcinoembryonic‐type antigen of the hamster?

Berman

1972

Intl Journal of Cancer

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In addition to hamster tumor cells induced or transformed by SV40, hamster a n t i 3 V40 S (Surface) antiserum also reacted with non-SV40-exposed cell lines spontaneously induced (BHK 21) (1) Some lines of SV40-exposed hamster cells contain the S antigen, although they do not contain SV40 T antigen, SV40 tumor-specific transplantation antigen, radioimmunoassay detectable SV40-specific surface antigen or hybridizable SV40-specific RNA Tevethia et al., 1968;Wright, 1971;Levine et al., 1970); (2) the sera of pregnant hamsters have been shown to react with hamster cells containing the S antigen (Duff and Rapp, 1970); and (3) upon exposure to proteolytic enzymes, lines of non-SV40-exposed hamster cells have been shown to contain an antigen similar or identical to the SV40 S antigen (Hayry --

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Section: Discussionmentioning

confidence: 99%

The SV40 S antigen; A carcinoembryonic‐type antigen of the hamster?

Berman

1972

Intl Journal of Cancer

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“…Forssman-like antigen was also found on hamster cells transformed by SV40 or polyoma viruses (Robertson and Black, 1969;Kedar et ai., 1971;Meyer et al, 1971). However, this antigen was not involved in the inhibitory effect of hamster embryonic tissue on SV40 transplantation immunity (Hannon et al, 1975).…”

Section: The Antigensmentioning

confidence: 98%

Immunopathology

1983

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“…Although Forssrnan antigen has been detected on the surfaces of both polyoma-and SV40-transformed hamster cells (O'Neill, 1968;Robertson and Black, 1969), neither fluorescence nor mixed haernagglutination revealed this antigen on the surface of C13/SV cells. Forssmanpositive, control Nil 2e cells gave positive results in all tests.…”

Section: Forssman Antigenmentioning

confidence: 99%

The transformation of BHK 21 hamster cells by simian virus 40

Wiblin

Macpherson

1972

Intl Journal of Cancer

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Rapp et al. (1964) did not find an enhanced tumorigenicity in BHK 21 cells treated with a multiplicity of 3 PFU SV40 virus per cell. They also showed that SV40-immunized adult hamsters were not more resistant to the transplantability of the virus-exposed cells. Black and Rowe (1965) found a growth stimulatory effect on BHK 21/13 cells after exposure to hypertonic saline and SV40 DNA, but a more intensive clonal study would have been desirable in this case to ensure that the differences found between test and control cultures were not due to heterogeneity and selection from the parental stock of cells.Here we describe the successful transformation of BHK 21/13 cells following their cocultivation with SV40-infected monkey cells. MATERIAL AND METHODS Cells(a) BHK 21/13. The origins of the diploid fibroblastic cell line BHK 21, and its derivative clone 13 (C13) have been described (Macpherson and Stoker, 1962). (b) BS-C-I cells, a line derived from African Green Monkey Kidney cells (Hopps et al., 1963), were obtained from Flow

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Changes in Surface Antigens of SV40-Virus Transformed Cells

Cited by 37 publications

References 5 publications

The SV40 S antigen; A carcinoembryonic‐type antigen of the hamster?

The SV40 S antigen; A carcinoembryonic‐type antigen of the hamster?

Immunopathology

The transformation of BHK 21 hamster cells by simian virus 40

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