Changes in the 24 h Rhythmicity of Liver PPARs and Peroxisomal Markers When Feeding Is Restricted to Two Daytime Hours

Rivera-Zavala, Julieta Berenice; Báez-Ruíz, Adrian; Dı́az-Muñoz, Mauricio

doi:10.1155/2011/261584

Cited by 16 publications

(24 citation statements)

References 42 publications

(55 reference statements)

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“…Three ABC transporters belonging to subfamily D have been identified in mammalian peroxisomes (73). ABCD3, also known as peroxisomal membrane protein 70 (PMP70), is experimentally used as a structural marker of peroxisomes (86).…”

mentioning

confidence: 99%

Peroxisomes and Kidney Injury

Vasko

2016

Antioxidants & Redox Signaling

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Significance: Peroxisomes are organelles present in most eukaryotic cells. The organs with the highest density of peroxisomes are the liver and kidneys. Peroxisomes possess more than fifty enzymes and fulfill a multitude of biological tasks. They actively participate in apoptosis, innate immunity, and inflammation. In recent years, a considerable amount of evidence has been collected to support the involvement of peroxisomes in the pathogenesis of kidney injury. Recent Advances: The nature of the two most important peroxisomal tasks, betaoxidation of fatty acids and hydrogen peroxide turnover, functionally relates peroxisomes to mitochondria. Further support for their communication and cooperation is furnished by the evidence that both organelles share the components of their division machinery. Until recently, the majority of studies on the molecular mechanisms of kidney injury focused primarily on mitochondria and neglected peroxisomes. Critical Issues: The aim of this concise review is to introduce the reader to the field of peroxisome biology and to provide an overview of the evidence about the contribution of peroxisomes to the development and progression of kidney injury. The topics of renal ischemia-reperfusion injury, endotoxin-induced kidney injury, diabetic nephropathy, and tubulointerstitial fibrosis, as well as the potential therapeutic implications of peroxisome activation, are addressed in this review. Future Directions: Despite recent progress, further studies are needed to elucidate the molecular mechanisms induced by dysfunctional peroxisomes and the role of the dysregulated mitochondria-peroxisome axis in the pathogenesis of renal injury. Antioxid. Redox Signal. 25, 217-231.

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confidence: 99%

Peroxisomes and Kidney Injury

Vasko

2016

Antioxidants & Redox Signaling

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“…b ). Even though fasting and hypocaloric feeding in murine models leads to the reduced storage of GH, during FEO activation, the metabolic adaptations are different from those observed in a single 24‐h fasting . Hence, daytime dRF down‐regulates GH synthesis and secretion, and sensitises the system to respond with an increase after mealtime.…”

Section: Discussionmentioning

confidence: 99%

“…GH secretion in vivo or in vitro is dependent upon metabolic and humoural factors, and it is regulated in a complex manner . Circulating free fatty acids (FFA) inhibit GH secretion, and a peak of FFA was observed in dRF group during the time of FAA (ZT 3 h) . The lower values of blood GH could be explained by a 3‐week exposure to high glucocorticoids , a condition reported to occur in the dRF protocol .…”

Section: Discussionmentioning

confidence: 99%

Daily Patterns and Adaptation of the Ghrelin, Growth Hormone and Insulin‐Like Growth Factor‐1 System Under Daytime Food Synchronisation in Rats

Arellanes-Licea¹,

Báez-Ruíz²,

Carranza³

et al. 2014

J Neuroendocrinology

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Daytime restricted feeding promotes the re-alignment of the food entrained oscillator (FEO). Endocrine cues which secretion is regulated by the transition of fasting and feeding cycles converge in the FEO. The present study aimed to investigate the ghrelin, growth hormone (GH) and insulin-like growth factor (IGF)-1 system because their release depends on rhythmic and nutritional factors, and the output from the system influences feeding and biochemical status. In a daily sampling approach, rats that were fed ad lib. were compared with rats on a reversed (daytime) and restricted feeding schedule by 3 weeks (dRF; food access for 2 h), also assessing the effect of acute fasting and refeeding. We undertook measurements of clock protein BMAL1 and performed somatometry of peripheral organs and determined the concentration of total, acylated and unacylated ghrelin, GH and IGF-1 in both serum and in its main synthesising organs. During dRF, BMAL1 expression was synchronised to mealtime in hypophysis and liver; rats exhibited acute hyperphagia, stomach distension with a slow emptying, a phase shift in liver mass towards the dark period and decrease in mass perigonadal white adipose tissue. Total ghrelin secretion during the 24-h period increased in the dRF group as a result of elevation of the unacylated form. By contrast, GH and IGF-1 serum concentration fell, with a modification of GH daily pattern after mealtime. In the dRF group, ghrelin content in the stomach and pituitary GH content decreased, whereas hepatic IGF-1 remained equal. The daily patterns and synthesis of these hormones had a rheostatic adaptation. The endocrine adaptive response elicited suggests that it may be associated with the regulation of metabolic, behavioural and physiological processes during the paradigm of daytime restricted feeding and associated FEO activity.

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“…Control and experimental groups were similar to those reported previously by our group . Briefly, rats were randomly assigned to four groups: (i) Rats fed ad libitum (AL) for 3 weeks; (ii) Rats exposed to a daily RFS with access to food only between 12:00 and 14:00 hours for 3 weeks; (iii) Rats fasted for 21 h (Fa) and (iv) Rats that were fasted 22 h and refed for 2 h (Fa–Re) (from 12:00 to 14:00 hours).…”

Section: Methodsmentioning

confidence: 99%

Molecular and biochemical modifications of liver glutamine synthetase elicited by daytime restricted feeding

Vázquez‐Martínez

Ita-Pérez

Valdés-Fuentes

et al. 2013

Liver International

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Restricted feeding schedule induced circadian rhythmicity inmRNA levels of GS and the loss of the rhythmic pattern in mitochondrial GS activity. GS activity in liver homogenates displayed a robust rhythmic pattern in AL that was not modified by RFS. The presence of GS and its zonal distribution did not show rhythmic pattern in both groups. However, acute Fa and Fa–Re diminished GS protein and activity in liver homogenates. Hepatic glutamine concentrations showed a 24-h rhythmic pattern in both groups, in an antiphasic pattern. In conclusion, daytime RFS influences the liver GS system at different levels, that could be part of rheostatic adaptations associated to the FEO, and highlight the plasticity of this system.

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Changes in the 24 h Rhythmicity of Liver PPARs and Peroxisomal Markers When Feeding Is Restricted to Two Daytime Hours

Cited by 16 publications

References 42 publications

Peroxisomes and Kidney Injury

Peroxisomes and Kidney Injury

Daily Patterns and Adaptation of the Ghrelin, Growth Hormone and Insulin‐Like Growth Factor‐1 System Under Daytime Food Synchronisation in Rats

Molecular and biochemical modifications of liver glutamine synthetase elicited by daytime restricted feeding

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