2020
DOI: 10.1016/j.heliyon.2020.e03989
|View full text |Cite
|
Sign up to set email alerts
|

Changes in the biochemical, hematological and histopathological parameters in STZ-Induced diabetic rats and the ameliorative effect of Kigelia africana fruit extract

Abstract: Background: Biochemical, hematological and histological changes are major observable clinical and pathological factors associated with Diabetes mellitus. Derangement in the levels of these parameters increases the risk of the development of complications. In another hand, gastrointestinal intolerance due to the development of lactic acidosis on the gastrointestinal tract and the intestinal microbiome is the toxic side effect of various synthetic antidiabetic agents. The use of Kigelia africana fruit extract fo… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

5
17
1

Year Published

2020
2020
2024
2024

Publication Types

Select...
8

Relationship

1
7

Authors

Journals

citations
Cited by 27 publications
(23 citation statements)
references
References 64 publications
5
17
1
Order By: Relevance
“…The control group was injected i.p with 0.1 M sodium citrate buffer, pH 4.5 buffer. Diabetes mellitus was induced by intraperitoneally (i.p) injection of STZ (Sigma, UK) dissolved in 0.1 M sodium citrate buffer, pH 4.5 at a dose of 60 mg/kg body weight (BW) for 2 consecutive days (El‐Halawany, Barakat, Ghaly, & Ahmed, 2013; Fagbohun, Awoniran, Babalola, Agboola, & Msagati, 2020). Diabetes mellitus developed within 48 hr of STZ administration and was verified by measuring the glucose concentrations in blood samples obtained from rat tails using a glucometer.…”
Section: Methodsmentioning
confidence: 99%
“…The control group was injected i.p with 0.1 M sodium citrate buffer, pH 4.5 buffer. Diabetes mellitus was induced by intraperitoneally (i.p) injection of STZ (Sigma, UK) dissolved in 0.1 M sodium citrate buffer, pH 4.5 at a dose of 60 mg/kg body weight (BW) for 2 consecutive days (El‐Halawany, Barakat, Ghaly, & Ahmed, 2013; Fagbohun, Awoniran, Babalola, Agboola, & Msagati, 2020). Diabetes mellitus developed within 48 hr of STZ administration and was verified by measuring the glucose concentrations in blood samples obtained from rat tails using a glucometer.…”
Section: Methodsmentioning
confidence: 99%
“…The search for therapeutic plants for treating diabetes mellitus has been stimulated by the World Health Organization (WHO) due to low side effects from their prolonged and traditional use, in addition to being a low cost and significantly effective therapeutic alternative 44 .…”
Section: Discussionmentioning
confidence: 99%
“…Untreated chronic hyperglycemia leads to macro and microvascular diabetic complications. The progression of these complications triggers multiple renal, cardiac and hepatic disorders and, consequently, derangements in the biochemical, hematological and histological parameters that contribute to increase free radicals, associated with the pathophysiology of diabetes 44 .…”
Section: Discussionmentioning
confidence: 99%
“…Medicinal plants that can effectively combat the menace of DM are expected to have secondary metabolites or phytochemicals ladened with high antioxidant activities. [26] From over 400 tradomedicinal plants that have been reported for the treatment of DM, [27,28] this study screened the hexane fraction of Kigelia africana (Lam.) Benth.…”
Section: Introductionmentioning
confidence: 99%
“…From over 400 tradomedicinal plants that have been reported for the treatment of DM, [ 27,28 ] this study screened the hexane fraction of Kigelia africana (Lam.) Benth.…”
Section: Introductionmentioning
confidence: 99%