Changes in the blood complement system in the development of diabetic retinopathy in the elderly

Agarkov, N. M.; Gorko, Tatyana S.; Lev, I.V.; Shekaturov, Alexey A.; Shabalin, Aleksey A.

doi:10.18413/2658-6533-2021-7-2-0-8

RR. in B.

2021

DOI: 10.18413/2658-6533-2021-7-2-0-8

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Changes in the blood complement system in the development of diabetic retinopathy in the elderly

N. M. Agarkov¹,

Tatyana S. Gorko²,

I.V. Lev³

et al.

Abstract: Background: In the elderly, diabetic retinopathy causes a significant deterioration in the functional activity and quality of life of patients, but the individual mechanisms of its development and, in particular, the influence of the components of the blood complement system remain insufficiently studied. The aim of the study: To analyze the features of the blood complement system in elderly patients with diabetic retinopathy. Materials and methods: The components of the blood complement system were studied in… Show more

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2024

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Cited by 4 publications

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Systemic interleukin profile of elderly patients with cataract combined with senile asthenia syndrome

Фабрикантов

Osmanov

2022

Med. immunol.

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Immune disorders play an important role in development of age-related ophthalmic diseases (e.g., cataracts, age-related macular degeneration), as well as in geriatric conditions and, above all, in senile asthenia syndrome, the leading deficiency syndrome among people at their older age. However, the changes in systemic interleukins in patients with simultaneous presence of two age-associated conditions (cataract and senile asthenia syndrome) were only poorly studied. The aim of the present work was to evaluate the systemic interleukin profile in elderly patients affected by cataracts combined with senile asthenia syndrome of different severity. Patients and methods: The contents of interleukins in blood serum was analyzed in a clinical setting among patients aged 60 to 74 years for all the groups which manifested with isolated cataracts (n = 58), cataracts and senile preasthenia (n = 49), and cataracts and senile asthenia syndrome (n = 56). The diagnosis of senile asthenia syndrome was established in accordance with indexes of the phenotypic model by Fried L. et al., and cataracts, according to results of clinical ophthalmological examination. Determination of IL-1, IL-1β, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12, IL-13, IL-17 and IL-18 were performed by enzyme immunoassay followed by calculation of relative risk for each of the above interleukin, as generally accepted. Results: A statistically significant increase of IL-1, IL-1β, IL-6, IL-8, IL-13 levels, along with decrease in IL-4, IL-10 were shown in the patients presenting with combination of cataract and senile pre-asthenia, as compared with patients with only cataracts. Among the patients with cataracts and senile asthenia syndrome, the disorders were diagnosed for a large number of interleukins, with increased levels of IL-1, IL-1β, IL-6, IL-8, IL-9, IL-12, IL-13, IL-17, IL-18, and decreased concentrations of IL-4, IL-10, in comparison with cases of isolated cataract, or cataract combined with senile preasthenia. Significant values of relative risk were revealed for cataract and senile preasthenia, i.e., for IL-1 (1.27), IL-1β (1.20), IL-4 (1.21), IL-6 (1.19), IL-8 (1.93), IL-10 (2.15) and IL-13 (1.23), and, in cases of cataracts and senile asthenia syndrome, for IL-1 (1.45), IL-1β (1.31), IL-4 (1.38), IL-6 (1.57), IL-8 (2.86), IL-10 (2.39), IL-13 (1.39), IL-17 ( 1.27). The results obtained point to marked changes in the mentioned systemic interleukins among the patients aged 60 to 74 years, and more pronounced association of these changes with cataract combined with senile asthenia syndrome, than with cataract and senile preasthenia.

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Systemic interleukin profile of elderly patients with cataract combined with senile asthenia syndrome

Фабрикантов

Osmanov

2022

Med. immunol.

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Psychological Domain of Elderly Patients with Diabetic Retinopathy

et al. 2023

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The continuing increase in the prevalence of diabetic retinopathy among various segments of the population and, especially in older age, combined with a change in the psychological state of such patients. However, the study of the holistic psychological (cognitivedepressive) domain in elderly patients with various stages of diabetic retinopathy, comparable in cardiovascular pathology, which is an independent risk factor for both diabetic retinopathy and cognitive impairment, depression not carried out.Purpose: to assess the psychological domain in patients 60–74 years old suffering from diabetic retinopathy standardized for concomitant cardiovascular pathology. In the Tambov branch of the Tambov branch of S.N. Fedorov NMRC “MNTK “Eye Microsurgery” in 2019–2020, cognitive impairment and depression were studied in 68 patients with non-proliferative, 62 patients with preproliferative and 70 elderly patients with proliferative stage on the Mini-Mental-State-Examination and Center for Epidemiologic Studies — Depression scale, respectively. The diagnosis of diabetic retinopathy established based on the results of a comprehensive ophthalmological examination. The control consisted of 59 patients with the absence of diabetic retinopathy. Patients with non-proliferative stage had mild (21.5 ± 0.3 points), and with preproliferative (17.9 ± 0.4 points) and proliferative stage (16.2 ± 0.3 points) moderate cognitive impairment. The association of cognitive impairment found with preproliferative and proliferative diabetic retinopathy. The level of depression in the non–proliferative stage was 22.4 ± 0.4 points, in the preproliferative stage — 24.8 ± 0.3 points and in the proliferative stage — 26.9 ± 0.5 points versus 19.2 ± 0.3 points in the control with a significant difference in all cases. The values of the relative risk of diabetic retinopathy stages were 1,337, 2,408 and 2,796, respectively. The revealed deterioration of the cognitive-depressive domain in elderly patients with diabetic retinopathy is important for improving compliance, the effectiveness of treatment of diabetic retinopathy and the psychological continuum.

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Key aspects of choosing antipyretic therapy in pediatric practice

Zakirova,

Moroz,

Faizullina

et al. 2024

Medicinskij sovet

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Introduction. Currently, nonsteroidal anti-inflammatory drugs with anti-inflammatory, analgesic, and antipyretic effects are widely used in clinical practice.Aim. To obtain additional data on the efficacy and safety of paracetamol and ibuprofen in children with acute respiratory infections accompanied by fever.Materials and methods. A single-center (observational) study was conducted involving 32 children (5.2 ± 1.8 years) with fever due to acute respiratory disease. At temperatures above 38.5 °C, an antipyretic in the form of forte was prescribed in an age-specific dosage according to the instructions for a course of 3 days. Patients of the first group (n = 16) were prescribed paracetamol against the background of standard therapy for the underlying disease according to the nosology, children of the second group – ibuprofen forte in syrup without fragrances, dyes and flavor additives. The average daily temperature, frequency and duration of taking the study drugs, the development of adverse reactions, a score of satisfaction with parents/legal representatives of the use of antipyretics and quality of life were taken into account.Results. The result of therapy was clinical improvement: normalization of temperature (below 37.2 °C) over time with analysis of average daily values after 1, 4 hours, 1, 2, 3 days. The patients of both groups did not need to take antipyretics after 10 hours in 47.1% of cases, after 18 hours – in 53.8%. Noted the absence of adverse drug and allergic reactions and drug rejection by children, which confirms their safety. The average satisfaction rating of parents/legal representatives was 4.87 ± 0.23 (96.2% rated the effects of the studied drugs as “satisfied” and “completely satisfied”). The quality of life improved significantly with normalization of temperature by the end of the 3 days (1.92 ± 0.07).Discussion. The drugs ibuprofen and paracetamol are safe for use in pediatric practice if the dosage rules are followed and are approved for use by the World Health Organization, the FDA and other expert organizations. In addition, the emergence of new forms of release of these drugs is most important in pediatrics.Conclusions. The study conducted allows us to state the effectiveness of paracetamol and ibuprofen in the form of tablets and forte without fragrances, dyes and flavors, when taken in the correct dosage, which resulted in the relief of fever against the background of acute respiratory infections and an improvement in the quality of life.

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Changes in the blood complement system in the development of diabetic retinopathy in the elderly

Cited by 4 publications

References 7 publications

Systemic interleukin profile of elderly patients with cataract combined with senile asthenia syndrome

Systemic interleukin profile of elderly patients with cataract combined with senile asthenia syndrome

Psychological Domain of Elderly Patients with Diabetic Retinopathy

Key aspects of choosing antipyretic therapy in pediatric practice

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