Changes in the Components of the Diffusing Capacity in Pulmonary Sarcoidosis

“…The mean value and standard deviation (SD) for each parameter were: TL^," 103 ± 12%: Kco= 102 ± 15% and V., = 102 ± 7% of predicted value 13,10], The lung transfer factor was measured with the single-breath technique of Ogilvie et al [19] as modi fied by Cotes [3]. A PK Morgan Transfer Test, Model C (P.K.…”

Section: Methodsmentioning

confidence: 99%

A Simple Method of Correcting Diffusing Capacity for Alveolar Volume Reduction in Restrictive Lung Diseases

Mangado

Inglés²,

Peces-Barba³

et al. 1987

Respiration

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We studied the discriminative power of the transfer factor (TL_C0), K_co(TL_C0/V_a) and Z_co (a corrected TL_co according to alveolar volume measured (V_a), introduced by our group), in order to differentiate diffuse interstitial disease from other restrictive diseases. Measurements were taken in 46 subjects, divided into two groups: Pure restriction (group 1: normal subjects with voluntary restriction and diseased subjects) and (2) diffuse interstitial restriction (group 2). There were no statistical differences in V_a between groups 1 and 2. TL_C0 was statistically lower in groups 1 and 2 in comparison with the control group (normal values of our laboratory in test with V_a > 90% of predicted) and showed a significant difference when group 1 was compared with group 2. Similar results (but with higher values than those of the control group) were found for K_co. A similar difference exists in Z_co only when group 2 is compared with group 1 but not when group 1 is compared with the control group. The corrected diffusion capacity Z_co yields the highest discriminative power

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“…The maximal oxygen intake, maximal pulmonary capillary blood volume, and membrane diffusing capacity normally expected for each patient at heavy exercise are given in Table VI (25)(26)(27); therefore, single breath measurements may be systematically too high on this account. Assuming that our measurements of CO diffusing capacity at full inspiration are correct, the deviations from optimal conditions that most likely account for the premature fall in arterial blood oxygen saturation ( Figure 1 ) are as follows: 1) Diffusing capacity measured at full inspiration rather than at operational lung volume will predict the limits in Figure 1 to be too high.…”

Section: Methodsmentioning

confidence: 99%

Functional Significance of a Low Pulmonary Diffusing Capacity for Carbon Monoxide*

Johnson¹,

Taylor²,

DeGraff³

1965

J. Clin. Invest.

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Diffusing capacity of the lungs imposes a theoretical limit to oxygen consumption, causing oxygen saturation of arterial blood to fall sharply if this limit is approached (1). The diffusing surface of the normal lung is so large, however, that at sea level oxygen capacity of the blood and the cardiac output rather than diffusing capacity create the major bottleneck to oxygen transport (2). Diffusion becomes an important limit only at high altitudes (3) or when diffusing capacity is reduced sufficiently by disease to cause alveolar capillary block (4).Diffusing capacity of the lungs usually is measured with respect to CO (DLco) rather than oxygen (DLO2 and oxygen transfer into pulmonary capillary blood. The red cell as well as the pulmonary membrane offers resistance to CO and oxygen transfer into blood (5, 6); the total resistance (1/DL) is the sum of the membrane and red cell resistances:

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Changes in the Components of the Diffusing Capacity in Pulmonary Sarcoidosis

Cited by 32 publications

References 28 publications

Communications

Communications

A Simple Method of Correcting Diffusing Capacity for Alveolar Volume Reduction in Restrictive Lung Diseases

Functional Significance of a Low Pulmonary Diffusing Capacity for Carbon Monoxide*

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