Changes in the concentration of free amino acids in the rat brain during postnatal development

Oja, Simo S.; Piha, R. S.

doi:10.1016/0024-3205(66)90193-7

Cited by 52 publications

(23 citation statements)

References 11 publications

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“…Measurements of taurine level in the rat heart were also comparable with previous reports (Jacobsen & Smith, 1968), and Oja & Piha (1966) (4) In adult non-pregnant animals, the concentration of taurine (-24 ,tmol g-1) in the heart was approximately 2-6 times greater than that in the other tissues. (5) Phosphoethanolamine concentrations in adult tissue were similar (1-4-171rnmol g-1) in uterine, intestinal and cerebral tissues but were very low in striated muscle.…”

Section: Discussionsupporting

confidence: 88%

Developmental and gestational changes of phosphoethanolamine and taurine in rat brain, striated and smooth muscle

Turner¹,

Phoenix²,

Wray³

1994

Experimental Physiology

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SUM NI AR YConcentrations of taurine and phosphoethanolamine in rat smooth (intestinaLl aLnd uterine), skeletal and cardiac muscle, and brain have been determined, using high-performiiance liquid chromatography (HPLC), to examine possible interrelationships in their tissue content. Concentrations were determined in fetal and neonatal samples, as well as in aLdult tissue, to investigate whether phosphoethanolanmine and taurine levels are influenced by developmental st(ate. The effect of gestational state was also studied. A marked decrease in cerebral phosphoethanolamine concentration during development was found together with a concomitant decrease in striated muscle but not in the two smooth muscles studied. A rise in uterine phosphoethanolamine during the early postpartum period confirmed previous NMR dalta. This occurred only in the uterus, suggesting it is specific to the process of involution within the myometrium. Tauline concentrations showed no consistent pattern of change with postnatal development. In adult animals, the highest levels of ta-urine were found in cardiac muscle. Pregnancy wa1s Cassocialted with al fall in taLurine concentration in all tissues, suggesting an influence of steroid hormones. As taLurine is cotransported with Na-in many systems it may be related to the increased water retention seen in pregnancy. It is concluded that mnarked changes in phosphoetlhanolamine and taurine levels occur during development and gestation, but that the changes are not interdependent. i.e. the changes are tissUe specific.

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Section: Discussionsupporting

confidence: 88%

Developmental and gestational changes of phosphoethanolamine and taurine in rat brain, striated and smooth muscle

Turner¹,

Phoenix²,

Wray³

1994

Experimental Physiology

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“…We confirmed herein that the GABA levels are high in the rat spinal cord at very early stages of postnatal development as has already been reported (16)(17)(18)(19). The en dogeneous GABA content in the rat brain reportedly increases after birth; and at about three weeks, the level is twofold higher than that at birth (18).…”

Section: Discussionsupporting

confidence: 91%

Postnatal development of the GABA system in the rat spinal cord.

1982

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Abstract-To assess the postnatal development of the GABA system in the rat spinal cord, GABA levels and GAD activity, as well as specific [3H] muscimol binding, were determined in the dorsal and ventral areas. GABA levels and GAD activities did not vary in parallel from 1 to 8 postnatal days since the former decreased and the latter increased.After 8 days, however, increases in GABA levels and GAD activities were observed in tissues from the dorsal area and decreases were observed in tissues from the ventral area. Specific [3H]muscimol binding was unexpectedly high in both areas at 1 and 8 days but decreased linearly up to 22 days. Our findings show that there are distinct differences in the development of the GABA system in the rat spinal cord and brain.

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“…Glutamic acid and glutamine are critical amino acids in brain metabolism and are present in very high concentration in newborn brain [1,2,4,19,23]. This work deals with the placental mechanisms which might be responsible for the high levels of glutamic acid and glutamine.…”

Section: Introductionmentioning

confidence: 99%