Changes in the concentration of urolitiasis markers depending on stone-forming activity in patients with recurrent urolithiasis

Камалов, А А; Okhobotov, D A; Nizov, A N

doi:10.18565/urology.2018.1.15-19

Cited by 2 publications

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“…Significant morbidity and prevalence of genitourinary diseases require improved monitoring and assessment of epidemiological processes, prevention, timely and complete detection of urological pathology, and high-quality treatment [ 11 – 16 ]. This raises relevant tasks to optimize the organization of medical care for urological pathology in the context of healthcare reform [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Optimization of urolithiasis treatment and diagnosis in the Turkestan region

Fathi¹

2022

JMedLife

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The article aims to identify the main problems in treating urological pathologies by analyzing scientific literature from this field and developing recommendations. The quantitative excretion of uric acid, urine volume, and pH are essential in the formation of uric acid stones. The most important risk factor for uric acid nephrolithiasis is the acidic reaction of urine, which is a prerequisite for the formation of urinary stones. When urine is alkalized, the pH should be 6–6.5. Drugs alkalize urine, and one should titrate using urine pH indicator paper until the level is stable. This study found that the spread of genitourinary diseases is increasing. This situation can be improved by monitoring and assessing epidemiological processes, preventing urological pathology, and optimizing medical care organization in the context of health care reform.

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Section: Introductionmentioning

confidence: 99%

Optimization of urolithiasis treatment and diagnosis in the Turkestan region

Fathi¹

2022

JMedLife

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The role of calcium metabolism disorders in the formation of different density calculi with calcium oxalate nephrolithiasis

Budanov

Медведев

Курзанов

et al. 2021

Innovacionnaâ medicina Kubani

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Objective To investigate the relationship between calcium metabolism disorders, stone formation inhibitor levels and stone density in primary and recurrent calcium-oxalate nephrolithiasis.Material and Methods Sixty nine patients with urolithiasis were examined, their average age was 41,4 ± 9,5 years. Two main groups were distinguished: Group 1 – primary calcium-oxalate nephrolithiasis (PN), Group 2 – recurrent calcium-oxalate nephrolithiasis (RN). Then each group was divided into two subgroups – A and B according to stone density: 500–1000 HU and from 1000–1500 HU, respectively. Stone density was determined by computed tomography (CT). PTH (parathormone), PTHrP (parathyroid hormone related protein), vitamin D, total blood calcium (Ca), ionized blood Ca, total blood protein, Ca and urine pH were also examined. After the examination, patients underwent surgical removal of the stones.Results It was found that 41.9% of group 1 and 46.9% of group 2 patients had grade I obesity. Average creatinine level in group 2 was 9.7% higher than in group 1 (p < 0.05). Urea level in both groups was not statistically significantly different. Glomerular filtration rate (GFR) was comparable. Groups 2A and 2B had higher PTHrP values (77.61 and 76.98 pg/mL, respectively) combined with relatively high PTH levels (2A – 4.4 pg/mL and 2B – 5.1 pg/mL), relatively low osteopontin concentration (2A – 0.044 pg/ mL, 2B – 1.106 pg/mL), compared to those in group 1 (p < 0.05). Pairwise unidirectional differences between groups 1A and 2A, 1B and 2B were found to correlate positively with density values: for osteopontin: r = 0.992 (p < 0.05); for vitamin D: r = 0.831 (p < 0.05); for blood Ca2+ ions: r = 0.836 (p < 0.05); for urine pH: r = 0.863 (p < 0.05). There was a negative correlation with the daily concentration of urinary calcium ions with the density of concrements: r = -0.663; p < 0.05. The concentration of osteopontin was significantly higher in Group 1B and 2B patients, and it was significantly lower in patients with stones of < 1000 HU density. Higher values of osteopontin concentration were noted in groups 1B and 2B in relation to groups 1A (p < 0.05) and 2A (p < 0.05). The increase of blood Ca2+ ions in patients in groups 1B and 2B in relation to groups 1A (p < 0.05) and 2A (p < 0.05) was also accompanied by higher values of vitamin D.Conclusion Patients with denser stones showed high values of osteopontin and PTHrP in serum and low values of urinary calcium ions, which may lead to the formation of concrements on the matrix with an organic base. Determination of calcium metabolism makes it possible to predict recurrence of KSD in primary calcium oxalate nephrolithiasis and assess the severity of mineral metabolism disorders in recurrent calcium oxalate nephrolithiasis.

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Changes in the concentration of urolitiasis markers depending on stone-forming activity in patients with recurrent urolithiasis

Cited by 2 publications

References 0 publications

Optimization of urolithiasis treatment and diagnosis in the Turkestan region

Optimization of urolithiasis treatment and diagnosis in the Turkestan region

The role of calcium metabolism disorders in the formation of different density calculi with calcium oxalate nephrolithiasis

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