Changes in the concentrations of amino acids in the cerebrospinal fluid that correlate with pain in patients with fibromyalgia: implications for nitric oxide pathways

Larson, Alice A.; Giovengo, Susan L.; Russell, I. Jon; Michalek, Joel E.

doi:10.1016/s0304-3959(00)00284-0

Cited by 145 publications

(83 citation statements)

References 67 publications

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“…This concurs with the results from Perez-Neri et al [47] where no difference in the CSF arginine levels were observed between healthy human control and patients with infection and inflammatory processes in the CNS, even though both of these conditions are known to be associated with increased NO production. A study applying this very same method for NO analysis in CSF on patients with fibromyalgia has also shown an increase in citrulline level with increasing pain [48].…”

Section: Inhibitory Amino Acidsmentioning

confidence: 88%

Changes in Amino Acids and Nitric Oxide Concentration in Cerebrospinal Fluid During Labor Pain

et al. 2006

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This study analyzes the relationship between amino acids and pain perception during active labor. Cerebrospinal fluid (CSF) levels of the excitatory amino acids (EAAs)-glutamate, aspartate and their amide forms, inhibitory amino acids (IAAs)-glycine, gamma-amino butyric acid (GABA) and taurine and nitric oxide (NO) related compounds-arginine and citrulline (by-product of NO synthesis) were compared between pregnant women at term pregnancy with labor pain (n = 38) and without labor pain (Caesarian section; n = 30). The levels of aspartate, glycine, GABA and citrulline were significantly higher; whilst taurine was significantly lower in the labor pain group. These findings suggest that aspartate and NO are associated with labor pain. An inhibitory role for the IAA taurine and a pronociceptive role for glycine in labor pain are proposed.

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Section: Inhibitory Amino Acidsmentioning

confidence: 88%

Changes in Amino Acids and Nitric Oxide Concentration in Cerebrospinal Fluid During Labor Pain

et al. 2006

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“…Of note, elevated levels of substance P, CGRP, and excitatory amino acids have been found in the cerebrospinal fluid of people with fibromyalgia 187,188 and CRPS.…”

Section: F Widespread Painmentioning

confidence: 99%

Chronic Pain: We Should Not Underestimate the Contribution of Neural Plasticity

Lewis

Rice

2014

Crit Rev Phys Rehabil Med

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Disability associated with chronic pain is a prevalent worldwide problem. Much of our understanding of how and why chronic pain develops has been provided through developments in neural imaging and assessment techniques. Such investigations have highlighted the substantial amount of neural plasticity, or neural reorganisation, that is possible within the nociceptive system. While this plasticity is often physiologically beneficial and usually reverses over time, persistent plasticity can occur following long term activation or damage to the nociceptive system. These adaptations are associated with the development and maintenance of chronic pain conditions. This review provides an outline of the nociceptive system and describes the evidence for plasticity of the system at peripheral, spinal, and supraspinal levels. A number of clinical symptoms associated with chronic pain are described along with the possible neural mechanisms that may contribute to the presentation. Finally, chronic pain management approaches that promote reorganisation of the nociceptive system are discussed. These include sensory training, noninvasive brain stimulation, and mechanisms-based treatment.

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“…Later Omoigui [15] proposed the unifying theory of pain for which the source of all pain is inflammation and inflammatory response. The activation of pain receptors, transmission and modulation of pain signals, neuroplasticity and central sensitivity are all "one continuum" of inflammation and inflammatory response, he also suggested that the pain suffered by women with fibromyalgia it was as a result of neurogenic inflammation present in this disease [16].…”

Section: Inflammation and Fibromyalgiamentioning

confidence: 99%

Altered Inflammatory Mediators in Fibromyalgia

Garcı́a¹,

Carvajal-Gil²,

Herrero-Olea³

et al. 2017

Rheumatology

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Fibromyalgia (FM) is a syndrome characterized by widespread chronic pain, tenderness, stiffness, fatigue, and sleep and mood disturbances. Current evidences suggest that inflammatory mediators may have an important role in the pathogenesis of fibromyalgia. Every day new evidences emerging of the role of the immune system and the inflammatory process in the pathophysiology of this disease. Thus, the aim of this work has been review that altered inductors, inflammatory mediators and effectors have been reported in fibromyalgia, and its relationship to disease's symptoms. If in fibromyalgia underlies widespread disruption of most characteristic components on the inflammatorý s process (endogenous inductors, mediators and effectors) is logical to think that fibromyalgia is producing a sustained inflammatory response in time, unregulated, responsible for the disease´s symptoms. Keywords:Fibromyalgia; Inflammation; HMGB1; Age; Inflammasome; Cytokines; Chemokines; Pentraxins; Lipid mediators; Monocytes; Neutrophils FibromyalgiaFibromyalgia (FM) is a chronic disease characterized by a widespread pain, tenderness, stiffness, fatigue, and sleep and mood disturbances. The prevalence of FM in the world ranges between 0.7% and 3.2%. It is more prevalent on women than men with a ratio women/men 20:1 (4.2% prevalence on women compared with 0.2% on men) [1] and it can develop at any age [2].The exact cause of fibromyalgia is unknown, but it has been proposed that the FM is a stress-related disorder that may involve a dysfunction of the hypothalamic-pituitary-adrenal axis (HPA) [3,4]. Thus, adverse life events, such as emotional, physical and sexual abuse on children and adults have been suggested to contribute to the development of FM [5][6][7].Risk factors FM have been the subject of much debate in recent research. There is no doubt that the experience of an abusive relationship, maintained over time, is a stressful situation that could be related to the presence of FM [8,9].Like all physiological systems, the immune system is under the control of the neuro-endocrine system and interacts and works in concert with other regulatory body systems, thus immune cells respond to neuroendocrine signals through specific receptors for hormones, neurotransmitters and neuropeptides. Therefore, dysregulation of the hypothalamic-pituitary-adrenal axis by chronic stress situations necessarily lead to a dysregulation of the immune function. Thus, inflammation is a characteristic process of the immune system, considered a defense response that is induced by infection or trauma. However, inflammation may also be induced by stress and tissue dysfunction in the absence of infection, there is a close relationship between body homeostasis, stress response and inflammation, since inflammation has both a component response to stress as a component defense response. Inflammation and FibromyalgiaIn 2001, Wallace et al. [10] were the first to suggest that inflammatory mediators, such as cytokines, could play a role in fibromyalgia. Prior results...

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Changes in the concentrations of amino acids in the cerebrospinal fluid that correlate with pain in patients with fibromyalgia: implications for nitric oxide pathways

Cited by 145 publications

References 67 publications

Changes in Amino Acids and Nitric Oxide Concentration in Cerebrospinal Fluid During Labor Pain

Changes in Amino Acids and Nitric Oxide Concentration in Cerebrospinal Fluid During Labor Pain

Chronic Pain: We Should Not Underestimate the Contribution of Neural Plasticity

Altered Inflammatory Mediators in Fibromyalgia

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