Changes in the contents of main secondary metabolites in two Turkish<i>Hypericum</i>species during plant development

Çırak, Cüneyt; Radušienė, Jolita; Camas, Necdet; Çalışkan, Ömer; Odabas, Mehmet Serhat

doi:10.3109/13880209.2012.733012

Cited by 28 publications

(14 citation statements)

References 28 publications

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“…; Cirak et al . ). According to the literature, hypericin and hyperforin have a potent cytotoxic effect through inducing apoptosis in cancer cells (Sačková et al .…”

Section: Resultsmentioning

confidence: 97%

“…These cytotoxic effects of plants may be due to composition of plants themselves. It is known that H. adenotrichum and H. olympicum contains compounds such as hypericin, pseudohypericin, hyperforin (Cirak et al 2009;Cirak et al 2013). According to the literature, hypericin and hyperforin have a potent cytotoxic effect through inducing apoptosis in cancer cells (Sačkov a et al 2011;Billard et al 2013).…”

Section: Apoptosis-inducing Effects Of Hae and Hoementioning

confidence: 99%

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Antigrowth and Apoptosis Inducing Effects of Hypericum Olympicum L . and Hypericum Adenotrichum Spach. on Lung Cancer Cells In Vitro : Involvement of DNA Damage

Aztopal

Erkısa

Çelikler

et al. 2016

Journal of Food Biochemistry

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Hypericum species are used in different folk medicines and screened for their biological activity including cancer. We, therefore, evaluated the possible cytotoxic/ apoptotic and genotoxic activities of Hypericum adenotrichum Spach. and Hypericum olympicum L. Antigrowth effect was screened in human lung cancer cell lines (A549 and PC3) by the ATP viability assay, while genotoxic activity was performed using the Comet assay. Histological and biochemical methods were utilized to elucidate the cell death mode. The results indicate that the crude methanol extracts of H. olympicum L. and H. adenotrichum have both antigrowth/ cytotoxic and genotoxic activities on these cells in a dose dependent manner. These extracts clearly induced apoptosis in PC3 lung cancer cell lines. In this study, we report for the first time that the H. olympicum and H. adenotrichum exhibits potential cytotoxic and genotoxic activities in lung cancer cells as well as the apoptosis-inducing roles through DNA damage in PC3 cells. PRACTICAL APPLICATIONSMedicinal plants are used in traditional medicine worldwide and several have been screened for their anticancer properties, we evaluated the possible cytotoxic and genotoxic activities of the Hypericum adenotrichum and Hypericum olympicum, which are still used in Turkish folk medicine. H. adenotrichum Spach., an endemic species in Turkey, and H. olympicum L., which are known as "kantaron" and used traditionally for their wound healing and antiseptic properties. It was found that Hypericum species showed a significant growth-inhibiting effect on human lung cancer cells and induced apoptosis-like cell death by DNA damage in PC3 lung cancer cells. These species may have a potential as anticancer agents and inspire to new improvements for medicinal chemistry.

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“…; Cirak et al . ). According to the literature, hypericin and hyperforin have a potent cytotoxic effect through inducing apoptosis in cancer cells (Sačková et al .…”

Section: Resultsmentioning

confidence: 97%

Section: Apoptosis-inducing Effects Of Hae and Hoementioning

confidence: 99%

Antigrowth and Apoptosis Inducing Effects of Hypericum Olympicum L . and Hypericum Adenotrichum Spach. on Lung Cancer Cells In Vitro : Involvement of DNA Damage

Aztopal

Erkısa

Çelikler

et al. 2016

Journal of Food Biochemistry

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“…It was found out in strawberries [Bagdonaite et al 2013], blueberries [Hicks et al 2012], whitethorn [Belkhir et al 2013] and rowan [Gaivelyte et al 2013]. Among herbs, it is abundant above all in St John's wort [Cirak et al 2013]. According to Web of Science (WOS), the occurrence of this compound has not been studied yet.…”

Section: Resultsmentioning

confidence: 99%

Assessment of Antioxidants by HPLC-MS in Grapevine Seeds

Sochorová

Klejdus

Baroň

et al. 2019

asphc

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It is well known, that grapevine seeds are rich in significant antioxidants. However, the issue of dealing with the analysis and comparison of antioxidant components in the seeds of Vitis vinifera L. in individual cultivars has not yet been sufficiently studied. The experiment was performed with extracts of three varieties (Blaufränkish, Italian Riesling and Cabernet Moravia) and three interspecific cultivars (Nativa, Marlen and Kofranka). Contents of nine major flavonoids (apigenin, astragalin, hyperoside, isorhamnetin, kaempferol, myricetin, quercetin, quercitrin and rutin) and two procyanidins (procyanidin A 2 and procyanidin B 1 ) were assessed by the HPLC/MS method. The highest contents of antioxidants were found out in interspecific cultivars Marlen and Nativa while the lowest one was assessed in the cultivar Cabernet Moravia. The most represented flavonoid was hyperoside (cultivar Marlen -15.66 mg•l -1 ), least represented was kaempferol (cultivar Cabernet Moravia -1.81 µg•l -1 ).

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“…The cytotoxic effects of HAE and HOE may be due to composition of plants. It is known that Hypericum adenotrichum and Hypericum olympicum contains compounds such as hypericin, pseudohypericin, hyperforin [35,36]. Hypericin and hyperforin have a potent cytotoxic effect through inducing apoptosis in cancer cells [37,38].…”

Section: Hypericum Adenotrichum Hypericum Olympicummentioning

confidence: 99%

Nonapoptotic cell death induced by Hypericum species on cancer cells

Arı¹,

Aztopal²,

Erkısa³

et al. 2017

The European Research Journal

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Objectives. There are approximately 400 Hypericum species that grow naturally in different geographic origins of the world. Those species have been used in different folk medicines and screened for their biological activity including cancer. Our country is an important place for Hypericum species which are known as "kantaron, binbirdelik otu, kan otu, kılıç otu, yaraotu, kuzukıran". We therefore evaluated the possible cytotoxic/apoptotic activities, total phenolic content and antioxidant capacity of the crude methanol extracts Hypericum adenotrichum Spach. and Hypericum olympicum L. which are still used in Turkish folk medicine. Methods. The total phenolic content and antioxidant capacity were determined by Folin-Ciocalteu and ABTS methods. Anti-growth effects were screened in human hepatoma (Hep3B) and rat glioma (C6) cell lines by the MTT and ATP viability assays. The cell death mode (apoptosis/necrosis) was investigated by fluorescence imaging and the level of caspase-cleaved cytokeratin 18 (M30), active caspase-3 and cleaved PARP (poly (ADP-ribose) polymerase). Results. The results indicate that the crude methanol extracts of Hypericum olympicum L. and Hypericum adenotrichum have both anti-growth/cytotoxic activities on these cells in a dose dependent manner. Conclusion. These extracts clearly induced non-apoptotic cell death in human hepatoma (Hep3B) and rat glioma (C6) cell lines.

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Changes in the contents of main secondary metabolites in two TurkishHypericumspecies during plant development

Cited by 28 publications

References 28 publications

Antigrowth and Apoptosis Inducing Effects of Hypericum Olympicum L . and Hypericum Adenotrichum Spach. on Lung Cancer Cells In Vitro : Involvement of DNA Damage

Antigrowth and Apoptosis Inducing Effects of Hypericum Olympicum L . and Hypericum Adenotrichum Spach. on Lung Cancer Cells In Vitro : Involvement of DNA Damage

Assessment of Antioxidants by HPLC-MS in Grapevine Seeds

Nonapoptotic cell death induced by Hypericum species on cancer cells

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