Changes in the cupula after disruption of the membranous labyrinth

Kondo, Takahito; Suzuki, Mamoru; Konomi, Ujimoto; Otsuka, Koji; Inagaki, Taro; Shimizu, Shigetaka; Ogawa, Yasuo

doi:10.3109/00016489.2011.635385

Cited by 10 publications

(3 citation statements)

References 10 publications

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“…It is expected that the movement of the cupula will change as it shrinks. Kondo et al observed similar cupular changes after puncturing the membranous labyrinth 17 . The cupula was also found to change in a high osmolarity environment 18 .…”

Section: Discussionmentioning

confidence: 82%

Relationship between clinical features and therapeutic approach for benign paroxysmal positional vertigo outcomes

et al. 2013

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For patients with posterior canal benign paroxysmal positional vertigo, resolution time was significantly shorter in the Epley manoeuvre group than in the medication group. For the lateral canal canalolithiasis patients, resolution time was significantly shorter in the Lempert manoeuvre group than in the medication group. Resolution time was significantly longer in the lateral canal cupulolithiasis patients than in the other patients. The average age of patients increased with the number of recurrences, as did predominance in females. Average age and rate of sensorineural hearing loss were significantly higher in patients with intractable benign paroxysmal positional vertigo compared with those in the curable benign paroxysmal positional vertigo group.

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Section: Discussionmentioning

confidence: 82%

Relationship between clinical features and therapeutic approach for benign paroxysmal positional vertigo outcomes

et al. 2013

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“…To the best of our knowledge, morphological changes in the cupula have never been reported in studies on the human temporal bone. According to animal models, the cupula shrinks into the inner ear after gentamicin injection and enlarges after disruption of the membranous labyrinth [ 13 , 14 ]. When the cupula becomes enlarged and the mass remains constant, its relative density should decrease.…”

Section: Discussionmentioning

confidence: 99%

Intractable Persistent Direction-Changing Geotropic Nystagmus Improved by Lateral Semicircular Canal Plugging

Seo

Saito

Doi

2015

Case Reports in Otolaryngology

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Antigravitational deviation of the cupula of the lateral semicircular canal, which is also called light cupula, evokes persistent direction-changing geotropic nystagmus with a neutral point. No intractable cases of this condition have been reported. In our case, a 67-year-old man complained of positional vertigo 3 months after developing idiopathic sudden hearing loss in the right ear with vertigo. He showed a persistent direction-changing geotropic nystagmus with a leftward beating nystagmus in the supine position. The nystagmus resolved when his head was turned approximately 30° to the right. He was diagnosed with light cupula of the right lateral semicircular canal and was subsequently treated with an antivertiginous agent. However, his symptoms and positional nystagmus did not improve, so the right lateral semicircular canal was plugged by surgery. One month after surgery, his positional vertigo and nystagmus were completely resolved. We speculated that the cause of the patient's intractable light cupula was an enlarged cupula caused by his idiopathic sudden hearing loss.

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“…potential. Even when the cupula is severely damaged the physiological activity of the sensory epithelia is maintained 114,115 . They assume that when the cupula shrinks, the activity to stimuli is reduced and thereby caloric response.…”

Section: Lateralization Of Affected Side By Ewald's Second Lawmentioning

confidence: 99%

Is the nystagmus pattern in hemi-labyrinthectomized subjects during positional alcohol nystagmus 2 similar to that found in patients with cupulolithiasis in the lateral semicircular canal?

Tomanovic

Bergenius²

2013

Acta Oto-Laryngologica

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When the subjects were examined with their heads turned in the supine or prone positions, the alcohol-induced nystagmus pattern was compatible with that of cupulolithiasis. When the head was pointed straight forward in the prone and supine positions, the nystagmus directions were opposite to those found during PAN 1. Directional preponderance was not seen for the apogeotropic nystagmus for either ampullofugal or ampullopetal deviation of the cupula.

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Changes in the cupula after disruption of the membranous labyrinth

Cited by 10 publications

References 10 publications

Relationship between clinical features and therapeutic approach for benign paroxysmal positional vertigo outcomes

Relationship between clinical features and therapeutic approach for benign paroxysmal positional vertigo outcomes

Intractable Persistent Direction-Changing Geotropic Nystagmus Improved by Lateral Semicircular Canal Plugging

Is the nystagmus pattern in hemi-labyrinthectomized subjects during positional alcohol nystagmus 2 similar to that found in patients with cupulolithiasis in the lateral semicircular canal?

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