Changes in the Deformational Behavior of Human Hip Cartilage With Age

Armstrong, Cecil; Bahrani, A.S.; Gardner, D. L.

doi:10.1115/1.3149576

Cited by 37 publications

(11 citation statements)

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“…Fourth, middle-aged or elderly subjects averaging 60 years old represented the majority of the sample in the present study. Previous studies showed that the articular cartilage of the femoral head showed significant increases in the normal population at 20-30 years of age [35]. Our findings regarding relationships between JSW and patients' profiles or hip structural parameters may not be applicable to younger populations without osteoarthritis.…”

Section: Discussioncontrasting

confidence: 63%

Computational measurement of joint space width and structural parameters in normal hips

Nishii

Shiomi

Sakai

et al. 2012

Arch Orthop Trauma Surg

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Section: Discussioncontrasting

confidence: 63%

Computational measurement of joint space width and structural parameters in normal hips

Nishii

Shiomi

Sakai

et al. 2012

Arch Orthop Trauma Surg

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“…The early constitutive models of articular cartilage were single-phase, that is, only the solid phase of the tissue was considered [23–28]. These models have limited capabilities in describing the time-dependent response of cartilage, which is mainly due to the interstitial fluid flow when the tissue is in compression.…”

Section: Constitutive Modeling Of the Tissuesmentioning

confidence: 99%

“…Articular cartilages were commonly modeled as single-phase, linear elastic, homogenous, and isotropic materials with constant stiffness [80, 81, 84, 113, 141]. Due to the high viscoelastic time constant of cartilage [28] (~1500 s), there is no time for fluid flow at the instant of loading, and thus, the tissue may be considered as a single-phase material with a large equivalent elastic modulus for the short-term response. However, if the loading is not fast or if the time-dependent response of the knee is sought, the single-phase aclssumption is not satisfactory [32, 87].…”

Section: Computational Models Of the Knee Jointmentioning

confidence: 99%

Recent Advances in Computational Mechanics of the Human Knee Joint

Kazemi

Dabiri

2013

Computational and Mathematical Methods in Medicine

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Computational mechanics has been advanced in every area of orthopedic biomechanics. The objective of this paper is to provide a general review of the computational models used in the analysis of the mechanical function of the knee joint in different loading and pathological conditions. Major review articles published in related areas are summarized first. The constitutive models for soft tissues of the knee are briefly discussed to facilitate understanding the joint modeling. A detailed review of the tibiofemoral joint models is presented thereafter. The geometry reconstruction procedures as well as some critical issues in finite element modeling are also discussed. Computational modeling can be a reliable and effective method for the study of mechanical behavior of the knee joint, if the model is constructed correctly. Single-phase material models have been used to predict the instantaneous load response for the healthy knees and repaired joints, such as total and partial meniscectomies, ACL and PCL reconstructions, and joint replacements. Recently, poromechanical models accounting for fluid pressurization in soft tissues have been proposed to study the viscoelastic response of the healthy and impaired knee joints. While the constitutive modeling has been considerably advanced at the tissue level, many challenges still exist in applying a good material model to three-dimensional joint simulations. A complete model validation at the joint level seems impossible presently, because only simple data can be obtained experimentally. Therefore, model validation may be concentrated on the constitutive laws using multiple mechanical tests of the tissues. Extensive model verifications at the joint level are still crucial for the accuracy of the modeling.

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“…Representative stress-strain curves for arbitrary layers 1-5 at -05 s after start of loading.jp o,~~~~p Fig 3. Series ofsix micrographs taken during load sequence at 0 load, 0 stress (1); 6-3 g, 34 glmm2 (2); 16 g, 85 glmm2 (3); 32 g, 170 glmm2 (4); 44 g, 238 glmm2 (5); 50 g, 270 g/mm2(6).…”

mentioning

confidence: 99%

Differential response to compressive loads of zones of canine hyaline articular cartilage: micromechanical, light and electron microscopic studies.

OʼConnor¹,

Orford²,

Gardner³

1988

Annals of the Rheumatic Diseases

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SUMMARY Thin (100 urm) perpendicular slices of canine femoral condylar cartilage were placed horizontally on the stage of a Nachet microscope and viewed by transmitted light in the differential interference contrast mode. Each slice was held on the microscope stage by a loading rig and tested mechanically in compression. Measured loads to a maximum of -2-3 MN/M2 were applied to the end of the slice corresponding to the articular surface. Photographs were taken of the cartilage before and during loading, and the distance by which selected chondrocytes were displaced was used as an index of mechanical strain, i.e., of change in length/original length. Maximum strains were observed in the superficial cartilage zone. Minimum strains were recorded in the mid-zone, at a depth corresponding to -75% of the total cartilage thickness. The relative concentrations of cartilage collagen (COL) and proteoglycan (PG) were assessed by the light and electron microscopic histochemical study of cartilage sections taken from contiguous blocks. Superficial cartilage, which deformed most, had high concentrations of orientated COL fibres, low concentrations of PG. Mid-zone cartilage, which deformed least, had lower concentrations of randomly arrayed COL fibres but relatively high concentrations of PG.Hyaline articular cartilage appears uniform and homogeneous and has unique mechanical properties that include high compression resistance. This property is determined by the retention of water within the domains of PG aggregates arranged within a gel reinforced with COL fibres. The physical properties of cartilage have been examined by many classical mechanical procedures.' Experiments have been made on whole joints,2 3 parts of disarticulated joints,4 and pieces of cartilage.Tests have been made in tension and in compression, but most have not distinguished between the properties of different cartilage zones.The apparent homogeneity of articular cartilage conceals remarkable molecular heterogeneity. It is useful to consider cartilage as a series of different zones, each with a distinct microscopic structure and varied composition. In the most simple analysis, articular cartilage can be said to comprise superficial, mid-, and deep zones.9 In a more sophisticated

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Changes in the Deformational Behavior of Human Hip Cartilage With Age

Cited by 37 publications

References 0 publications

Computational measurement of joint space width and structural parameters in normal hips

Computational measurement of joint space width and structural parameters in normal hips

Recent Advances in Computational Mechanics of the Human Knee Joint

Differential response to compressive loads of zones of canine hyaline articular cartilage: micromechanical, light and electron microscopic studies.

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