Changes in the Epidemiology of Cutaneous Leishmaniasis in Northeastern Iran

Farash, Bibi Razieh Hosseini; Shamsian, Seyed Ali Akbar; Mohajery, Masoud; Fata, Abdolmajid; Sadabadi, Fatemeh; Berenji, Fariba; Mastroeni, Pietro; Poustchi, Elham; Moghaddas, Elham; Sangani, Ghodratollah Salehi; Farnoosh, Gholamreza

doi:10.4274/tpd.galenos.2019.6137

Cited by 10 publications

(5 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results obtained showed that the Leishmania species present in all 100 samples was L. major , which is not surprising. In previous work at these regions, L. major was the dominant causative agent of leishmaniasis ( 20 ).…”

Section: Discussionmentioning

confidence: 99%

Molecular Identification and Phylogenetic Analysis of Leishmania major Isolated from Zoonotic Cutaneous Leishmaniasis Foci in Northeast Iran

Shamsian,

Mirizadeh,

Sangani

et al. 2023

IJPA

View full text Add to dashboard Cite

Background: Epidemiological studies, classification and genetic studies of Leishmania species are effective in treatment, control and prevention in endemic areas. We aimed to investigate the genetic diversity and phylogeny of Leishmania in Zoonotic foci located in northeastern Iran using nagt gene for the first time. Methods: DNA of 100 confirmed positive slides collected from the health centers of Sarkhes, Darghez, Fariman, Esfarayen, and Sabzevar were extracted during 2020-2021. The partial sequence of kDNA was amplified to identify the species. Twenty-five DNA samples were randomly subjected to amplify by nagt gene primes and were sequenced. The sequences were aligned with reference sequences in National Center for Biotechnology Information (NCBI). Then, the genetic similarities of the sequences were checked using Clustalx2.1 software and the phylogenetic tree was drawn by Mega 7 software. Results: All the positive samples were diagnosed as L. major. Approximately, half of the sequences of species were similar to two reference genes JX103550.1:404-712 L. major Esfahan and KX759012.1:568-807 L. Major Ilam (more than 90% similarity). According to the results of the phylogeny tree, the closest genotype to our study samples was JX103550.1:404-712 L. major Esfahan. Conclusion: The most causative agent CL in these areas was L. major. The genetic diversity of L. major was high such as other zoonotic foci in Iran. Due to the high similarity of the strains in the study areas with the strains of Isfahan and Ilam, similar control and prevention methods is suggested in these areas.

show abstract

Section: Discussionmentioning

confidence: 99%

Molecular Identification and Phylogenetic Analysis of Leishmania major Isolated from Zoonotic Cutaneous Leishmaniasis Foci in Northeast Iran

Shamsian,

Mirizadeh,

Sangani

et al. 2023

IJPA

View full text Add to dashboard Cite

show abstract

“…Rodents are the main reservoir hosts, and some of the more endemic species include Rhombomys (R.) opimus, Meriones libycus, Ta t e ra (T. ) indica, and Meriones hurrianae. Phlebotomus papatasi transmits L. major, whereas Phlebotomus sergenti transmits L. tropica [70,[77][78][79]. ACL and ZCL are present, L. tropica and L. major are endemic in Saudi Arabia, and CL is declining with fewer instances being reported [80][81][82][83].…”

Section: New World Cutaneous Leishmaniasismentioning

confidence: 99%

Epidemiology of Leishmaniasis

Kyari

2024

Leishmania Parasites - Epidemiology, Immunopathology and Hosts

View full text Add to dashboard Cite

A zoonotic illness of importance to the public’s health is leishmaniasis. Leishmania donovani, Leishmania tropica, Leishmania major, Leishmania infantum, Leishmania chagasi, Leishmania mexican, and Leishmania braziliensis are the most recognised and widely distributed leishmania parasite species, and they are also the ones that cause the disease. On every continent and in more than 90 countries, the disease is present, however it appears to be absent from Australia. The disease is spread by Phlebotomus sandflies, and people, rodents, and other domestic animals act as reservoirs and unintentional hosts. Cutaneous leishmaniasis, diffuse cutaneous leishmaniasis, mucocutaneous leishmaniasis, and visceral leishmaniasis are the four ways the illness can present. The spread of the disease, as well as its appearance and reemergence, are caused by risk factors include regional warfare and wars, political instability, migration of people, substandard housing, climate, vegetation cover, p7oor socioeconomic standard of life, and lack of access to quality medical care. To eradicate the disease, particularly in poor nations where it is still a threat, there is a need for increased public education, government involvement, proper surveillance, and disease reporting.

show abstract

“…CL is endemic in 87 countries globally, with an estimated 500,000 to 1,000,000 new cases reported each year [36] . The majority of cases occurred in two regions (Eastern Mediterranean Region and America Region), mostly in seven countries: Afghanistan [51,52] , Algeria [53,54] , Brazil [55,56] , Iran [57,58] , Iraq [59,60] , Pakistan [61,62] and Syria [63] . The transmission cycle of the infection involves various species of leishmania, some of which are zoonotic, with reservoir hosts that can vary between domestic and wild mammals.…”

Section: Overview Of Cutaneous Leishmaniasismentioning

confidence: 99%

Cutaneous Leishmaniasis: Physiopathology, Molecular Diagnostic, and Therapeutic Approaches

Balahbib,

Hmamouch,

El Allam

et al. 2023

Prog Micobes Mol Biol

View full text Add to dashboard Cite

This in-depth study explores various aspects of cutaneous leishmaniasis, shedding light on the physiopathology of the infection, advances in molecular diagnostic techniques, and therapeutic approaches currently in development. Our investigation seamlessly integrates fundamental and clinical research data to provide a comprehensive perspective on this debilitating disease. Cutaneous leishmaniasis, primarily manifested through skin lesions, poses a significant diagnostic challenge. We delve into molecular diagnostic methods, especially PCR, emphasizing their crucial role in accurately detecting the infection. Simultaneously, we examine the implications of the physiopathology of cutaneous leishmaniasis, unveiling the complex mechanisms underlying this disease. In terms of treatment, we scrutinize current therapeutic approaches, highlighting limitations associated with using antimonials. Our study also explores alternative solutions, investigating the potential benefits of flavonoids and other natural compounds, thus offering innovative therapeutic perspectives. In conclusion, this research aims to enhance the understanding of cutaneous leishmaniasis from a diagnostic and therapeutic standpoint. This review is an essential resource for healthcare professionals and researchers, laying the groundwork for an integrated and holistic approach to better comprehend and treat this complex disease.

show abstract

Changes in the Epidemiology of Cutaneous Leishmaniasis in Northeastern Iran

Cited by 10 publications

References 22 publications

Molecular Identification and Phylogenetic Analysis of Leishmania major Isolated from Zoonotic Cutaneous Leishmaniasis Foci in Northeast Iran

Molecular Identification and Phylogenetic Analysis of Leishmania major Isolated from Zoonotic Cutaneous Leishmaniasis Foci in Northeast Iran

Epidemiology of Leishmaniasis

Cutaneous Leishmaniasis: Physiopathology, Molecular Diagnostic, and Therapeutic Approaches

Contact Info

Product

Resources

About