Changes in the expression of the potassium channels TASK1, TASK3 and TRESK in a rat model of oral squamous cell carcinoma and their relation to malignancy

Zavala, Walther David; Fóscolo, M.R.; Cavicchia, Juan C.; Acosta, Cristian

doi:10.1016/j.archoralbio.2019.02.007

Cited by 7 publications

(6 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…KCNK2 was detected as a prognostic factor in breast cancer, which was similar with previous study ( Li et al, 2019 ). The KCNK9 gene, commonly referred to as TASK-3, was associated with cancer due to its overexpression in human tumors and its ability to promote tumor survival and growth ( Zavala et al, 2019 ). Base on the previous research, KCNK9 was overexpressed in rectal cancer, melanoma, and adrenal cortical adenocarcinoma ( Sun et al, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

“…TASK-1 Regulates Apoptosis and Proliferation in a Subset of Non-Small Cell Lung Cancers ( Leithner et al, 2016 ). TASK3 was significantly up-regulated whereas TASK1 and TRESK were both significantly down-regulated in advanced, poorly differentiated oral squamous cell carcinoma ( Zavala et al, 2019 ). Overexpression rather than mutation of KCNK9 may contribute to the development of colorectal cancer ( Kim et al, 2004 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Integrative Analysis of KCNK Genes and Establishment of a Specific Prognostic Signature for Breast Cancer

Zou

Xie

Tian

et al. 2022

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Two-pore domains potassium channel subunits, encoded by KCNK genes, play vital roles in breast cancer progression. However, the characteristics of most KCNK genes in breast cancer has yet to be clarified. In this study, we comprehensively analyzed the expression, alteration, prognosis, and biological functions of various KCNKs in breast cancer. The expression of KCNK1/4/6/9/10/13 were significantly upregulated, while KCNK2/3/5/7/17 were downregulated in breast cancer tissues compared to normal mammary tissues. Increased expression of KCNK1/3/4/9 was correlated with poor overall survival, while high expression of KCNK2/7/17 predicted better overall survival in breast cancer. Eight KCNK genes were altered in breast cancer patients with a genomic mutation rate ranged from 1.9% to 21%. KCNK1 and KCNK9 were the two most common mutations in breast cancer, occurred in 21% and 18% patients, respectively. Alteration of KCNK genes was associated with the worse clinical characteristics and higher TMB, MSI, and hypoxia score. Using machine learning method, a specific prognostic signature with seven KCNK genes was established, which manifested accuracy in predicting the prognosis of breast cancer in both training and validation cohorts. A nomogram with great predictive performance was afterwards constructed through incorporating KCNK-based risk score with clinical features. Furthermore, KCNKs were correlated with the activation of several tumor microenvironment cells, including T cells, mast cells, macrophages, and platelets. Presentation of antigen, stimulation of G protein signaling and toll-like receptor cascaded were regulated by KCNKs family. Taken together, KCNKs may regulate breast cancer progression via modulating immune response which can serve as ideal prognostic biomarkers for breast cancer patients. Our study provides novel insight for future studies evaluating their usefulness as therapeutic targets.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Integrative Analysis of KCNK Genes and Establishment of a Specific Prognostic Signature for Breast Cancer

Zou

Xie

Tian

et al. 2022

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

show abstract

“…In gastric cancer(GC) cell lines, TASK-3 is a crucial protein involved in migration and cell survival, and low TASK-3 expression decreases cell proliferation and migration ( 52 ). In addition, TASK-3 was significantly upregulated in oral squamous cell carcinoma tissues in a rat model, and both TASK-1 and TRESK were downregulated in advanced poorly differentiated oral squamous cell carcinoma ( 53 ). KCNK15 is highly expressed in PC cells, and researchers have found that KCNK15-AS1 hinders the migration and proliferation of PC cells by regulating KCNK15 and the tumor suppressor gene PTEN ( 54 ).…”

Section: Relationship Between Potassium Channel and Tumormentioning

confidence: 99%

Potassium channels: Novel targets for tumor diagnosis and chemoresistance

Tian

Zhao

et al. 2023

Front. Oncol.

View full text Add to dashboard Cite

In recent years, the role of potassium channels in tumors has been intensively studied. Potassium channel proteins are widely involved in various physiological and pathological processes of cells. The expression and dysfunction of potassium channels are closely related to tumor progression. Potassium channel blockers or activators present antitumor effects by directly inhibiting tumor growth or enhancing the potency of classical antitumor agents in combination therapy. This article reviews the mechanisms by which potassium channels contribute to tumor development in various tumors in recent years, introduces the potential of potassium channels as diagnostic targets and therapeutic means for tumors, and provides further ideas for the proper individualized treatment of tumors.

show abstract

“…In cancer cells, there are significant alterations in the expression of K + -channels, which is manifested not only by the increase in their total expression, but also in the relative proportion of their different subtypes (Jiang et al, 2017;Zavala et al, 2019). The most prominent ion channel subfamilies present in primary tumors and metastases include Kv, Ether-àgo-go (EAG), and K Ca (Tian et al, 2014;Kuang et al, 2015).…”

Section: K + -Channels In Cancermentioning

confidence: 99%

Voltage-Gated K+/Na+ Channels and Scorpion Venom Toxins in Cancer

Díaz-García

Varela

2020

Front. Pharmacol.

View full text Add to dashboard Cite

Ion channels have recently been recognized as novel therapeutic targets in cancer research since they are overexpressed in different histological tissues, and their activity is linked to proliferation, tumor progression, angiogenesis, metastasis, and apoptosis. Voltage gated-potassium channels (VGKC) are involved in cell proliferation, cancer progression, cell cycle transition, and apoptosis. Moreover, voltage-dependent sodium channels (VGSC) contribute to decreases in extracellular pH, which, in turn, promotes cancer cell migration and invasion. Furthermore, VGSC and VGKC modulate voltagesensitive Ca 2+ channel activity by controlling the membrane potential and regulating Ca 2+ influx, which functions as a second messenger in processes related to proliferation, invasion, migration, and metastasis. The subgroup of these types of channels that have shown a high oncogenic potential have become known as "oncochannels", and the evidence has highlighted them as key potential therapeutic targets. Scorpion venoms contain a high proportion of peptide toxins that act by modulating voltage-gated Na + /K + channel activity. Increasing scientific data have pointed out that scorpion venoms and their toxins can affect the activity of oncochannels, thus showing their potential for anticancer therapy. In this review, we provide an update of the most relevant voltage-gated Na + \K + ion channels as cellular targets and discuss the possibility of using scorpion venom and toxins for anticancer therapy.

show abstract

Changes in the expression of the potassium channels TASK1, TASK3 and TRESK in a rat model of oral squamous cell carcinoma and their relation to malignancy

Cited by 7 publications

References 57 publications

Integrative Analysis of KCNK Genes and Establishment of a Specific Prognostic Signature for Breast Cancer

Integrative Analysis of KCNK Genes and Establishment of a Specific Prognostic Signature for Breast Cancer

Potassium channels: Novel targets for tumor diagnosis and chemoresistance

Voltage-Gated K+/Na+ Channels and Scorpion Venom Toxins in Cancer

Contact Info

Product

Resources

About