Changes in the Gastric Mucosa With Aging

Sonnenberg, Amnon; Genta, Robert M.

doi:10.1016/j.cgh.2015.02.020

Cited by 60 publications

(45 citation statements)

References 15 publications

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“…Sonnenberg and Genta conducted an analysis of 895 323 patients who underwent upper endoscopy in the United States and were recorded in a large national pathology database . Overall lesions related to H. pylori infection were present in 22% of the biopsies, these being the most common gastric abnormalities observed.…”

Section: Natural Course Of H Pyloriinfectionmentioning

confidence: 99%

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Epidemiology of Helicobacter pylori infection

2016

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This review of recent publications related to the epidemiology of Helicobacter pylori highlights the origin of the infection, its changing prevalence, transmission, and outcome. A number of studies have addressed the ancestor roots of the bacteria, and the first genomewide analysis of bacterial strains suggests that its coexistence with humans is more ancient than previously thought. As opposed to the generally declining prevalence of H. pylori (including China and Japan), in Sweden, the prevalence of atrophic gastritis in the young population has risen. The prevalence of the infection remains high in the indigenous populations of the Arctic regions, and reinfection rates are high. A high prevalence is permanently found in the Siberian regions of Russia as well. Several studies, some of which used multiplex serology, addressed prevalence of and risks associated with various H. pylori serotypes, thereby enabling more precise risk assessment. Transmission of H. pylori was discussed, specifically fecal-oral transmission and the use of well-water and other unpurified water. Finally, the long-term course of H. pylori infection was considered, with an estimated 89% of noncardia gastric cancer cases being attributable to the infection.

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Section: Natural Course Of H Pyloriinfectionmentioning

confidence: 99%

“…Overall lesions related to H. pylori infection were present in 22% of the biopsies, these being the most common gastric abnormalities observed. Reactive gastropathy, detected in 18% of the biopsies, increased with age and was the second most common gastric pathology observed …”

Section: Natural Course Of H Pyloriinfectionmentioning

confidence: 99%

Epidemiology of Helicobacter pylori infection

2016

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“…A majority of chronic non‐atrophic gastritis is stable, especially in those without persistent H. pylori infection. Some patients have histopathological changes such as atrophy due to aging . The updated view is that regardless of age, persistent H. pylori infection may lead to chronic atrophic gastritis.…”

Section: Outcomes Of Chronic Gastritis and The Prevention Of Gastric mentioning

confidence: 99%

“…Some patients have histopathological changes such as atrophy due to aging. 134,135 The updated view is that regardless of age, persistent H. pylori infection may lead to chronic atrophic gastritis. The gastric mucosa of people at the same age can present with varying degrees of aging, that is, different "stomach ages"; the latter can be measured and calculated based on the telomere length of gastric mucosal cells.…”

Section: Statement 43mentioning

confidence: 99%

Chinese consensus on chronic gastritis (2017, Shanghai)

Fang¹,

Du²,

Liu³

et al. 2018

J of Digest Diseases

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“…Prevalence of normal gastric mucosa was said to decrease in line with the addition of age, either with or without the presence of H. pylori infection. 20 In older patients, there will be a decreased capacity of defensive factors in gastric mucosa to maintain gastric mucosal integrity. It may relate to the decrease in the production of mucous and bicarbonate.…”

Section: Discussionmentioning

confidence: 99%