“…The present study is not concerned particularly with the first, an outstanding example of which is diminution or loss of the "intrinsic factor" from the stomach, which is responsible for Addisonian pernicious anemia. The absorptive mechanism may be at fault in a variety of ways, for example, when diarrhea is present, or when there are pathological changes, such as ulcerations of the bowel, infections, stricture or tumor, which may, by mechanisms not well understood, affect motility or produce mucosal changes (1,2,3).…”